Human chorionic gonadotropin and unconjugated oestriol measurements in insulin-dependent diabetic pregnant women being screened for fetal down syndrome

This prospective study investigates the relationship between insulin-dependent diabetes and maternal serum levels of alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG). It also examines the potential impact on screening for Down syndrome. The population-based cohort included 20 321 pregnant women in Maine who underwent routine serum screening for Down syndrome in the second trimester. The cohort included 52 women with insulin-dependent diabetes. Maternal serum AFP levels are now routinely adjusted for insulin-dependent diabetes. These adjustments, therefore, were made routinely in the diabetic women, but no equivalent adjustments were made for uE3 and hCG values. The initial false-positive rate (using all three markers) among the women with diabetes was not significantly different from that in the non-diabetic population (7·7 and 5·4 per cent, respectively). Prior to adjustment for insulin-dependent diabetes, the median AFP level in the 52 women was 0·73 multiples of the median (MOM); the median levels of uE3 and hCG were 0·93 and 0·98 MOM, respectively. When the uE3 and hCG levels were adjusted, the initial false-positive rate was unchanged. Median serum levels of uE3 were significantly higher in the 33 women whose onset of diabetes was prior to 19 years of age (0·99 MOM) than in the 19 women whose onset of diabetes was at age 19 or older (0·84 MOM). This is the first population-based study to investigate the relationship between diabetes and serum levels of AFP, uE3, and hCG, and confirms earlier observations from a case—control study that found only slightly lower uE3 and hCG levels.     

Risk-based prenatal screening for trisomy 18 using alpha-fetoprotein,unconjugated oestriol and human chorionic gonadotropin

Nine centres collaborated to examine the feasibility of a screening method for trisomy 18 that was based on assigning individual risk, using a combination of maternal age and measurements of alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG). Second-trimester measurements of these analytes were obtained from 94 trisomy 18 pregnancies. In the 89 pregnancies without an associated open defect, the median levels for AFP, uE3, and hCG were 0.65, 0.43 and 0.36 multiples of the unaffected population median, respectively. The strongest individual predictor of risk for trisomy 18 was uE3, followed by hCG, AFP, and maternal age, in that order. Using a method of individual risk estimation that is based on the three markers and maternal age, 60 per cent of pregnancies associated with trisomy 18 would be detected at a risk cut-off level of 1:100, with a false-positive rate of about 0.2 per cent. One in nine pregnancies identified as being at increased risk for trisomy 18 would be expected to have an affected pregnancy. This risk-based screening method is more efficient than an existing method that is based on fixed analyte cut-off levels. Even though the birth prevalence of trisomy 18 is low, prenatal screening can be justified when performed in conjunction with Down syndrome screening and when a high proportion of women offered amniocentesis have an affected fetus.     

Effects of channel incision on base flow stream habitats and fishes

Channel incision is a widespread phenomenon that results in stream and riparian habitat degradation. Fishes and physical habitat variables were sampled at base flow from three incised stream channels and one reference stream in northwest Mississippi, USA, to quantify incision effects on fish habitat and provide a basis for habitat rehabilitation planning and design. Incised channels were sampled in spring and autumn; the reference channel was sampled only in the autumn. Incised channel habitat quality was inferior to the reference channel despite the presence of structures designed to restore channel stability. Incised channels had physical habitat diversity levels similar to a nonincised reference channel, but contained fewer types of habitat. At base flow, incised channels were dominated by shallow, sandy habitats, moderate to high mean local Froude numbers, and had relatively little organic debris in their beds. In contrast, the reference stream had greater mean water depth, contained more woody debris, and provided more deep pool habitat. Fish assemblages in incised channels were composed of smaller fishes representing fewer species relative to the reference site. Fish species richness was directly proportional to the mean local Froude number, an indicator of the availability of pool habitat.     

Life hung by a thread: endurance of Antarctic fauna in glacial periods

Today, Antarctica exhibits some of the harshest environmental conditions for life on Earth. During the last glacial period, Antarctic terrestrial and marine life was challenged by even more extreme environmental conditions. During the present interglacial period, polar life in the Southern Ocean is sustained mainly by large-scale primary production. We argue that during the last glacial period, faunal populations in the Antarctic were limited to very few areas of local marine productivity (polynyas), because complete, multiannual sea-ice and ice shelf coverage shut down most of the Southern Ocean productivity within today's seasonal sea-ice zone. Both marine sediments containing significant numbers of planktonic and benthic foraminifera and fossil bird stomach oil deposits in the adjacent Antarctic hinterland provide indirect evidence for the existence of polynyas during the last glacial period. We advocate that the existence of productive oases in the form of polynyas during glacial periods was essential for the survival of marine and most higher-trophic terrestrial fauna. Reduced to such refuges, much of today's life in the high Antarctic realm might have hung by a thread during the last glacial period, because limited resources available to the food web restricted the abundance and productivity of both Antarctic terrestrial and marine life.     

DEMAND SIDE MANAGEMENT OF WATER IN ONTARIO MUNICIPALITIES: STATUS,PROGRESS, AND OPPORTUNITIES1

ABSTRACT: Demand side management is being used increasingly by Ontario municipalities as a way to improve the efficiency of water use, defer the costs associated with constructing new water treatment works, and minimize the environmental impacts associated with supplying water. A comprehensive survey of 153 Ontario municipalities was completed in mid‐1998. These ranged in size from small rural townships (with populations as low as 500 people) to the province's largest urban center, Metropolitan Toronto, with a population of approximately 2.5 million people. The questionnaire measured the use of six broad types of demand side measures, including water pricing and metering; municipal by‐laws (ordinances) that promote water conservation; operational and maintenance measures to reduce water losses and consumption; water‐saving plumbing fixtures and devices; public participation programs that encourage water conservation; and other measures, such as water audits. Additionally, the survey collected data on implementation barriers and opportunities. Since the last comprehensive Ontario survey, conducted in 1987 by Kreutzwiser and Fea‐gan (1989), there has been an increase in the use of basic tools such as metering and pricing, plumbing fixtures, and public participation programs. Additionally, new initiatives, such as water audits and computerized monitoring equipment, are being used. However, in many areas opportunities exist to make better use of demand side measures. Unfortunately, municipal capacity to do so often is constrained by (among other factors) limited finances, lack of political will, and public resistance. Demonstration of real cost savings to consumers, and the development of specific goals and objectives for demand side management programs, are two important steps needed to overcome these challenges.     

Population genetic structure of protected allis shad (<Emphasis Type="Italic">Alosa alosa</Emphasis>) and twaite shad (<Emphasis Type="Italic">Alosa fallax</Emphasis>)

Determining the magnitude of homing behaviour within migratory fish species is essential for their conservation and management. We tested for population genetic structuring in the anadromous alosines, Alosa alosa and A. fallax fallax, to establish fidelity of stocks to spawning grounds in the United Kingdom and Ireland. Considerable genetic differences were present among populations of both species, suggesting strong fidelity to breeding grounds and compatible with homing to natal origins. Moreover, the genetic structure of A. fallax fallax showed a clear pattern of isolation-by-distance, consistent with breeding populations exchanging migrants primarily with neighbouring populations. Spatial genetic differences were on average much greater than temporal differences, indicating relatively stable genetic structure. Comparing anadromous A. fallax fallax populations to the landlocked Killarney shad subspecies, A. fallax killarnensis (Ireland), demonstrated a long history of separation. These results demonstrating regional stock structure within the British Isles will inform practical management of stocks and their spawning habitats.     

Nitrogen in the Baltic Sea--policy implications of stock effects

We develop an optimal control model for cost-effective management of pollution, including two state variables, pollution stock and ecosystem quality. We apply it to Baltic Sea pollution by nitrogen leachates from agriculture. We present a sophisticated, non-linear model of leaching abatement costs, and a simple model of nitrogen stocks. We find that significant abatement is achievable at reasonable cost, despite the countervailing effects of existing agricultural policies such as price supports. Successful abatement should lead to lower nitrogen stocks in the sea in 5 years or less. However, the rate of ecosystem recovery is less certain. The results are highly dependent on the rate of self-cleaning of the Baltic Sea, and less so on the discount rate. Choice of target has a radical effect on the abatement path chosen. Cost-effectiveness demands such a choice, and should therefore be used with care when stock effects are present.     

Assessing potential risks to wildlife and sportsmen from exposure to dioxin in pulp and paper mill sludge spread on managed woodlands

Potential human and wildlife exposures to TCDD in landspread pulp and paper mill sludge in the State of Maine were evaluated by means of a human health and an ecological risk assessment methodology. The highest historical concentrations of TCDD reported for these sludges do not present a risk to American woodcock, selected as an indicator species for this analysis. Concentrations of TCDD as high as 50 ppt in soil are not likely to produce adverse effects in the embryonic/hatchling stage of the woodcock. This soil concentration of TCDD does not present a significant risk to sportsmen and their families that may consume birds which inhabit these sites.