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371.
Chemical synapses are highly specialized cell–cell junctions designed for efficient signaling between nerve cells. Distinct
cytoskeletal matrices are assembled at either side of the synaptic junction. The presynaptic cytomatrix at the active zone
(CAZ) defines and organizes the site of neurotransmitter release from presynaptic nerve terminals. The postsynaptic density
(PSD) tethers neurotransmitter receptors and the postsynaptic signal transduction machinery. Recent progress in the identification
and characterization of novel CAZ and PSD components has revealed new insights into the molecular organization and assembly
mechanisms of the synaptic neurotransmission apparatus. On the presynaptic side, Bassoon and Piccolo, two related giant proteins,
are crucially involved in scaffolding the CAZ. On the postsynaptic side, two families of multi-domain adaptor proteins, the
MAGuKs (membrane-associated guanylate kinase homologs) and the ProSAP (proline-rich synapse-associated protein, also termed
Shank) family members are thought to be major organizing molecules of the PSD. 相似文献
372.
Wir danken Dr. Kerndorff für die kritische Durchsicht des Manuskripts. 相似文献
373.
374.
We have determined the activity of alkaline phosphatase in chorionic villous tissue obtained in the first trimester of pregnancy, in order to obtain the normal range of values as a prerequisite for application to the prenatal diagnosis of the rare bone disease hypophosphatasia. The activities found were a combination of intestinal and liver/bone/kidney types; traces of placental type were present in only one sample. 相似文献
375.
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379.
The Mormon cricket, Anabrus simplex, is one of just a few species of katydids (or bushcrickets, Orthoptera: Tettigoniidae) that, like migratory locusts, appear
to have solitary and migratory morphs. Using radio telemetry we studied movements of individuals of two morphs of this flightless
species. Individuals within each migratory band had similar rates of movements along similar directional headings whereas
solitary individuals moved little and showed little evidence of directionality in movement. Our results also add to other
recent radio-telemetry studies showing that flightless insects of 1–2 g in mass can be tracked successfully using these methods.
Received: 28 February 2000 / Accepted in revised form: 19 June 2000 相似文献
380.
Hopanoids are pentacyclic triterpenoid lipids occurring in bacteria. They are synthesized from isopentenyl units which are
formed in a new biosynthetic route leading to isopentenyl diphosphate. Six C5 units are joined to form squalene, the immediate precursor in hopanoid synthesis. In a highly complex cyclization reaction
that shares considerable similarities with that of oxidosqualene to sterols, the hopane skeleton is formed from squalene by
the squalene-hopene cyclase. Recent elucidation of the X-ray structure of this membrane-bound cyclase has shed some light
on the properties of this unusual enzyme. The active site is located in a cavity within the enzyme. The squalene substrate
diffuses through a channel structure from the membrane into this cavity and is there transformed into hopene. Polar side chains
are attached to hopene resulting in the amphiphilic molecular structure of many hopanoids. These hopanoids are membrane components
involved in regulating membrane fluidity and stability. However, the many structural variants of hopanoids indicate that they
may have other interesting but as yet unknown functions. 相似文献