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排序方式: 共有216条查询结果,搜索用时 31 毫秒
51.
Leonard J. Sciorra Ph.D. Charles Hux Debra Day-Salvadore Ming-Liang Lee David E. Mandelbaum Sheila Brady-Yasbin Julie Frybury Maurice J. Mahoney Miriam Schoenfeld Dimaio 《黑龙江环境通报》1992,12(6):477-482
This paper reports a case of chromosomal mosaicism for trisomy 5 recovered from amniotic fluid cells and from skin fibroblasts of a liveborn dysmorphic male. Routine amniocentesis was performed at 16 weeks' gestation because of parental concern. Trisomy 5 cells were measured from 25 per cent of amniocytes from two culture vessels. No further invasive testing was performed until 32 weeks' gestation, at which time ultrasound examination showed fetus with intrauterine growth retardation. Fetal blood sampling was then performed, with only karyotypically normal cells recovered. At birth, the child was found to have multiple dysmorphic features and congenital anomalies, including an eventration of the diaphragm and ventricular septal defect, both of which required surgical correction. Chromosomal analysis of cord blood lymphocytes indicated 46,XY; however, 20 per cent of the cultured fibroblasts obtained from the chest skin at the incision site for diaphragmatic repair had a 47,XY,+5 karyotype. Trisomy 5 mosaicism may be another example of tissue-limited mosaicism. Fetal blood sampling can then be falsely reassuring. Furthermore, because some cell lines rarely appear in lymphocyte populations, cytogenetic analysis of multiple tissues warranted as part of the evaluation of individuals with developmental delay and dysmorphic features. 相似文献
52.
Leonard Ortolano 《Environmental Impact Assessment Review》1985,5(1):9-35
LEONARD ORTOLANO has written a textbook, Environmental Planning and Decision Making, that is ideal for introducing undergraduates to the field of environmental planning. His three chapters on environmental impact assessment (from 16 chapters overall) present a range of impact assessment methods in a helpful decision-making context. Specific techniques for considering biological factors in planning, evaluating the visual qualities of the environment, assessing noise impacts, assessing air quality impacts, and assessing impacts on water resources are also covered in five additional chapters. Professional planners and engineers should find this introduction to the approaches employed by specialists of various kinds helpful. With the permission of the publisher, John Wiley and Sons, we here reprint Chapter 15, “Estimating Air Quality Impacts,” from Ortolano's excellent book. This straightforward presentation of a six-step process for establishing the air quality impacts of proposed development projects is a model of clarity. 相似文献
53.
Luther V. Gibson Jr. Leonard K. Peters 《Journal of the Air & Waste Management Association (1995)》2013,63(3):218-223
The conventional gausslan plume equation for ground level concentrations was used to estimate hourly average sulfur dioxide concentrations at selected points in Louisville, KY, on specific days during 1973. Area emission sources were not included in the model since they are not substantial. The trajectory of the emissions from each continuous point source was calculated by a procedure that allowed for spatial variability in wind direction. All other meteorological parameters were held constant during each hour. The twenty-four individual hourly estimates at each location for a given day were arithmetically averaged yielding a daily mean. The model predictions were compared to actual measurements conducted by Jefferson County Air Pollution Control District personnel using the West-Gaeke sampling procedure. The sample correlation coefficient for all predictions was low, but after only about 30% of the predictions were eliminated on statistical grounds, the sample correlation coefficient was increased to 0.72. The statistical analysis appeared to discard a reasonable number of predictions on the basis of observed variability in the measured air quality. 相似文献
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55.
Maricica Pacurari Diane Schwegler-Berry Sherri Friend Steven S. Leonard Robert R. Mercer Val Vallyathan 《毒物与环境化学》2013,95(5):1045-1072
Single-walled carbon nanotubes (SWCNT) are being developed to be used in many industrial and biomedical applications. However, SWCNT's durability and likely fibrous morphology have raised health concerns. The present investigations were focused on understanding the cellular and molecular mechanisms induced by raw SWCNT (SWCNT) in human bronchial-epithelial cells (BEAS-2B). Asbestos (crocidolite) was used as a positive control. Exposure of BEAS-2B cells to SWCNT induced apoptosis, DNA damage, and oxidative stress. The generation of hydroxyl radical (?OH) and increase of superoxide dismutase (SOD) activity were concentration-dependent. The increase in apoptosis was associated with activation of caspase-3, caspase-7, and poly (ADP-ribose) polymerase-1 (PARP-1). A short recovery period of 6?h of cells from SWCNT exposure resulted in reversal of caspase-3 and caspase-7, and a partial reversal of PARP-1 activation. The activation of PARP-1, caspase-3, and caspase-7 was only partially diminished after a recovery of 6?h from the exposure to crocidolite. Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). SWCNT did not induce protein serine-threonine kinase (AKT) phosphorylation. For all the above end points, crocidolite induced a greater response compared to SWCNT. SWCNT induced a significant activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB), and the effect was inhibited by mitogen-activated protein kinase (MAPK) inhibitors. SWCNT also induced significant increase in the expression levels of c-Jun, βIGH3, and CD44 genes. The results of this study show that the molecular mechanism for raw SWCNT-mediated toxicity in BEAS-2B cells is through the activation of caspase-3, caspase-7, and PARP-1. Furthermore, the mechanism of AP-1 and NF-κB activation is through MAPK. This bioactivity of raw SWCNT is associated with the generation of oxidative stress and DNA damage. Considering the role of airway epithelium as a critical barrier for normal pulmonary function and focal point for tumor development, this study demonstrates that raw SWCNT activate molecular events which may be linked to adverse biological responses implicated in pulmonary diseases. 相似文献
56.
Eliza Kluckow Jane Halliday Alice Poulton Anthea Lindquist Briohny Hutchinson Michael Bethune Leonard Bonacquisto Fabricio Da Silva Costa Lucy Gugasyan James Harraway Amanda Howden Abhijit Kulkarni Nicole Martin Richard McCoy Melody Menezes Debbie Nisbet Ricardo Palma-Dias Mark D. Pertile Zeffie Poulakis Lisa Hui 《黑龙江环境通报》2019,39(13):1254-1261
57.
58.
Charles Brendecke Leonard Ortolano 《Journal of the American Water Resources Association》1981,17(2):248-254
ABSTRACT: Survey data from samples of two types of Corps of Engineers planning studies have been collected. The nature of significant environmental issues affecting the studies was ascertained. Information concerning District administrative practices and communication patterns and extraorganizational coordination procedures was also obtained. Statistical analysis examined the relationships between these practices and procedures and the consideration given environmental issues in plan formulation and modification decisions. Environmental issues receive greater consideration in plan formulation decisions where District policies encourage interdisciplinary planning and direct communication between planners and environmental interests. Plan modification decisions reflect environmental considerations to a greater degree where significant controversy exists and where reviewing agencies actively pursue environmental issues. 相似文献
59.
Leonard Ortolano Thomas P. Wagner 《Journal of the American Water Resources Association》1977,13(6):1131-1140
ABSTRACT: Public involvement in water resources planning is receiving much current attention, and there is a need to examine systematically how different public involvement techniques work in practice. The following techniques were among those used to involve the public in a recent Corps of Engineers’study of flooding on San Pedro Creek in Pacifica, California: a public workshop, citizen information bulletins (CIBs) and questionnaries. Interviews were held with 75 study participants to evaluate the effectiveness of these techniques. The interviews indicated that various study participants felt positively about the particular workshop format employed and about the use of a communications specialist to train workshop leaders. There were mixed reactions to the effectiveness of the CIBs and questionnaires. Although many individual citizens felt that the CIBs and questionnaires were useful, some of the Corps planners felt that CIBs and questionnaires would only be “cost-effective” on large studies and/or where the questionnaire response rate was high. The interviews led to a number of specific suggestions regarding how the extent of public involvement could be increased in future water resources planning studies. 相似文献
60.
Cascading ecological effects of low-level phosphorus enrichment in the Florida everglades 总被引:2,自引:0,他引:2
Gaiser EE Trexler JC Richards JH Childers DL Lee D Edwards AL Scinto LJ Jayachandran K Noe GB Jones RD 《Journal of environmental quality》2005,34(2):717-723
Few studies have examined long-term ecological effects of sustained low-level nutrient enhancement on wetland biota. To determine sustained effects of phosphorus (P) addition on Everglades marshes we added P at low levels (5, 15, and 30 microg L(-1) above ambient) for 5 yr to triplicate 100-m flow-through channels in pristine marsh. A cascade of ecological responses occurred in similar sequence among treatments. Although the rate of change increased with dosing level, treatments converged to similar enriched endpoints, characterized most notably by a doubling of plant biomass and elimination of native, calcareous periphyton mats. The full sequence of biological changes occurred without an increase in water total P concentration, which remained near ambient levels until Year 5. This study indicates that Everglades marshes have a near-zero assimilative capacity for P without a state change, that ecosystem responses to enrichment accumulate over time, and that downstream P transport mainly occurs through biota rather than the water column. 相似文献