Cadmium (Cd) has known to produce many adverse effects on organs including placenta. Many essential transporters are involved in Cd transport pathways such as DMT-1, ZIP as well as L-VDCC. Fourteen pregnant women participated and were divided into two groups: high and low Cd-exposed (H-Cd, L-Cd) groups on the basis of their residential areas, Cd concentrations in the blood (B-Cd), urine (U-Cd), and placenta (P-Cd). The results showed that the B-Cd and U-Cd were significantly increased in H-Cd group (p < 0.05). Interestingly, the P-Cd in H-Cd group was elevated (p < 0.05) and positively related to their B-Cd and U-Cd values (p < 0.05). However, the mean cord blood Cd (C-Cd) concentration in H-Cd group was not significantly increased about 2.5-fold when comparing to L-Cd group. To determine the Cd accumulation in placental tissues, metallothionein-1A (MT-1A) and metallothionein-2A (MT-2A) expressions were used as biomarkers. The results revealed that mean MT-1A and MT-2A mRNAs and MT-1/2 proteins were up-regulated in H-Cd group (p < 0.05). In addition, the Ca channel alpha 1C (CACNA1C) mRNA and protein expressions were noticeably elevated in H-Cd group (p < 0.05). From these findings, we suggested that CACNA1C might be implicated in Cd transport in human placenta. 相似文献
Benzo[a]pyrene (B[a]P) is an environmental toxicant and endocrine disruptor. Therefore, the aim of the present study was to investigate the toxicity of B[a]P in testis of rats and also to study the role of silymarin and thymoquinone (TQ) as natural antioxidants in the alleviation of such toxicity. Data of the present study showed that levels of testosterone, estrogen and progesterone were significantly decreased after treatment of rats with B[a]P. In addition, B[a]P caused downregulation of the expressions of steroidogenic enzymes including CYP17A1 and CP19A1, and decreased the activity of 17-β hydroxysteroid dehydrogenase (17β-HSD). Moreover, B[a]P decreased the activities of antioxidant enzymes including catalase (CAT), glutathione peroxidase (GPX) and superoxide dismutase (SOD), and significantly increased free radicals levels in testis of male rats. However, pretreatment of rats with silymarin prior to administration of B[a]P was found to restore the level of free radicals, antioxidant status, and activities of steroidogenic enzymes to their normal levels in testicular tissues. Moreover, histopathological finding showed that silymarin recovered the abnormalities occurred in tubules caused by B[a] P in testis of rats. On the other hand, TQ showed pro-oxidant effects and did not ameliorate the toxic effects of B[a] P on the testicular tissue since it decreased antioxidant enzymes activities and inhibited the protein expression of CYP11A1 and CYP21A2 compared to control rats. Moreover, TQ decreased the levels of testosterone, estrogen, and progesterone either in the presence or absence of B[a]P. It is concluded that B[a]P decreased testosterone levels, inhibited antioxidant enzymes activities, caused downregulation of CYP isozymes involved in steroidogenesis, and increased free radical levels in testis. Moreover, silymarin was more effective than TQ in restoring organism health and alleviating the deleterious effects caused by B[a]P in the testis of rats. Due to its negative impact, it is highly recommended to limit the use of TQ as a dietary supplement since millions of people in the Middle East are using it to improve their health.
Environmental Science and Pollution Research - The objective of this study was to monitor a newly constructed wetland (CW) in north Wales, UK, to assess whether it contributes to an improvement in... 相似文献
Climate change generally requires species to migrate northward or to higher elevation to maintain constant climate conditions, but migration requirement and migration capacity of individual species can vary greatly. Individual populations of species occupy different positions in the landscape that determine their required range shift to maintain similar climate, and likewise the migration capacity depends on habitat connectivity. Here, we demonstrate an approach to quantifying species vulnerabilities to climate change for 419 rare vascular plants in Alberta, Canada, based on a multivariate velocity of climate change metric, local habitat fragmentation, and migration capacity. Climate change velocities indicated that future migration requirements ranged from 1 to 5 km/year in topographically complex landscapes, such as the Alberta Foothills and Rocky Mountains. In contrast, migration requirements to maintain constant climate in relatively flat Boreal Plains, Parkland, and Grassland ranged from 4 to 8 km/year. Habitat fragmentation was also highest in these flat regions, particularly the Parkland Natural Region. Of the 419 rare vascular plants assessed, 36 were globally threatened (G1–G3 ranking). Three globally threatened species were ranked as extremely vulnerable and five species as highly vulnerable to the interactions among climate change velocity, habitat fragmentation, and migration capacity. Incorporating dispersal characteristics and habitat fragmentation with local patterns in climate change velocity improves the assessment of climate change threats to species and may be applied to guide monitoring efforts or conservation actions. 相似文献
This paper contributes to an enhanced understanding of present climatic conditions, observed climate trends and regional climate vulnerability of the Bhutan Himalayas. Bhutan’s complex, often high-altitude terrain and the severe impact of the Indian summer monsoon leads to a strong exposure of the countries’ key economic sectors (agriculture, forestry, hydropower generation and tourism) to climatic changes. Climate change also threatens Bhutan’s vast biodiversity and increases the likelihood of natural hazards (e.g. glacier lake outburst floods, flash floods, droughts and forest fires). A better understanding of Bhutan’s climate and its variability, as well as observed and possible climate impacts, will help in improving the handling of regional social, economic and ecologic challenges not limited to the Himalayas. Only a few climatological studies exist for the eastern Himalayas. They mainly focus on adaptation to immediate threats by glacier lake outbursts. In contrast, this paper (1) investigates the average spatial and inner-annual diversity of the air temperature regime of Bhutan, based on local meteorological observations, (2) discusses past temperature variability, based on global datasets, and (3) relates effects of observed warming to water availability, hydropower development, natural hazards, forests, biodiversity, agriculture, human health and tourism in the Bhutan Himalayas. Results indicate a large spatial and temporal temperature variability within Bhutan and considerably increasing temperatures especially over recent decades. Implications of regional climatic changes on various socio-economic sectors and possible adaptation efforts are discussed. 相似文献
Although the coastal salt marshes of Arabian Gulf have been altered extensively by human development activities, there is a paucity of data describing changes in the distribution and abundance of native coastal plant communities. The main objectives of this study are to determine vegetation condition, size structure, and conservation status of Nitraria retusa, a medicinal and salt-tolerant shrub, in disturbed and non-disturbed coastal salt marshes of Kuwait. Size measurements of Nitraria shrubs and nabkas, which are mounds of sediment developed around shrubs, were carried out in 50 quadrats (20 × 20 m2), randomly selected inside and outside Sabah Al-Ahmad Natural Reserve. Species richness and soil properties of nabkas and interspaces, the open areas between the nabkas, were also measured. The results revealed that nabkas of Nitraria in non-disturbed sites are more stable and rich in plant diversity than those in disturbed sites. Mean height and mean canopy diameter of Nitraria shrubs, total plant cover, and species richness are significantly higher in non-disturbed sites than disturbed sites, which indicate the positive influences of conservation for long term on vegetation structure and species richness. The results of soil analyses indicate the important role of nabkas in providing refuges for plant life and species diversity. The present study indicates that more than 50 % of the N. retusa community has been lost during the last few decades. Therefore, N. retusa should be considered an endangered species in Kuwait. The reduction in vegetation cover, a decline in species richness, and the overall degradation of salt marshes are attributed to human development activities along the coast of Kuwait. Effective conservation actions for threatened species in degraded coastal salt marshes of this region include establishment of protective enclosures, prohibitions on development that adversely affects native plant communities, and the planting native salt-tolerant shrubs to facilitate regeneration. 相似文献
Smallholder farmers play an important part in the dairy value chain in Sub-Saharan Africa. Three technological approaches have been used to improve productivity. These are through, applying agricultural ecological processes (ecological intensification), utilising modern livestock breeding (genetic intensification), and socio-economic intensification. Ecological intensification includes continuous housing of cows applying a cut-and-carry feeding system, introduction of purpose-bred forages and pastures, and the introduction of agro-forestry within the dairy systems. Genetic intensification strategies include: importation of dairy breeds such as Holstein–Friesian (HF) and cross-breeding of the indigenous breeds with HF. Training and capacity-building activities to create sustainable livelihoods have been initiated for farming and technological practices of animal husbandry, but also to enhance appropriate leadership and corporative-building skills that would create and support an enabling environment for sustainability. These improvements and initiatives in the service delivery have been championed by national governments, development partner institutions, or non-governmental organisations through different programmes. Challenges of intensification include matching management to genetic potential of imported and cross-bred improved dairy breeds, ensuring low post-harvest losses, proper utilisation, and reducing environmental impact. Using examples from Kenya, Malawi, Mozambique, Tanzania, and Zambia, this paper reviews the management and assessment approaches used in fostering smallholder dairy development strategies and dairy’s contribution to sustainable livelihoods in the face of intensification. 相似文献
In view of past environmental degradation and anticipated climate change impacts, we assessed the potential for ecosystem-based adaptation in the Murray-Darling Basin, Australia. In a workshop with staff from three Catchment Management Authorities (CMAs) who had jurisdiction over three sub-basins, as well as technical experts, nine adaptation options were identified that ranged from environmental flows, restoring river channel habitat, reoperating infrastructure and controlling invasive species. A Catchment Adaptation Framework was developed and used to assess and compare these adaptation options with each of the CMAs, drawing on interviews with their key stakeholders, to identify the risks, benefits and costs. We found that ecosystem-based adaptation can augment catchment management programs and requires investment in a suite of different but complementary measures to lower risk. Our research found institutional challenges in implementing this approach, including the complexities of multi-agency management, constricting legal requirements, narrow funding arrangements, under-developed institutional capacity, difficulties of implementing catchment-scale programs on private property and the need to adhere to community expectations. These institutional issues are ubiquitous internationally and point to the wider issues of providing sufficient management capacity to support adaptation. The Catchment Adaptation Framework presented here enables river basin managers to systematically assess the adaptation options to better inform their decision-making. 相似文献
Longer-term environmental studies are increasingly used to better understand contemporary ecosystems conditions and for forecasting their future trajectories. Here, we use radiometric measurements and the characterisation of sediment properties from six mountain and a lowland lake in Central Eastern Europe with the aim to assess temporal and spatial variability in sediment accumulation rates (SARs) in relation to three socio-economic regimes: traditional (1840–1948), socialist (1948–1989) and post-socialist (post-1990). We also set out to determine reference conditions for these lakes i.e. conditions before significant human impact. Our results show a trend of increasing SARs from basal sediments (pre 1840) towards the present at only two sites. This contrasts with findings from Western and Central European lakes where SARs have predominantly increased from 1850 towards the top of cores. We highlight the differential impacts of the traditional, socialist and post-socialist periods on the SARs at these lakes. Lowland and mid-elevations lakes (n = 2) were most markedly impacted by the socialist period of land use regime; lakes from the southern Carpathians (n = 2) were more impacted in the traditional period (transhumance pastoral activities), whereas those from the north (n = 3) in the socialist and post-socialist periods (summer pastoralism). Results from our study show a continuous anthropogenic impact during the entire period considered, even in remote mountain areas. This suggests that a temporal frame of 100–150 years is too short to meaningfully register the reference conditions of these lakes. Furthermore, a predominantly natural state may not have existed for centuries in this region. 相似文献
This two-part study investigates household preferences and willingness to pay (WTP) for water quality improvement of the Swat River in Pakistan. First, a four-point Likert scale was used to rank preferences for water quality benefits without using any financial metric. Results show that households have comparatively strong preferences for non-use benefits. Second, a contingent valuation question was designed to determine WTP for adopting a management plan developed exclusively for water quality improvement in the Swat River. The estimated annual mean WTP per household for water quality improvement is $2.40 when donating to an NGO. Generalizing this value to households living in Swat Valley would generate up to $544,000 per year. The present value aggregate benefit for 15 years would be sufficient to cover the present value of aggregate costs to adopt the management plan. A mandatory program that would require paying for the management plan generates half the WTP compared to the voluntary plan, but is still sufficient to cover costs and may be more feasible than a voluntary program because payment is assured. 相似文献