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961.
Breast milk samples from 40 first-time mothers from the Pacific Northwest of the US and Canada were analyzed for polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs). Total PBDEs (summation operator PBDEs), calculated by summing values for the 12 PBDEs congeners analyzed, ranged from 6 to 321 ppb (lipid weight) (mean=96 ppb; median=50 ppb). In approximately 40% of the women (15/40), summation operator PBDEs>100 ppb lw in their milk, and four samples had levels >250 ppb lw. PBDE 47 was the dominant congener in most samples, whereas PBDE 153 was predominant in a few (3/40). summation operator PCBs were calculated by summing values for the 82 PCB congeners analyzed, and ranged from 49 to 415 ppb (lipid weight) (mean=147 ppb; median=126 ppb). approximately 30% of the mothers (13/40) have summation operator PBDEs> summation operator PCBs in their milk samples, and approximately 65% (25/40) have BDE 47>PCB 153 in breast milk samples, with BDE 47 averaging 3-fold greater levels than PCB 153. Clearly, the lower brominated PBDEs are surpassing PCBs as a major environmental concern in North America, and are likely affecting significant portions of the populations in these regions. PBDEs have become a major persistent organic pollutant. However, there are no positive correlations between levels of summation operator PBDEs and summation operator PCBs, or between levels of PBDE 47 and PCB 153, suggesting there may be some differences in exposure pathways for PBDEs and PCBs in humans. 相似文献
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Jingwen Hu Kai Zhang Matthew P. Reed Jenne-Tai Wang Mark Neal Chin-Hsu Lin 《Traffic injury prevention》2019,20(4):S97-S105
AbstractObjective: Analyses of crash data have shown that older, obese, and/or female occupants have a higher risk of injury in frontal crashes compared to the rest of the population. The objective of this study was to use parametric finite element (FE) human models to assess the increased injury risks and identify safety concerns for these vulnerable populations.Methods: We sampled 100 occupants based on age, sex, stature, and body mass index (BMI) to span a wide range of the U.S. adult population. The target anatomical geometry for each of the 100 models was predicted by the statistical geometry models for the rib cage, pelvis, femur, tibia, and external body surface developed previously. A regional landmark-based mesh morphing method was used to morph the Global Human Body Models Consortium (GHBMC) M50-OS model into the target geometries. The morphed human models were then positioned in a validated generic vehicle driver compartment model using a statistical driving posture model. Frontal crash simulations based on U.S. New Car Assessment Program (U.S. NCAP) were conducted. Body region injury risks were calculated based on the risk curves used in the US NCAP, except that scaling was used for the neck, chest, and knee–thigh–hip injury risk curves based on the sizes of the bony structures in the corresponding body regions. Age effects were also considered for predicting chest injury risk.Results: The simulations demonstrated that driver stature and body shape affect occupant interactions with the restraints and consequently affect occupant kinematics and injury risks in severe frontal crashes. U-shaped relations between occupant stature/weight and head injury risk were observed. Chest injury risk was strongly affected by age and sex, with older female occupants having the highest risk. A strong correlation was also observed between BMI and knee–thigh–hip injury risk, whereas none of the occupant parameters meaningfully affected neck injury risks.Conclusions: This study is the first to use a large set of diverse FE human models to investigate the combined effects of age, sex, stature, and BMI on injury risks in frontal crashes. The study demonstrated that parametric human models can effectively predict the injury trends for the population and may now be used to optimize restraint systems for people who are not similar in size and shape to the available anthropomorphic test devices (ATDs). New restraints that adapt to occupant age, sex, stature, and body shape may improve crash safety for all occupants. 相似文献
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Rhett D. Harrison Rachakonda Sreekar Jedediah F. Brodie Sarah Brook Matthew Luskin Hannah O'Kelly Madhu Rao Brett Scheffers Nandini Velho 《Conservation biology》2016,30(5):972-981
Although deforestation and forest degradation have long been considered the most significant threats to tropical biodiversity, across Southeast Asia (Northeast India, Indochina, Sundaland, Philippines) substantial areas of natural habitat have few wild animals (>1 kg), bar a few hunting‐tolerant species. To document hunting impacts on vertebrate populations regionally, we conducted an extensive literature review, including papers in local journals and reports of governmental and nongovernmental agencies. Evidence from multiple sites indicated animal populations declined precipitously across the region since approximately 1980, and many species are now extirpated from substantial portions of their former ranges. Hunting is by far the greatest immediate threat to the survival of most of the region's endangered vertebrates. Causes of recent overhunting include improved access to forests and markets, improved hunting technology, and escalating demand for wild meat, wildlife‐derived medicinal products, and wild animals as pets. Although hunters often take common species, such as pigs or rats, for their own consumption, they take rarer species opportunistically and sell surplus meat and commercially valuable products. There is also widespread targeted hunting of high‐value species. Consequently, as currently practiced, hunting cannot be considered sustainable anywhere in the region, and in most places enforcement of protected‐area and protected‐species legislation is weak. The international community's focus on cross‐border trade fails to address overexploitation of wildlife because hunting and the sale of wild meat is largely a local issue and most of the harvest is consumed in villages, rural towns, and nearby cities. In addition to improved enforcement, efforts to engage hunters and manage wildlife populations through sustainable hunting practices are urgently needed. Unless there is a step change in efforts to reduce wildlife exploitation to sustainable levels, the region will likely lose most of its iconic species, and many others besides, within the next few years. 相似文献
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Graham W. Prescott William J. Sutherland Daniel Aguirre Matthew Baird Vicky Bowman Jake Brunner Grant M. Connette Martin Cosier David Dapice Jose Don T. De Alban Alex Diment Julia Fogerite Jefferson Fox Win Hlaing Saw Htun Jack Hurd Katherine LaJeunesse Connette Felicia Lasmana Cheng Ling Lim Antony Lynam Aye Chan Maung Benjamin McCarron John F. McCarthy William J. McShea Frank Momberg Myat Su Mon Than Myint Robert Oberndorf Thaung Naing Oo Jacob Phelps Madhu Rao Dietrich Schmidt‐Vogt Hugh Speechly Oliver Springate‐Baginski Robert Steinmetz Kirk Talbott Maung Maung Than Tint Lwin Thaung Salai Cung Lian Thawng Kyaw Min Thein Shwe Thein Robert Tizard Tony Whitten Guy Williams Trevor Wilson Kevin Woods Alan D. Ziegler Michal Zrust Edward L. Webb 《Conservation biology》2017,31(6):1257-1270
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly regulated economy to a more decentralized and economically liberal democracy and is working to end a long‐running civil war. With these transitions in mind, we used a horizon‐scanning approach to assess the 40 emerging issues most affecting Myanmar's forests, including internal conflict, land‐tenure insecurity, large‐scale agricultural development, demise of state timber enterprises, shortfalls in government revenue and capacity, and opening of new deforestation frontiers with new roads, mines, and hydroelectric dams. Averting these threats will require, for example, overhauling governance models, building capacity, improving infrastructure‐ and energy‐project planning, and reforming land‐tenure and environmental‐protection laws. Although challenges to conservation in Myanmar are daunting, the political transition offers an opportunity for conservationists and researchers to help shape a future that enhances Myanmar's social, economic, and environmental potential while learning and applying lessons from other countries. Our approach and results are relevant to other countries undergoing similar transitions. 相似文献