Antenatal corticosteroids and outcomes in gastroschisis: A multicenter retrospective cohort study

Objective

In gastroschisis, there is evidence to suggest that gut dysfunction develops secondary to bowel inflammation; we aimed to evaluate the effect of maternal antenatal corticosteroids administered for obstetric reasons on time to full enteral feeds in a multicenter cohort study of gastroschisis infants.

Methods

A three center, retrospective cohort study (1992-2013) with linked fetal/neonatal gastroschisis data was conducted. The primary outcome measure was time to full enteral feeds (a surrogate measure for bowel function) and secondary outcome measure was length of hospital stay. Analysis included Mann-Whitney and Cox regression.

Results

Of 500 patients included in the study, 69 (GA at birth 34 [25-38] weeks) received antenatal corticosteroids and 431 (GA at birth 37 [31-41] weeks) did not. Antenatal corticosteroids had no effect on the rate of reaching full feeds (Hazard ratio HR 1.0 [95% CI: 0.8-1.4]). However, complex gastroschisis (HR 0.3 [95% CI: 0.2-0.4]) was associated with an increased time to reach full feeds and later GA at birth (HR 1.1 per week increase in GA [95% CI: 1.1-1.2]) was associated with a decreased time to reach full feeds.

Conclusion

Maternal antenatal corticosteroids use, under current antenatal steroid protocols, in gastroschisis is not associated with an improvement in neonatal outcomes such as time to full enteral feeds or length of hospital stay.     

Pesticide resistance externalities and optimal mosquito management

A simultaneous equation model of the behavior of a mosquito abatement district based on biological and economic data is presented. Results indicate high long term costs if heavy reliance on chemical pesticide control methods continue, due to a pesticide resistance buildup in the mosquito populations. Physical source reduction methods were shown to be more efficient both in the short and long run. A linear programming model is presented which optimizes the inix of chemical and physical control methods. Results indicate increasing costs of mosquito abatement as pesticide effectiveness declines.     

Seasonal concentrations of lead in outdoor and indoor dust and blood of children in Riyadh,Saudi Arabia

Because detrimental effects of exposure to lead (Pb) on human health have been observed, we previously investigated concentrations of Pb in water supplies and blood of adult residents of Riyadh, Saudi Arabia. The objectives of the present study were to: (1) examine seasonal rates of deposition of Pb in dust in several areas of Riyadh city, (2) measure concentrations of Pb in both outdoor and indoor dust, (3) compare concentrations of Pb in dust in Riyadh with those reported for other cities, and (4) quantify Pb in blood of children living in Riyadh. Mean, monthly deposition of PB in outdoor dust was 4.7 × 10¹ ± 3.6 tons km^?2, with a mean Pb concentration of 2.4 × 10² ± 4.4 × 10¹ μg/g. Mean, monthly deposition of Pb in indoor dust was 2.7 ± 0.70 tons km^?2, with a mean concentration of 2.9 × 10¹ ± 1.5 × 10¹ μg Pb/g. There was a significant (P < 0.01) correlation between concentrations of Pb in outdoor and indoor dust. There was no correlation between concentrations of Pb in indoor dust and that in blood of children of Riyadh, whereas there was a weakly significant (P < 0.05) correlation between concentrations of Pb in outdoor dust and that in blood of children. The mean (±SD) concentration of Pb in blood of children in Riyadh was 5.2 ± 1.7, with a range of 1.7–1.6 × 10¹ μg/dl. Concentrations of Pb in blood of 17.8 % of children in Riyadh were greater than 10 μg/dl, which is the CDC’s level of concern.     

Procedures for outlier detection in circular time series models

It is known that the occurrence of outliers in linear or non-linear time series models may have adverse effects on the modelling and statistical inference of the data. Consequently, extensive research has been conducted on developing outlier detection procedures so that outliers may be properly managed. However, no work has been done on the problem of outliers in circular time series data. This problem is the focus of this paper. The main objective is to develop novel numerical and graphical procedures for detecting these outliers in circular time series data.A number of circular time series models have been proposed including the circular autoregressive model. We extend the iterative outlier detection procedure which has been successfully used in linear time series models to the circular autoregressive model. The proposed procedure shows a good performance when investigated via simulation for the circular autoregressive model of order one. At the same time, several statistical techniques have been used to detect the change of preferred trend in time series data using SLIME and CUSUM plots. While the methods fail to indicate directly the outliers in circular time series data, we use the ideas employed to develop three novel graphical procedures for identifying the outliers. For illustration, we apply the procedures to a particular set of wind direction data. An agreement between the results of the graphical and iterative detection procedures is observed. These procedures could be very useful in improving the modelling and inferential processes for circular time series data.     

Economic assessment of dredging operations in Mobile Bay,USA and some additional notes on sustainable management of dredged material

This paper describes a study that was performed to determine the cost-effective method of dredging in Mobile Bay in the United States and to explore the possibility of utilizing the dredged materials in an environmentally sustainable way. An analysis of the historical cost and working time data for hopper dredging and pipeline dredging for Mobile Bay showed that there was not a substantial difference in unit costs between the two methods. However, while the disposal methods for dredged materials were taken into consideration, the pipeline dredging seemed to be a more desirable and environmentally friendly option for dredging in Mobile Bay. In addition to cost analysis, the paper discusses several possible ways of sustainable management of dredged materials. The paper also indicates that if the sediment in Mobile Bay is found to be contaminated by the Deepwater Horizon oil spill, the pipeline dredging will become a more desirable dredging alternative.     

Occupational injuries and health problems in the Egyptian Mediterranean fisheries

Marine fishing is one of the most dangerous occupations. So far, no studies addressing occupational safety and health in the Egyptian fisheries have been conducted. The objective of this study is to explore and identify the types and causes of, as well as some factors associated with, occupational accidents and illnesses in the Egyptian marine fisheries. A sample of 686 fishermen in El-Maaddiya fishing port were interviewed for collecting relevant data. This paper presents the types of injuries mentioned by the interviewed fishermen and their potential causes in terms of accident type and involved agency/agency part. Also, major health problems and potential causes are presented. Furthermore, a logistic regression analysis was performed to study the significance of the association of some factors, such as age, experience, education and fishing gear with the occurrence of injuries and illnesses. The results of this study show that the Egyptian fishing industry involve many hazardous work conditions and practices that result in high morbidity and mortality rates, and high injury rates. The study recommends further research on suitable measures for the management of this problem.     

Field evaluation of intensive compost application on Cd fractionation and phytoavailability in a mining-contaminated soil

A field experiment was conducted to investigate the effect of chicken manure compost on the fractionation of cadmium (Cd), soil biological properties and Cd uptake by wheat in a soil affected by mining activities in Hubei province, China. Compost was applied at five levels (0, 27, 54, 108, 216 t ha^?1), and winter wheat (Triticum aestivum L.) was chosen as an indicator plant. Results showed that the application of compost increased soil pH and the content of total phosphorus and organic matter. Soil biological properties such as microbial biomass carbon, invertase, protease, urease and catalase activities were significantly enhanced by 0.24–3.47 times after compost application. Sequential extraction indicated that compost amendments decreased the acid-extractable Cd by 8.2–37.6 %, while increased the reducible and oxidisable Cd by 9.2–39.5 and 8.2–60.4 %, respectively. The addition of 27–54 t ha^?1 compost reduced Cd content in wheat stems and seeds by 69.6–75.0 % and 10.3–18.4 %, respectively. However, only 25.5–26.5 % reductions in Cd content in wheat stems were observed in 108–216 t ha^?1 compost amendments, and no significant decrease was detected for seeds. This study suggests that although compost is a suitable organic amendment to improve soil fertility and biological activities, the addition of compost should be moderated by an appropriate rate to optimize the use of compost for the reclamation of metal-contaminated soils at field scale.