First-trimester prenatal diagnosis of Sanfilippo C disease

At 10 weeks' gestation, chorionic villus biopsy was obtained from a woman at risk for Sanfilippo type C disease. Acetyl-CoA: α-glucosaminide N-acetyltransferase activity was markedly deficient. The pregnancy was terminated at 12 weeks' gestation and follow-up study on fetal fibroblasts confirmed the diagnosis.     

Cadmium in naturally-occurring water hyacinths

Water hyacinth [$\text{Eichhornia}$$\text{crassipes}$ (Mart.) Solms] is an effective fertillizer, mulch, soil amendment and fodder for cattle and sheep. The consequences of the ability of the plant to accumulate heavy metals needs consideration. Small and large water hyacinth ecotypes collected from two “rural” rivers in Florida, the Peace and Withalachoochee respectively, were examined for an accumulation of cadmium from the natural environment. Less than trace amounts (below limits of detection, 2.5ppb) were present. Water hyacinths tested for cadmium accumulation under laboratory conditions exhibited a pronounced ability to absorb and accumulate the metal. The roots contained 0.982 mg of the 2.0 mg cadmium presented to the plant. The distribution of the metal within the plant was 76.7% in the roots, 22.4% in the stems with the remainder in the leaves. Of the total cadmium presented to the plant, 80.8 ± 3.0% was recovered by the plant after 7 days, the mean generation time of the plant. With increasing urbanization, accumulation of cadmium by water hyacinths exists. It is either an asset or a potential hazard and needs to be appreciated.     

Accumulation of silver in the liver of three species of pinnipeds

Silver in the three species of pinnipeds [northern fur seal (Callorhinus ursinus), Steller sea lion (Eumetopias jubatus), and harbor seal (Phoca vitulina)] caught in the North Pacific Ocean were analyzed using inductively coupled plasma-mass spectrometry, in order to understand accumulation and distribution of silver in pinnipeds. In northern fur seals, relatively high concentrations of silver were observed in the liver and body hair. Some 70% of the silver burden was concentrated in the liver. Hepatic silver concentrations were significantly correlated to age in northern fur seals (r = 0.766, P < 0.001, n = 49) and Steller sea lions (r = 0.496, P < 0.01, n = 28). Levels of silver concentrations per wet weight (microgram g-1) in the three pinnipeds ranged from 0.04 to 0.55 for northern fur seals, from 0.1 to 1.04 for Steller sea lions and from 0.03 to 0.83 for harbor seals. Silver concentrations in liver for all pinnipeds were significantly correlated with mercury, and selenium (P < 0.001). Molar ratios between silver to selenium approximated 1:180 in northern fur seals, 1:120 in Steller sea lions, and 1:60 in harbor seals. The silver-mercury molar ratios were approximately 1:170 in northern fur seals, and 1:80 both in the other species. Increase in silver accumulation in the liver was caused by the retention in nuclei and mitochondria fraction together with mercury and selenium in the cells of northern fur seals.     

Hydroxyurea explosion: a thermoanalytical and calorimetric study

An accident occurred during a production process of hydroxyurea. Several thermoanalytical techniques were used in order to understand the reason for the accident, even utilising a simulation program. Thermogravimetric analysis and Fourier transform infra-red spectroscopy were performed to identify the decomposition products according to European Directive 96/82/EC, the so-called Seveso II.     

A System for Measuring Vertical Concentration Profiles of Gaseous Pollutants,Using Carbon Dioxide as a Case Study

An electronically-controlled sampling system, characterised by its organ pipe design, has been developed for sampling air sequentially, at different heights within the breathing zone. Data are automatically logged at the different receptor levels, for the determination of the average vertical concentration profile of gaseous pollutants. The system has been coupled to a carbon dioxide monitor and used in a brief study of the spatial and temporal variation of indoor carbon dioxide concentration. The system can easily be extended for different heights or modified for use with other types of gas monitor. The results of a trial run, which was carried out in a coffee room, are presented and applications of the Organ Pipe Sequential Sampling (OPSS) system are discussed.     

Relationship of safety climate perceptions and job satisfaction among employees in the construction industry: the moderating role of age

This study examines the degree to which construction sector employees perceive that safety is important in their organizations/sites and how job satisfaction affects these perceptions when age is introduced as a moderator variable. Two-way analysis of variance demonstrated that job satisfaction has a strong effect on perceived management commitment to work safety and that this relationship was moderated by respondents’ age. Job satisfaction was associated with perceived accident rate and safety inspection frequency, but the proposed role of age in this linkage was not confirmed. Consequently, the findings indicated that by increasing the level of job satisfaction, perceptions of these safety climate aspects proved to be more positive. The conclusion is that these relationships could further lead to a lower percentage of accidents and injuries in the workplace and better health among employees. A significant relationship between job satisfaction, age and perceived co-workers’ commitment to work safety was not found.     

City hazardous gas monitoring network

In our today's societies, many dangerous chemicals are produced and transported. Due to the vast use of chemicals, more chemical accidents are taking place with huge losses. In this study a city hazardous gas monitoring network was designed to detect the dispersion of toxic and combustible gases in the primary stages. The network could cover hazardous chemical facilities, important hazardous chemical routes, warehouses and special locations which may be the targets of terrorist attacks. The network is consisted of several local networks and a central control panel complex. Each local network has a local control panel in the center and many detectors and sounders around it at distances less than 3000 m that communicate with the local control panels wirelessly. In each location there are two types of gas detectors, toxic and combustible, and a sounder which are equipped with a wireless, radio frequency modem allowing the units to communicate readings and other information on a real-time basis with a remotely located local control panel. High sensitive Photo Ionization Detectors, PIDs, are used to provide fast and low-level on-site screening for chemicals contamination. Combustible gas detectors are the second choice to sense the combustible gas and verify the readings of PIDs in this regard. The central panel consists of several connected control panels work uniquely helping a computer set and the appropriate software and communicate with local control panels via telephone lines. All of the network components are shown on the monitor of central panel with special symbols by geographical information system program. The system is fully addressable so that the high level detection of a detector produces a blinking color double-circle around its symbol in GIS plan. In case of high level gas detection, a team of experts who are fully equipped with different portable detectors depart to the site to test the field to identify the chemicals. All readings of detectors are saved in a data bank and then analyzed to find any chemicals spills and leakages. The network was simulated by a special program so that the components of local networks and the central panel are shown in separate windows. By clicking on one detector on environmental window the formerly designed responses will be activated in central panel window.     

The crash severity impacts of fixed roadside objects

INTRODUCTION: This study analyzes the in-service performance of roadside hardware on the entire urban State Route system in Washington State by developing multivariate statistical models of injury severity in fixed-object crashes using discrete outcome theory. The objective is to provide deeper insight into significant factors that affect crash severities involving fixed roadside objects, through improved statistical efficiency along with disaggregate and multivariate analysis. METHOD: The developed models are multivariate nested logit models of injury severity and they are estimated with statistical efficiency using the method of full information maximum likelihood. RESULTS: The results show that leading ends of guardrails and bridge rails, along with large wooden poles (e.g. trees and utility poles) increase the probability of fatal injury. The face of guardrails is associated with a reduction in the probability of evident injury, and concrete barriers are shown to be associated with a higher probability of lower severities. Other variables included driver characteristics, which showed expected results, validating the model. For example, driving over the speed limit and driving under the influence of alcohol increase the probability of fatal accidents. Drivers that do not use seatbelts are associated with an increase in the probability of more severe injuries, even when an airbag is activated. IMPACT ON INDUSTRY: The presented models show the contribution of guardrail leading ends toward fatal injuries. It is therefore important to use well-designed leading ends and to upgrade badly performing leading ends on guardrails and bridges. The models also indicate the importance of protecting vehicles from crashes with rigid poles and tree stumps, as these are linked with greater severities and fatalities.