Genetic amniocentesis: 505 cases performed before the sixteenth week of gestation

Between May 1987 and November 1988, 505 early amniocentesis within the 15th week of gestation were performed at the First Department of Obstetrics and Gynaecology,‘L. Mangiagalli’ of the University of Milan and at the Department of Obstetrics and Gynaecology of ‘Gaslini’ hospital in Genoa. A total number often abnormal fetal karyotypes were diagnosed. In addition, one case of pseudomosaicism (not confirmed on fetal blood) and one case of osteogenesis imperfecta type II (observed at ultrasound examination) were also detected. Eleven pregnancies were therefore terminated because of an abnormal fetus. Out of 494 pregnancies (excluding terminated pregnancies) there were 16 fetal losses within the 28th week; ten of these occurred in the 2 weeks following the procedure. There were 475 live-births, of which 447 were term deliveries and the other 28 deliveries occurred before the 37th week of gestation.     

Process design for the environment: A multi-objective framework under uncertainty

Designing chemical processes for the environment requires consideration of several indexes of environmental impact including ozone depletion, global warming potentials, human and aquatic toxicity, photochemical oxidation, and acid rain potentials. Current methodologies, such as the generalized waste reduction algorithm (WAR), provide a first step towards evaluating these impacts. However, to address the issues of accuracy and the relative weights of these impact indexes, one must consider the problem of uncertainties. Environmental impacts must also be weighted and balanced against other concerns, such as their cost and long-term sustainability. These multiple, often conflicting, goals pose a challenging and complex optimization problem, requiring multi-objective optimization under uncertainty. This paper will address the problem of quantifying and analyzing the various objectives involved in process design for the environment. Towards this goal, we proposed a novel multi-objective optimization framework under uncertainty. This framework is based on new and efficient algorithms for multi-objective optimization and for uncertainty analysis. This approach finds a set of potentially optimal designs where trade-offs can be explicitly identified, unlike cost-benefit analysis, which deals with multiple objectives by identifying a single fundamental objective and then converting all the other objectives into this single currency. A benchmark process for hydrodealkylation (HDA) of toluene to produce benzene modeled in the ASPEN simulator is used to illustrate the usefulness of the approach in finding environmentally friendly and cost-effective designs under uncertainty.     

Raumbezug in der ökosystemaren Umweltbeobachtung

Using the example of the transboundary Biosphere Reserve Rhone, experiments were performed and expounded upon with regard to the concept of ‘integrated monitoring’. The paper describes the components of a step-by-step harmonisation of data sampling and analysis procedures. Special emphasis is given to topics dealing with suitable methods for a sound selection of areas and plots to be monitored, as well as on rules for the spatial integration and generalisation of sampling results. As tools for this purpose the concept of ‘integrated monitoring’ uses the federal ‘Classification System of Ecoregions’ (Standortökologische Raumgliederung) and geostatistical methods for the spatial integration of existing monitoring programmes and sampling grids. Further, the paper outlines how to judge the development of water catchment areas using existing data from hydrological analyses and by means of an ecosystem-oriented water balance model.     

Chemical trail communication in the amblyoponine species Mystrium rogeri Forel (Hymenoptera, Formicidae, Ponerinae)

Summary. Workers of the amblyoponine species Mystrium rogeri employ trail communication during recruitment to food sources and new nest sites. The trail pheromone originates from a hitherto unknown sternal gland located in the 7th abdominal sternite. The recruiting ant deposits the gland secretions by a special gaster-dragging behavior. The recruitment behavior can be complemented by a rapid vertical body shaking performed by some recruiting ants inside the nest. M. rogeri workers possess a large pygidial gland, the secretion of which elicits a repellent response in other ant species. Received 25 May 1998; accepted 15 June 1998.     

Prenatal diagnosis and psychological distress: Amniocentesis or chorionic villus biopsy?

The psychological reactions of 211 women undergoing prenatal diagnosis (PND) with amniocentesis (group A, n = 122) or chorionic villus biopsy (group V, n = 90) were exmained by questionnaires and interviews. The distress experienced while waiting for the test, during the test procedure, and while waiting for the result was reported by the women, both in questionnaires and in interviews. In the questionnaires, no difference between the two diagnostic methods was observed. In the interviews, however, the women undergoing amniocentesis appeared significantly more distressed by the procedure. In group A 97 per cent and in group V 100 per cent wished a method which, like chorionic villus biopsy, could be used in the first weeks of pregnancy. The risk of miscarriage was, as described in other studies, regarded as a serious threat by the pregnant women.