Transabdominal chorionic villus sampling in the second trimester of pregnancy: Feto-maternal transfusions in relation to pregnancy outcome

Volumes of feto-maternal transfusions (FMTs) in transabdominal chorionic villus sampling (TACVS) in the second trimester of pregnancy were calculated from the difference between maternal alpha-fetoprotein (AFP) concentrations before and 1 h after TACVS. In 50 pregnancies, there existed no correlation between FMT volume and the amount of villi collected or the number of TACVS attempts. The expected risk of fetal exsanguination due to very voluminous FMT could not be substantiated. In one case, immunization could have been the cause of hydrops fetalis, although only a volume of 0.15 ml could be calculated.     

Minute chromatin structures in cells of amniotic fluid—an interpretative dilemma

Single copies of tiny chromosome fragments, appearing either as single or as double minutes, were observed in a high frequency in amniotic fluid cultures of five mothers who underwent prenatal testing because of advanced age. In four cases, the minutes had arisen de novo. The minutes were later confirmed in fetal skin following termination of pregnancy in one case; in another, in cord blood following the birth of a normal boy; and in the third, in peripheral blood of a normal 3-year-old girl. In the fourth case, the minutes were not confirmed in cord blood following the birth of a normal boy. A follow-up chromosome study of the baby boy in the fifth case was not possible but the minutes were maternally transmitted.     

Transabdominal villus sampling in early second trimester: A safe sampling method for women of advanced age

Transabdominal chorionic villus sampling (TA-CVS) was performed in 707 viable singleton pregnancies to exclude chromosomal abnormalities. Maternal age ranged between 36 and 49 years (mean 37·9 years); gestational age varied between 10·2 and 18·3 weeks (mean 13·3 weeks). In 639 women (90·4 per cent), a sufficient amount of chorionic tissue (⩾ 10 mg) was obtained after one needle insertion; in 66 women (9·3 per cent) two insertions were needed. An abnormal chromosome pattern was established in 19 cases (2·9 per cent). Vaginal bleeding or spotting within 28 days after TA-CVS occurred in 11 cases (1·5 per cent). The completed follow-up of 678 chromosomally normal pregnancies showed an overall fetal loss rate of 2·6 per cent before 28 weeks. The overall perinatal mortality was 0·9 per cent. When relating fetal loss to gestational age at TA-CVS, this was 6·6 per cent in women sampled before 12 weeks against only 1·8 per cent after 12 weeks. At the same time, the percentage of fetal loss occurring within 2 weeks following the procedure was 75 and 30 per cent, respectively. It is suggested that these data reflect the decline in spontaneous abortion rate during this particular period of pregnancy. It is concluded that TA-CVS is an effective procedure which, when performed after the natural decrease of fetal loss, appears to be a safe option for women of advanced maternal age.     

Reducing the environmental impact of coal-washing practice in Australia

All Australian coal for export is washed — that is, the low-grade high-ash material is separated out and disposed of at the washery site. The coarse rejects are generally placed in embankments and the tailings are pumped into settling ponds. These methods of waste disposal can create environmental problems. In addition, they represent a significant energy loss, because about one-third of the waste material is combustible and is thus a potentially valuable source of energy. Laboratory studies at the CSIRO Division of Fossil Fuels at North Ryde, New South Wales, have shown that energy can be successfully recovered from washery wastes by the process of fluidized-bed combustion. A pilot fluidized-bed combustor, with a capacity of 2 tonnes/hour, is undergoing prolonged trial at the Clutha washery near Camden, New South Wales, in a joint project between the Joint Coal Board and CSIRO. The results from the pilot plant tests have provided the basis for a conceptual design and feasibility study for a full-scale tailings treatment plant. This study has indicated that fluidized-bed combustion:

1. offers an environmentally attractive and economically competitive alternative to the disposal of tailings in settling ponds, and
2. can be used to generate large quantities of energy from the wastes, reducing the energy lost in coal washing from around 16% to 6% of the coal mined.

     

Nitrates and gastric carcinogenesis

Nitrate, acting as a precursor in the formation of carcinogenicN-nitroso compounds, may be implicated in human digestive tract cancers. This study compares nitrate levels in drinking water with subsequent gastric cancer mortality in Kent, south-east England. The data suggest that water nitrate cannot be excluded as an aetiological factor, although other environmental variables must also be considered.     

Environmental aspects of mineral sand mining in Australia

The operations of the heavy mineral sand mining industry in Australia are reviewed, with particular emphasis on the environmental aspects. Pre-mining environments, state and commonwealth legislative requirements, mining procedures and postmining rehabilitation and land use are described. The extraction of heavy minerals, principally rutile, zircon, ilmenite and monazite, is concentrated on the east coast between the Hawkesbury River in New South Wales and Rockhampton in Queensland; and on the west coast at Capel, south of Perth and at Eneabba, north of Perth. The industry, especially on the east coast, has suffered from conservationist and anti-mining movements during the 1970s because it operates on or near the coastline where the majority of Australians live or seek their recreation. This was less of a problem on the west coast because the deposits were inland. The future of the industry is good as long as a balance can be maintained between the interests of conservationists and the mining companies.