一种改进的多学习教与学优化算法

针对传统教与学算法在解决复杂多峰函数优化问题时,具有局部最优且搜索开发能力较差的缺点,提出了一种改进的多学习教与学优化算法,新算法为学员的每一维加入不同的教学因子,设计了基于学员均值比较的教师选择策略和向教师及学员学习的多学习策略。基于多个单峰和多峰函数的仿真结果表明,新算法跟传统的、改进的教与学算法相比,在稳定性、寻优精度和收敛速度方面更具优势。     

Utilisation of phosphorus nutrient content in industrial scale plasmid DNA production: a waste minimisation study

Human gene therapy is currently seeing an increase in the use of plasmid (pDNA)-based vectors as a preferred choice of vehicle for delivery of the therapeutic gene into the body. In this regard, the environmental impacts of the waste streams from the possible industrial scale manufacture of pDNA require more detailed assessment. In this study, an initial assessment was made of the nutrient phosphorus (P) inputs to four fermentation processes recommended for the industrial scale production of pDNA for the purposes of gene therapy. Phosphorus inputs to each of the four selected fermentation processes ranged from approximately 60 mg l^?1 up to 3000 mg l^?1 in the fresh media. However, the spent media waste from each of the processes exhibited only a minor reduction in the phosphorus concentrations indicating minimal uptake of P by the microorganisms. This unutilised excess level of phosphorus nutrient within the waste streams poses a strong potential for environmental impact. Waste minimisation studies were undertaken on one model fermentation process with the aim of reducing unnecessary phosphorus input. An optimised media containing a 98% reduction in added P to the media was developed. This phosphorus-minimised media had little quantitative effect upon cell biomass produced and no effect upon the quantity or quality of pDNA produced, relative to the control media. The reduction in P requirement results in an overall cost savings of 12% per fermentation batch, would simplify subsequent wastewater treatment and would contribute to slowing the depletion rate of a valuable, finite natural resource.     

The water vulnerability of metro and megacities: An investigation of structural determinants

Urban areas are becoming increasingly subject to and vulnerable to water‐related natural disasters. Urban areas are a kind of socio‐ecological system wherein the human development dynamics co‐evolve with the natural dynamics. Most of the literature is focused on the impact of natural disasters on human development; we evaluate the impacts of human development on natural disasters and present an analysis of this phenomenon in the context of megacities. The approach is exploratory and begins with the construction of a database on the 595 existing megacities in the world. Multifactor analysis is then used to determine the main characteristics of these megacities. Finally, three structural components (maturity, anthropization and centrality) are identified and then correlated with data on water‐related hazards, distinguishing groups of cities according to their structure and factors of vulnerability to water‐related risks.     

How democratic innovations realise democratic goods. Two case studies of area committees in the Netherlands

Participatory planning is becoming increasingly integral to governance. Numerous planning innovations are developed which aim to increase democratic legitimacy and improve decision making. This paper critically reflects on a typical Dutch innovation: the area committee. Based on two individual case studies, we investigate whether area committees realise democratic legitimacy in existing planning practices. Analytically, we focus on four democratic goods: inclusiveness, popular control, considered judgement and transparency. Based on the interdependencies between area committees and government structures we discuss the potential and dilemmas for the area committee to contribute to the democratic legitimacy of environmental policy and rural development.