Reporting and evaluation criteria as means towards a transparent use of ecotoxicity data for environmental risk assessment of pharmaceuticals

Ecotoxicity data with high reliability and relevance are needed to guarantee the scientific quality of environmental risk assessments of pharmaceuticals. The main advantages of a more structured approach to data evaluation include increased transparency and predictability of the risk assessment process, and the possibility to use non-standard data.In this collaboration, between the research project MistraPharma and the German Federal Environment Agency, a new set of reporting and evaluation criteria is presented and discussed. The new criteria are based on the approaches in the literature and the OECD reporting requirements, and have been further developed to include both reliability and relevance of test data.Intended users are risk assessors and researchers performing ecotoxicological experiments, but the criteria can also be used for education purposes and in the peer-review process for scientific papers. This approach intends to bridge the gap between the regulator and the scientist’s needs and way of work.     

Will the circle be unbroken: a history of the U.S. National Ambient Air Quality Standards

In celebration of the 100th anniversary of the Air & Waste Management Association, this review examines the history of air quality management (AQM) in the United States over the last century, with an emphasis on the ambient standards programs established by the landmark 1970 Clean Air Act (CAA) Amendments. The current CAA system is a hybrid of several distinct air pollution control philosophies, including the recursive or circular system driven by ambient standards. Although this evolving system has resulted in tremendous improvements in air quality, it has been far from perfect in terms of timeliness and effectiveness. The paper looks at several periods in the history of the U.S. program, including: (1) 1900-1970, spanning the early smoke abatement and smog control programs, the first federal involvement, and the development of a hybrid AQM approach in the 1970 CAA; (2) 1971-1976, when the first National Ambient Air Quality Standards (NAAQS) were set and implemented; (3) 1977-1993, a period of the first revisions to the standards, new CAA Amendments, delays in implementation and decision-making, and key science/policy/legislative developments that would alter both the focus and scale of air pollution programs and how they are implemented; and (4) 1993-2006, the second and third wave of NAAQS revisions and their implementation in the context of the 1990 CAA. This discussion examines where NAAQS have helped drive implementation programs and how improvements in both effects and air quality/control sciences influenced policy and legislation to enhance the effectiveness of the system over time. The review concludes with a look toward the future of AQM, emphasizing challenges and ways to meet them. The most significant of these is the need to make more efficient progress toward air quality goals, while adjusting the system to address the growing intersections between air quality management and climate change.     

Conceptual PHES-system models of the Aysén watershed and fjord (Southern Chile): testing a brainstorming strategy

The use of brainstorming techniques for the generation of conceptual models, as the basis for the integrated management of physical-ecological-social systems (PHES-systems) is tested and discussed. The methodology is applied in the analysis of the Aysén fjord and watershed (Southern Chilean Coast). Results show that the proposed methods can be adequately used in management scenarios characterized by highly hierarchical, experts/non-experts membership.     

Triphenyltin alters lipid homeostasis in females of the ramshorn snail Marisa cornuarietis

Molluscs are sensitive species to the toxic effects of organotin compounds, particularly to masculinisation. Both tributyltin (TBT) and triphenyltin (TPT) have been recently shown to bind to mollusc retinoid X receptor (RXR). If RXR is involved in lipid homeostasis, exposure to TPT would have an immediate effect on endogenous lipids. To test this hypothesis, the ramshorn snail Marisa cornuarietis was exposed to environmentally relevant concentrations of TPT (30, 125, 500 ng/L as Sn) in a semi-static water regime for 7 days. Percentage of lipids and total fatty acid content decreased significantly in TPT-exposed females while the activity of peroxisomal acyl-CoA oxidase, involved in fatty acid catabolism, increased. In addition, fatty acid profiles (carbon chain length and unsaturation degree) were significantly altered in exposed females but not in males. This work highlights the ability of TPT to disrupt lipid metabolism in M. cornuarietis at environmentally realistic concentrations and the higher susceptibility of females in comparison to males.     

Dynamics of land change: insights from a three-level intensity analysis of the Legedadie-Dire catchments,Ethiopia

Earlier studies on land change (LC) have focused on size and magnitude, gains and losses, or land transfers between categories. Therefore, these studies have failed to simultaneously show the complete LC processes. This paper examines LCs in the Legedadie-Dire catchments in Oromia State, Ethiopia, using land-category maps with intensity analysis (IA) at three points in time. We comprehensively analyze LC to jointly encompass the rate, intensity, transition, and process. Thirty-meter US Geological Survey (USGS) Landsat imagery from 1986, 2000, and 2015 (<?10% cloud) is processed using TerrSet-LCM and ArcGIS. Six categories are identified using a maximum likelihood classification technique: settlement, cultivation, forest, water, grassland, and bare land. Then, classified maps are superimposed on the images to statistically examine changes with an IA. Considerable changes are observed among categories, except for water, between 1986–2000 and 2000–2015. Overall land change occurred quickly at first and then slowly in the second time interval. The total land area that exhibited change (1st?≈?54% and 2nd?≈?51%) exceeded the total area of persistence (1st?≈?46% and 2nd?≈?49%) across the landscape. Cultivation and human settlements were the most intensively increased categories, at the expense of grassland and bare ground. Hence, when grassland was lost, it tended to be displaced by cultivation more than other categories, which was also true with bare land. Annual intensity gains were active for forest but minimal for cultivation, implying that the gains of forest were associated with in situ reforestation practices and that the gains in cultivation were caused by its relatively large initial area under a uniform intensity concept. This study demonstrates that IA is valuable for investigating LC across time intervals and can help distinguish dormant vs. active and targeted vs. avoided land categories.     

Are you an ambitious cyclist? Results of the cyclist profile questionnaire in Germany

Abstract

Objective: A number of studies have already grouped cyclists according to different aspects of their mobility behavior. This could be used e.g., to improve the bicycle infrastructure planning, to detect critical spots and, to reduce obstacles for cycling. This wide, preexisting, range of cyclist typologies usually concentrates on one or two influence factors and differs, content-wise, in both factors used, as well as, methodically. Based on existing cyclist typologies we extracted all possible influence factors to integrate them in one single questionnaire. The objective of this study, using an empirical, based approach, is to compare this typology of cyclists with existing ones, integrating all known influence factors of recent studies.

Methods: To address these issues, we conducted a Germany-wide online survey on cycling behavior, covering all relevant aspects we derived from both literature and especially, former cyclist typology studies including: social factors; the impact of environmental, individual; and route factors; as well as motives. The main goal was to identify distinct types of cyclists, and describe them as detailed as possible. The heterogeneous sample included a total of 10,294 responses.

Results: Using factor and cluster analyses, a multidimensional typology with four groups of cyclists was derived which were interpreted as: ambitious, functional, pragmatic, and passionate cyclists. In addition, socio-economic factors, cyclist’s motivation, and crash history were analyzed.

Conclusion: The results produced by grouping different characteristics of cyclists can lead to policy recommendations or communal bicycle traffic planning. Policy planners can estimate reactions of the different types on interventions and adjust their decisions which can serve to support already passionate cyclists or, encourage normally under-represented infrequent cyclists to cycle more. The extent of perceived safety plays here an important role in the classification, e.g., the handling of high-risk areas for crashes.