Estrogens are accumulating in environment and their e ects on a variety of reproductive processes and tumorigenesis were reported
by previous study, but the mechanism of estrogen promoting neoplasia was still not clear. F-box protein (FBP) is the component of E3
ubiquitin ligase which takes part in a variety of key biological processes. In this study, using mature male zebrafish, which are more
sensitive to estrogen treatment, we examined influence of 17 -ethinylestradiol (EE2) exposure on the expression of a series of hepatic
FBP genes, which take part in a variety of biological processes, including tumorigenesis. The influence of EE2 on the expression of
hepatic mRNA concentrations of FBP genes were quantified based on the expression of the optimal internal control gene in male
zebrafish after 7-day exposure to EE2, from a low-dose concentration (1 ng/L) to environmentally relevant concentrations (10, 100
ng/L). Our results showed that EE2 exposure reduced the expression of fbxl14a, fbxl14b, fbxo25 and -TRCP2b, but enchanced the
expression of skp2. While the alterations in fbxl2, fbxw7, fbxo9, -TRCP2a, fbxl18 and fbxo45 mRNA levels were not observed after
EE2 exposure. Thus, our results showed that the expression of hepatic FBP genes exhibited di erentially in male zebrafish exposed
EE2. The changes of the expression level of FBP genes induced by EE2 may be an important clue to elucidate the correlations of
estrogen and hepatic tumors. 相似文献
This study investigated the dissolution, aggregation, and reaction kinetics of silver nanoparticles (AgNPs) with the three types of water disinfectants (ultraviolet, sodium hypochlorite, and ozone) under the different conditions of pH, ionic strength, or humic acid (HA). The physicochemical changes of AgNPs were measured by using UV–Vis spectroscopy, transmission electron microscopy, and inductively coupled plasma optical emission spectrometer. The results showed that when AgNPs contacted the disinfectants, oxidative dissolution was the primary reaction. In addition, the reaction kinetics studies revealed that the reaction rate of AgNPs with disinfectants was significantly influenced by different disinfectants along with different pH and the presence of sodium nitrate and HA. Our research demonstrated the potential effect of disinfectants on AgNPs, which will improve our understanding of the fate of AgNPs in the disinfection processes in the water and wastewater treatment plant. 相似文献
In order to improve and establish the localized source profile of PM2.5 in Fuxin, the ashes under dust catcher were collected from four typical coal-fired power plants in Fuxin and twenty-eight components were measured. The source profile of PM2.5 in the soot of the four coal-fired power plants was established. SO42? was the most abundant component in the PM2.5 of the soot of the four coal-fired power plants, followed by Ca2+ and organic carbon (OC). The content of element components in PM2.5 smoke ranges from 5.06 to 10.97%, the content of ionic components ranges from 36.53 to 48.59%, and the total carbon content ranges from 9.43 to 11.36%. The divergence coefficient of PM2.5 source profile in Fuxin coal burning smoke is mostly similar to that of Fushun, whereas the divergence coefficient of Colorado reaches 0.65, indicating that Fuxin coal burning power plant smoke has no similarity to Colorado. The order of the geological accumulation index of Ni, Cu, V, Mn, and Cr was Cr (4.58) > Mn (4.42) > V (4.38) > Cu (4.09) > Ni (4.06), showing a heavy pollution level. The health risk assessment model recommended by the USEPA was used to assess the health risk of heavy metals in soot of coal-fired power plants, and the non-carcinogenic risk values of As for children and adults were 45.7 and 4.90, respectively. The carcinogenic risk values of Cr for adults and children were the highest, with values of 3.66 × 10?5 and 2.06 × 10?5, respectively, followed by As.