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71.
Many observations are reported that organic mercury compounds are involved in increasing intracellular Ca2+ levels. However, the issue of which substances on the cell membrane participate in the Ca2+ uptake that is induced by ethyl mercury is unclear. The findings of this study suggest that the P2X receptor participates in this process. The uptake of Ca2+ by C8-B4 cells was induced in the presence of ethyl mercury. Ca channels in the cell membrane were not affected in this process. In contrast, pretreatment with suramin, an antagonist of the P2X receptor, inhibited the Ca2+ uptake induced by ethyl mercury, and also brilliant blue G, a nonselective antagonist of P2×4, P2×5, and P2×7 receptors. In addition, A438079 and A740003, selective antagonists of P2×7 receptor, reduced Ca2+ uptake, while 5-BDBD, a selective antagonist of P2×4 receptor, did not. Furthermore, the mRNAs of both the P2×4 and P2×7 receptors were expressed in the presence of ethyl mercury, but the P2×5 receptor mRNA was not. These findings suggest that ethyl mercury may induce Ca2+ uptake through the P2×7 receptor of the cell membrane. 相似文献
72.
73.
Atsumi Miyake Hidefumi Kobayashi Hiroshi Echigoya Shiro Kubota Yuji Wada Yuji Ogata Hiroyuki Arai Terushige Ogawa 《Journal of Loss Prevention in the Process Industries》2007,20(4-6):584-588
To better understand the detonation characteristics of ammonium nitrate (AN) and activated carbon (AC) mixtures, steel tube tests were carried out for AN/AC mixtures of various compositions and different forms of AN (powdered, prilled, phase stabilized and granular), and the detonation velocity was measured. The powdered AN/AC mixtures gave higher detonation velocities than the other AN forms. For all the AN/AC mixtures, the experimentally observed detonation velocities at each loading density were far below the theoretically predicted values calculated by the CHEETAH code based on thermohydrodynamics, exhibiting so-called non-ideal detonation. The lowest detonation velocity of powdered AN/AC mixtures was obtained as D=1.25 km/s for an AC content of 0.1 wt%. This was considered to be close to the critical condition for stable detonation. 相似文献