Epidemiological studies have shown that particulate matter 2.5 (PM2.5) not only increases the incidence of cardiopulmonary illnesses but also relates to the development of neurodegenerative diseases. Considering that PM2.5 is highly heterogeneous with regional disparity and seasonal variation, we investigated whether PM2.5 exposure induced neuronal apoptosis and synaptic injuries in a season-dependent manner. The results indicated that PM2.5 altered the expression of apoptosis-related proteins (mainly bax and bcl-2), activated caspase-3 and caused neuronal apoptosis. Additionally, PM2.5 decreased the levels of synaptic structural protein postsynaptic density (PSD-95) and synaptic functional protein N-methyl-D-aspartate (NMDA) receptor subunit (NR2B) expression. These effects occurred in a season-dependent manner, and PM2.5 collected from the winter showed the strongest changes. Furthermore, the effect was coupled with the inhibition of phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) and phosphorylated cAMP-response element binding protein (p-CREB). Based on the findings, we analyzed the correlations between the chemical composition of PM2.5 samples and the biological effects, and confirmed that winter PM2.5 played a major role in causing neuronal apoptosis and synaptic injuries among different season samples. 相似文献
The detailed sorption steps and biodegradation characteristics of fluoroquinolones(FQs)including ciprofloxacin, enrofloxacin, lomefloxacin, norfloxacin, and ofloxacin were investigated through batch experiments. The results indicate that FQs at a total concentration of 500 μg/L caused little inhibition of sludge bioactivity. Sorption was the primary removal pathway of FQs in the activated sludge process, followed by biodegradation, while hydrolysis and volatilization were negligible. FQ sorption on activated sludge was a reversible process governed by surface reaction. Henry and Freundlich models could describe the FQ sorption isotherms well in the concentration range of 100–300 μg/L. Thermodynamic parameters revealed that FQ sorption on activated sludge is spontaneous, exothermic, and enthalpy-driven. Hydrophobicity-independent mechanisms determined the FQ sorption affinity with activated sludge. The zwitterion of FQs had the strongest sorption affinity, followed by cation and anion, and aerobic condition facilitated FQ sorption. FQs were slowly biodegradable, with long half-lives( 100 hr). FQ biodegradation was enhanced with increasing temperature and under aerobic condition,and thus was possibly achieved through co-metabolism during nitrification. This study provides an insight into the removal kinetics and mechanism of FQs in the activated sludge process, but also helps assess the environmental risks of FQs resulting from sludge disposal. 相似文献
In this paper we develop estimates of the economic effects of sea level rise on marine recreational shore fishing in North Carolina, USA. The relationship between angler behavior and spatial differences in beach width is estimated using the Marine Recreational Fishing Statistics Survey and geospatial data. We exploit the empirical relationship between beach width and fishing site choice by simulating the effects of sea level rise on angler site choice. We find that reductions in beach width negatively affect the quality and number of fishing trips even as anglers adapt by using piers and bridges. Welfare losses are potentially substantial, ranging up 39% of the total value of marine shore fishing in North Carolina. 相似文献
The development of eco-friendly cosmetic such as those from microalgae for skin regeneration and collagen synthesis has gained a great interest worldwide. Accordingly, the potential of microalgae biomass as source of anti-aging cosmetic cream with high antioxidant activity has been investigated. Stabilities and sensory characteristics of cosmetic creams supplemented with Spirulina, Tetraselmis sp. and Dunaliella sp. at 0.5, 1.5 and 2.5%, respectively, revealed a conservation of physico-chemical and preliminary stability properties of formulations. To analyze physico-chemical and textural parameters, accelerated stability study was evaluated under two thermal conditions (25 and 40 °C) during 90 days. Results showed that pH values of all formulations were within the limits of normal skin pH range under storage time at 25 and 40 °C. During this period, the colored creams showed a significant changes of a* and b* indices, reflecting the instability of microalgae colors. Microalgae modified the textural characteristics of emulsions. The Tetraselmis sp. containing-cream had the lowest (P < 0.05)?values of hardness, springiness, and cohesiveness. The 0.5% Spirulina containing-cream had the best stable consistency and adhesiveness under time and temperature variations. It exhibited the best properties to be used for skin care products. Thanks to their high content in bioactive macromolecules, microalgae considerably improved the antioxidant activity of the new formulated skin creams.
The present paper addresses defining the extent of the mixing zones of effluents discharged into rivers, which is a problem that should be analyzed based on probabilistic terms, as it is governed by several random processes. A river’s flow regime is one of the main variables, and it has a high dependence on hydrological processes. Additionally, after calculating the extent of the mixing zone, it is necessary to determine if the resulting dimensions are admissible or not. Common practice includes the admissibility criteria associated with the geometry of the river. However, this practice does not consider the environmental characteristics of the river that make it capable of absorbing the impact of the effluent (the biological and hydromorphological status of the river and the presence of structures that can change the river flow conditions, ecologically sensitive area or threatened species). This paper presents work on two important topics: on the one hand, the development of a methodology to establish the admissible extent of the mixing zone as a function of the environmental vulnerability of the river to the discharged effluent and, on the other hand, the proposal of a procedure to perform the calculations of the effluent mixing considering the variability of the river’s flow regime. The proposed methodological approaches are illustrated with an application to a real case, including a numerical simulation of the hydrodynamic and effluent evolution of the river during a year, to test the proposed methodology’s suitability and demonstrate the important savings in computational effort that can be achieved. 相似文献
Life cycle assessment (LCA) of waste treatment processes is often associated with considerable uncertainties. The aim of this study is to estimate the total uncertainty in the modelled composting system and the influence of material and process parameters on the uncertainty. Four composting combinations with fresh (FC) and mature substrate compost (MSC) from partially enclosed (PEC) and open composting (OC) were investigated. Perturbation analysis was used to determine the effect of parameters on the result and Monte Carlo simulation was used to estimate the total uncertainty. This study showed that the production of MSC using PEC had the lowest overall impacts across all impact categories except ozone depletion. Results of the Monte Carlo simulation showed that comparing composting options was challenging. The sensitivity ratios obtained from the perturbation analysis showed that the process parameter percentage of carbon fraction degraded was the most influential for FC. In MSC, the moisture content in the input material and the substitution factor used for peat were the most influential. Monte Carlo simulations demonstrated the overall uncertainty of the model and its relevance when comparing results between combinations. The perturbation analysis identified the parameters that required more accurate data to reduce the uncertainty in the model.
Journal of Material Cycles and Waste Management - Lemon peel waste (LPW) were pyrolysed in a laboratory fixed-bed reactor at final temperature of 300 °C, 400 °C and... 相似文献
Environmental Science and Pollution Research - The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors. In this context, a co-culture... 相似文献