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121.
Unexplained stillbirth is defined as a stillbirth with no known cause after the exclusion of common causes, including obstetric complications, infections, placental insufficiency or abruption, umbilical cord complications, and congenital abnormalities with or without known genetic cause. More than 60% of stillbirth cases remain unexplained. The aim of this systematic review was to investigate the known genetic causes of unexplained stillbirth cases and to evaluate the current position and future directions for the use of genetic and genomic testing in expanding the knowledge in this field. A systematic search through several databases was performed using the keywords genetics and stillbirths in humans. Different methods to detect various types of causal genetic aberrations have been used in the past decades, from standard karyotyping to novel methods such as chromosomal microarray analysis and next generation sequencing technologies. Apart from common chromosomal aneuploidies, a promising hypothesis about genetic causes included genes related to cardiomyopathies and channelopathies. However, these were tested in the research settings, since molecular karyotyping is currently the standard approach in the routine evaluation of genetic causes of stillbirth. Hereby, we provide evidence that expanding knowledge using novel genetic and genomic testing might uncover new genetic causes of unexplained stillbirth. 相似文献
122.
Uncertain future payoffs and irreversible costs characterize investment in climate change adaptation and mitigation. Under these conditions, it is relevant to analyze investment decisions in a real options framework, as this approach takes into account the economic value associated with investment time flexibility. In this paper, we provide an overview of the literature adopting a real option approach to analyze investment in climate change adaptation and mitigation, and examine how the uncertain impacts of climate change on the condition of the human environment, risk preferences, and strategic interactions among decisions-makers have been modeled. We found that the complex nature of uncertainties associated with climate change is typically only partially taken into account and that the analysis is usually limited to decisions taken by individual risk neutral profit maximizers. Our findings call for further research to fill the identified gaps.Electronic supplementary materialThe online version of this article (10.1007/s13280-020-01342-8) contains supplementary material, which is available to authorized users. 相似文献
123.
Environmental Fluid Mechanics - Aquatic vegetation is ubiquitous in lowland rivers, and it is typically present in the shape of spatial self-organized patches of biomass. In this work, we... 相似文献
124.
Joep P. M. Geraedts Joyce Harper Peter Braude Karen Sermon Anna Veiga Luca Gianaroli Noelle Agan Santiago Munné Sue Gitlin Elisabeth Blenow Kylie de Boer Nicole Hussey Emmanuel Kanavakis Soo-Huan Lee Stéphane Viville Lewis Krey Pierre Ray Serena Emiliani Yung Hsien Liu Stefan Vermeulen 《黑龙江环境通报》2001,21(12):1086-1092
An Erratum has been published for this article in Prenatal Diagnosis 22 (5) 2002, 451. Preimplantation genetic diagnosis (PGD) requires the combined efforts of geneticists and workers in the field of reproductive medicine. This was studied on the basis of a questionnaire, sent to 35 members of the PGD Consortium of the European Society of Human Reproduction and Embryology (ESHRE). A reply was obtained from 20 centres. They represent the majority of activities in the field of PGD in the world. It is obvious that many of the activities (in vitro fertilisation, embryo culture and biopsy) take place in IVF units while others (counselling and diagnosis) are the responsibility of genetic diagnostic centres. The distances between both units vary considerably. In all but one centre sex determination is offered. Aneuploidy screening is offered in 13 out of 20 centres. PGD of translocations and other structural chromosome abnormalities is offered in all but one centre. The number of monogenic diseases offered varies considerably. In comparison to prenatal diagnosis PGD is more expensive. The majority of these costs are due to the IVF or ICSI procedure. The charges for PGD vary between about € 600 and € 4000. In 16 out of 20 centres the parents to be must sign an informed consent form. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
125.
The present study compares the spatial distribution of selected rural land use classes in Italy with two soil indicators (a Soil Quality Index [SQI] and the Maximum potential Water Capacity of the soil [MWC]) at three points in time (1960, 1990 and 2006). Results of the analysis showed that landscape changes reflect a ‘migration’ of both semi-natural (forests, pastures) and agricultural (arable land, vineyards) uses towards areas with lower-quality soils. In particular, the agricultural ‘mosaic’ and shrubland-pasture classes that occupied land in 2006 had significant lower values of both the SQI and MWC compared to 1960. These processes may have implications for the stability of agro-forest ecosystems in the medium term. Due to its versatility, the procedure illustrated represents a monitoring tool for sustainable land management at the regional and country scales. 相似文献
126.
The social environment of many species includes synchronous maturation of siblings in family groups, followed by limited dispersal
of adults from their natal site. Under these conditions, females may experience high encounter rates with same-age siblings
during mate searching, increasing their risk of inbreeding. If inbreeding depression occurs, mating with a sibling is often
considered maladaptive; however, in some contexts, the inclusive fitness benefits of inbreeding may outweigh the costs, favoring
females that tolerate some level of inbreeding depression. We evaluated mating patterns in the treehopper Umbonia crassicornis, a semelparous species in which females encounter same-age siblings during mate searching. A female U. crassicornis that mates with a brother suffers from inbreeding depression. We used a free-choice mating design that offered females simultaneous
mating opportunities with three groups of males: siblings, same-age nonsiblings, and older nonsiblings. These groups represent
the types of males typically encountered by females during mate searching. Our goal was to assess whether mating patterns
were influenced by inbreeding avoidance by evaluating two hypotheses: kin discrimination and age-based mating (older males
cannot be siblings in this species). There was no difference in the proportions of females mating with siblings vs nonsiblings,
suggesting an absence of kin discrimination. However, females mated with a greater proportion of older vs younger males. Given
that females do not avoid siblings as mates despite a cost to inbreeding, our results provide a possible example of inbreeding
tolerance. We also discuss some factors that may have contributed to the mating advantage of older males. 相似文献
127.
Alessandro Franco Michele Lanzetta Luca Romoli 《Journal of Cleaner Production》2010,18(16-17):1722-1730
This paper presents an analysis of Selective Laser Sintering (SLS) from an energy standpoint. Selective Laser Sintering (SLS) has a potential as an environmental benign alternative to traditional processes but only few authors deal with the process optimisation including energy aspects. In the present paper an analysis of the energetic aspect of SLS is proposed. In addition, with respect to the classical technological parameters (resolution, productivity) attention is paid to energetic elements (energetic productivity, laser parameters) showing how the perspective of a sensible development of such a kind of technology could be beneficial not only from a technological point of view, but also for energy saving in a lot of manufacturing fields. A polyamide powder is the material tested to acquire some characteristics data of the process. It is shown that the Volumetric Energy Intensity (VEI) of the process in optimal condition could be of the order of 0.2 J for each mm3 of material agglomerated. 相似文献
128.
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130.
Landscape changes and environmental quality: the evolution of land vulnerability and potential resilience to degradation in Italy 总被引:1,自引:0,他引:1
Luca Salvati Ilaria Tombolini Luigi Perini Agostino Ferrara 《Regional Environmental Change》2013,13(6):1223-1233
Resilience, considered as the ability of a system to absorb and compensate pressures derived from human and natural systems, is a topic of interest in the Mediterranean region whose landscape is the joint result of social, economic and environmental factors. The present study analyses the changes in the Italian landscape over two periods (1960–1990 and 1990–2010) of the last 50 years through a composite index of environmental resilience and vulnerability to land degradation. Results indicate that the spatial distribution of this index has been considerably changed from a relatively simple geography (mainly reflecting a latitude gradient) to a more complex pattern. The level of vulnerability of southern Italian land maintained quite stable while increasing significantly in Northern and Central Italy. The (potential) resilience level decreased over time in Central and Northern Italy while growing moderately in Southern Italy. This means that important processes of environmental changes impacting landscape resilience occurred with a different spatial trend in Italy. The composite index derived from vulnerability and potential resilience estimates at the regional scale revealed crucial to map over time the increase of surface land exposed to desertification risk. Results support the adoption of measures promoting a sustainable land management in environmentally vulnerable land with low potential to resilience. 相似文献