Regulation of hepatocyte proliferation

After partial hepatectomy the low proliferation rate of hepatocytes increases dramatically. This is based on a feed-back system whose central link is a liver cell proliferation hormon, the so-called hepatopoietin. The hormon originates from the Peyer's patches: after their resection, the liver cell proliferation after partial hepatectomy decreases by about 80%. Hepatopoietin effects organ specific but species nonspecific.     

Modifying traditional and high-input agroecosystems for optimization of microbial symbioses: a case study of dry beans in Costa Rica

Optimization of symbioses between plants and microbes has been suggested as method for enhancing nutrient uptake in low-input agroecosystems. In generall symbioses may be maximized through: (1) the selection of plant cultivars responsive to symbiontss; (2) ionoculation with highly efficient strains of symbionts; (3) habitat modification to encourage symbioses. These methods were tested under a traditional, slash mulch, ‘frijol tapado’ en agroecosystem and/or a high-input (‘espequeado’) system to increase nodulation and vesicular-arbuscular mycorrbizae (VAM) of beans with the following results: (1) Under the espequeado system (modified by the exclusion of fertilizer application), four cultivars of indeterminate, vining dry beans (Phaseolus vulgaris) nodulated more than two determinate, bush varieties, especially under low available soil phosphorus (P). VAM levels were not statistically different under these conditions. (2) Under the tapado system, pelletization with rock phosphate and Rhizobium inoculum did not significantly change nodule biomass, dinitrogen (N₂)-fixation or yield. (3) Without P application, neither nodulation nor % VAM were significantly different between the two systems of bean production. However, as applied P increased, differences in %VAM of the two systems became significant, decreasing more sharply with increasing P in the tapado system.The tripartite symbiosis of beans can be influenced by various factors such as cultivar, nutrient application and production system. Although traditional varieties and systems may optimize certain microbial symbioses, the quantity of the symbiosis appears to depend on a number of complex factors. An intermediate agricultural technology, the mixing of traditional and modern, is exemplified here by the application of moderate levels of fertilizer to the tradional, tapado systems. This intermediate approach promises to decrease inputs in comparison to the espequedo system, as well as the need for shift cultivation, but long-term testing is needed.     

Molecular organization of excitatory chemical synapses in the mammalian brain

 Chemical synapses are highly specialized cell–cell junctions designed for efficient signaling between nerve cells. Distinct cytoskeletal matrices are assembled at either side of the synaptic junction. The presynaptic cytomatrix at the active zone (CAZ) defines and organizes the site of neurotransmitter release from presynaptic nerve terminals. The postsynaptic density (PSD) tethers neurotransmitter receptors and the postsynaptic signal transduction machinery. Recent progress in the identification and characterization of novel CAZ and PSD components has revealed new insights into the molecular organization and assembly mechanisms of the synaptic neurotransmission apparatus. On the presynaptic side, Bassoon and Piccolo, two related giant proteins, are crucially involved in scaffolding the CAZ. On the postsynaptic side, two families of multi-domain adaptor proteins, the MAGuKs (membrane-associated guanylate kinase homologs) and the ProSAP (proline-rich synapse-associated protein, also termed Shank) family members are thought to be major organizing molecules of the PSD.     

Optimising the environmental benefits of emission reductions from UK coal- and oil-fired power stations: a critical loads approach

This paper describes a method for determining reductions of SO₂ emissions from coal- and oil-fired power stations, oil refineries and large industrial units in the UK taking into account their pollution potential. The method is based on the use of two gridded data sets: critical loads, which represent the sensitivity of the environment to acid deposition and modelled estimates of total (wet + dry) sulphur deposition for 646 point sources within the UK. An iterative method is used to identify and subsequently reduce emissions from point sources that contribute most to areas of critical loads exceedance. This paper demonstrates how the method may be used to determine an optimal allocation of emissions across the UK which yields the maximum amount of environmental protection per unit of emission.The paper then goes on to consider the changes that will have to take place within the UK power generation industry in order to meet the revised EC Large Combustion Plant Directive which comes into force on 1 January 2008. Particular emphasis is placed upon proposed emissions trading schemes and the environmental implications of allowing trading between stations with high and low pollution potentials. The paper concludes by suggesting that the emissions trading process should take into account the pollution potential of each source, irrespective of whether the proposed emission is within the plant's agreed emission limit. An approach based entirely on minimizing environmental damage rather than one which takes cost into account, as in current integrated assessment modelling, could provide an interesting approach across the rest of Europe.