Genetic syndromes associated with isolated fetal growth restriction

Early onset fetal growth restriction (FGR) may be due to impaired placentation, environmental or toxic exposure, congenital infections or genetic abnormalities. Remarkable research, mainly based on retrospective series, has been published on the diverse genetic causes. Those have become more and more relevant with the improvement in the accuracy of the analysis techniques and the rising of breakthrough genomewide methods such as the whole genome sequencing. However, no publication has presented an integrated view of management of those fetuses with an early and severe affection. In this review, we explored to which extent genetic syndromes can cause FGR fetuses without structural defects. The most common chromosomal abnormalities (Triploidies and Trisomy 18), submicroscopic chromosomal anomalies (22q11.2 microduplication syndrome) and single gene disorders (often associated with mild ultrasound findings) related to early and severe FGR had been analysed. Finally, we addressed the impact of epigenetic marks on fetal growth, a matter of growing importance. At the end of this review, we should be able to provide an adequate counseling to parents in terms of diagnosis, prognosis and management of those pregnancies.     

Occupational Medicine—Its Contribution to Protection and Promotion of Health at Work

This article deals with the special demands on occupational medicine due to the changes of work and of tasks at workplaces. Conclusions for research in occupational medicine are drawn from these processes. They are discussed on the basis on an analysis of literature from the years 1980–1998. Focus of future research in the field of occupational medicine is developed by taking international tendencies, the interdisciplinary setting of occupational medicine, and the close relations between science and practice into consideration.     

Observed half-lives of 3H, 90Sr and 137Cs in hydrosphere in the Vltava River basin (Bohemia)

A near field study was set up to follow the effects of the Temelin nuclear power plant construction. Reference levels of artificial radionuclides were monitored in the Vltava River upper course and its tributaries in the period 1990-2001. Monitoring continued even after the waste water release startup during the pilot operation in 2002. The assessment of the (90)Sr and (137)Cs concentrations histories in ground water, river bottom sediments and fish showed a decreasing trend. This trend was not influenced by the nuclear power plant pilot operation. In the case of tritium, trend of increasing concentration had been already observed since the pilot operation startup. The monitoring of changes in concentrations of artificial and natural radionuclides in influenced and uninfluenced profiles will be maintained to assess the possible influence of the operation of the Temelin nuclear power plant.     

Noise annoyance responses of middle school pupils and teachers

The present survey study had three aims: (1) to compare pupils’ and teachers’ annoyance responses to classroom noise, (2) to compare females and males responses and (3) to test annoyance models that fitted both pupils and teachers. The study included 207 pupils, aged 13–14 years, and 166 teachers, aged 21–65 years. Both pupils and teachers rated chatter as the most disturbing noise source in the classroom. In line with predictions, the teachers experienced themselves as more sensitive to noise, had poorer hearing status, and reported more intense stress symptoms than the pupils. Contrary to expectations, the teachers were more annoyed and they perceived the noise to be more unpredictable than the pupils did. The control items showed a mixed pattern. There were no overall differences between females and males annoyance responses, but females reported having more stress symptoms than males. A conceptual model was tested with structural equation models, where noise sensitivity mediated the relationship between hearing status and annoyance, which in turn affected stress symptoms. Control and predictability were tested as moderators of the relations between stress symptoms and annoyance. The data fit the conceptual model reasonable well when both samples were included in the same test.     

浮游植物和水质表征:从瑞典梅拉伦、哈马伦、韦特恩和维纳恩湖等大湖泊中获得的经验

自20世纪60年代以来,瑞典梅拉伦湖、哈马伦湖、韦特恩湖和维纳恩湖等大湖泊的浮游植物和环境变量一直处于监测之下.20世纪70年代政府出台了一些减少磷和工业废品排放的措施,于是水体磷的含量降低了90%～95%,结果大多数污染湖盆磷的浓度减少了一半.体现在浮游植物群落的变化是夏季蓝藻细菌、春季硅藻和隐鞭毛藻的生物量迅速降低,另一个反应是藻华期变短,生长季节的物种丰富度和生物量均匀度增加,浮游植物群落内物种数量和组成发生变化.此外,大湖泊物种丰富度相应与湖泊的特征有关.本文对湖泊中有毒蓝藻细菌的发生作了介绍,结合哈马伦湖和梅拉伦湖的藻华,确定在13～0.1 μg/L之间的微藻素最大和最小值;给出利用浮游植物作为监测指标确定水质量变化的基本框架,并提出了评价标准.     

Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure

In the context of a prospective study on the adverse effects of anti-epileptic drugs on fetal outcome, we evaluated our experience with prenatal diagnosis by ultrasonography and α- fetoprotein (AFP) determination in amniotic fluid. We compared these results with AFP values in maternal serum obtained prior to amniocentesis. From November 1985 to July 1990, amniocentesis at 16–18 weeks of gestation was performed in 267 pregnancies of 237 different women using anti-epileptic drugs. Among 92 pregnancies with maternal valproic acid use, five (including one concordantly affected monozygotic twin-pair) were terminated because of a spina bifida aperta, all prenatally diagnosed by AFP determination and acetylcholinesterase electrophoresis in amniotic fluid. The maternal serum AFP level was raised (⩾ 2.5 multiples of the median (MOM) for singleton pregnancies and ⩾ 4.5 MOM for twin pregnancies) in only two of these five affected pregnancies. We emphasize that maternal serum AFP levels may be unreliable for prenatal screening for fetal neural tube defects in women taking valproate and recommend that amniocentesis and fetal ultrasound examination should be offered directly.