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91.
John P. Giesy John W. Bowling Henry J. Kania Robert L. Knight Susan Mashburn 《Environment international》1981,5(3):159-175
Five 10 μg Cd·l?1 were continuously input to aquatic microcosm channels for one year. Cadmium accumulation in both biotic and abiotic components was determined. Cadmium inputs and outputs equilibrated within approximately 20 days of initial Cd inputs. Most community components accumulated Cd proportional to Cd water concentrations. Equilibrium Cd concentrations of sediments, aufwuchs, macrophytes, chironomids, and mosquito fish exposed to 10 μg Cd·l?1 were 0.59, 55, 250, 40, and 40 μg Cd·g?1, dry weight, respectively. Cadmium was rapidly eliminated from all biotic components when Cd inputs were terminated. Cadmium concentrations were similar to those in control channels within a few weeks in the aufwuchs community to a few months in macrophytes after Cd inputs were terminated. Cadmium uptake fluxes by the aufwuchs community and mosquito fish were first order, with respect to Cd concentration in the water. The rate constants for uptake and depuration for the aufwuchs community were 0.42 and 0.66 d?1, respectively (concentration basis). The rate constants for uptake and depuration of Cd by mosquitofish were approximately 25 and 0.004 d?1, respectively (concentration basis). Cadmium concentrations in organic headpool sediments had not significantly decreased six months after cessation of Cd inputs, which indicates that the abiotic half time for contaminated organic sediments is very long. Half times for elimination from channel sand sediments were 72 and 38 d for 5 and 10 μg·l?1 exposure, respectively, after Cd inputs were terminated Cd concentrations in macroinvertebrates varied seasonally. The carrying capacity of the channels microcosm limited the number of samples of secondary and tertiary consumers which could be sampled. It was concluded that concluded that experimental channels of the size described here were not appropriate as screening tools for the fates of trace contaminants, but were effective for the study of trace contaminants, especially in conjunction with mathematical modeling efforts and less complex laboratory studies. 相似文献
92.
93.
Kurunthachalam Kannan Simonetta Corsoline Takashi Imagaws Silvano Focardi John P.Giesy 《Ambio-人类环境杂志》2002,31(3):207-211
我们曾对从意大利收集的金枪鱼、箭鱼、普通鸬鹚以及家燕体内的p,p'-DDE、多氯联苯同类物(PCBs)、多氯二苯-p-二恶英(PCDDs)、多氯二苯并呋喃(PCDFs)以及多氯萘(PCNs)浓度进行过测量. 相似文献
94.
Bioconcentration of p-nonylphenol (NP) by fathead minnows was determined under laboratory conditions. Fish were exposed continuously for 42 days to 0.33, 0.93 and 2.36 μgNP/l in a flow-through system. NP was Soxhlet extracted from whole fish homogenates with dichloromethane (DCM). The resulting extract was concentrated and bulk lipids removed by gel permeation and silica-gel chromatography. Compounds were identified and quantified by reverse-phase high-pressure liquid chromatography (RP-HPLC) with fluorescence detection. Mass spectrometry was used for verification of peak assignments. Bioconcentration factors (BCFs) ranged from 245 to 380. 相似文献
95.
Hecker Markus Hollert Henner Cooper Ralph Vinggaard Anne-Marie Akahori Yumi Murphy Margaret Nellemann Christine Higley Eric Newsted John Wu Rudolph Lam Paul Laskey John Buckalew Angela Grund Stefanie Nakai Makoto Timm Gary Giesy John 《Environmental science and pollution research international》2007,14(1):23-30
Background, Goals and Scope In response to concerns that have been raised about chemical substances that may alter the function of endocrine systems and
result in adverse effects on human health, an OECD initiative was undertaken to develop and validate in vitro and in vivo assays to identify chemicals that may interfere with endocrine systems of vertebrates. Here we report on studies that were
conducted to develop and standardize a cell-based screening assay using the H295R cell line to prioritize chemicals that may
act on steroidogenic processes in humans and wildlife. These studies are currently ongoing as part of the ‘Special Activity
on the Testing and Assessment of Endocrine Disruptors’ within the OECD Test Guidelines Program to review, develop, standardize,
and validate a number of in vitro and in vivo toxicological assays for testing and assessment of chemicals concerning their potential to interact with the endocrine system
of vertebrates.
Study Design Six laboratories from five countries participated in the pre-validation studies. Each laboratory tested the effects of three
model chemicals on the production of testosterone (T) and estradiol (E2) using the H295R Steroidogenesis Assay. Chemicals
tested were well described inducers or inhibitors of steroidogenic pathways (forskolin, prochloraz and fadrozole). All experiments
were conducted in 24 well plates following standard protocols. Six different doses per compound were analyzed in triplicate
per plate. A quality control (QC) plate was run in conjunction with the chemical exposure plate to account for inter-assay
variation. Each chemical exposure was conducted two or three times.
Results All laboratories successfully detected increases and/or decreases in hormone production by H295R cells after exposure to the
different model compounds and there was good agreement in the pattern of response for all groups. Forskolin increased both
T and E2 while fadrozole and prochloraz decreased production of both hormones. All chemicals affected hormone production in
a dose-dependent manner with the exception of fadrozole which caused maximum inhibition of E2 at the two least concentrations
tested. Some inter-laboratory differences were noted in the alteration of hormone production measured in chemically exposed
cells. However, with the exception of the production of T measured at one laboratory in cells exposed to forskolin, the EC50s calculated were comparable (coefficients of variation 34–49%) for all hormones.
Discussion and Perspectives The results indicated that the H295R Steroidogenesis Assay protocol was robust, transferable and reproducible among all laboratories.
However, in several instances that were primarily related to one laboratory there were unexplained minor uncertainties related
to the inter-laboratory hormone production variation. Based on the findings from this Phase 2 prevalidation study, the H295R
Steroidogenesis Assay protocol is currently being refined. The next phase of the OECD validation program will test the refined
protocol among the same group of laboratories using an extended set of chemicals (∼30) that will include positive and negative
chemical controls as well as a broad spectrum of different potential inducers and inhibitors of steroidogenic pathways.
Submission Editor: Dr. Carsten Brühl (bruehl@uni-landau.de) 相似文献
96.
97.
Livers of birds collected from Japan and Korea (n = 83) were analyzed to determine the concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanesulfonamide (FOSA), perfluorooctanoic acid (PFOA) and perfluorohexanesulfonate (PFHS). PFOS was found in the livers of 95% of the birds analyzed at concentrations greater than the limit of quantitation (LOQ) of 10 ng/g, wet weight. The greatest concentration of PFOS of 650 ng/g, wet weight, was found in the liver of a common cormorant from the Sagami River in Kanagawa Prefecture. Concentrations of PFOS in bird livers from Japan and Korea were within the ranges of values reported for those from the United States and certain European countries. PFOA and PFHS were found in 5-10% of the samples analyzed. The greatest concentrations of PFOA and PFHS in bird livers were 21 and 34 ng/g, wet weight, respectively. FOSA was found in all the samples (n = 10) of cormorants collected from the Sagami River in Japan. The greatest concentration of FOSA in cormorant liver was 215 ng/g, wet weight. There was no significant correlation between the concentrations of PFOS and FOSA in cormorants collected from the Sagami River. These results suggested that the distribution of FOSA is localized. No age- or gender-specific differences in fluorochemical concentrations could be discerned in birds. 相似文献
98.
Villalobos SA Papoulias DM Pastva SD Blankenship AL Meadows J Tillitt DE Giesy JP 《Chemosphere》2003,53(8):819-826
The toxicity of o,p'-DDE (1,1-dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethylene) was evaluated in embryos of medaka (Oryzias latipes) following a one time exposure via nanoinjection. Medaka eggs (early gastrula) were injected with 0.5 nl of triolein (vehicle control) or 0.5 nl of 4 graded doses (0.0005-0.5 ng/egg) of o,p'-DDE in triolein. Embryos were allowed to develop, and fry were reared. Embryonic survival was monitored daily during the first 10 d until hatching and thereafter, on a weekly basis until day 59, at which time the fish were monitored for sexual maturity until day 107. In general, o,p'-DDE caused a dose- and time-dependent mortality. No changes in mortality were observed between the last two time points (day 38 and 59, respectively), and hence a 59 day-LD50 of 346 ng o,p'-DDE/egg was derived from the linear dose-response relationship. Prior to late stage death, only isolated cases of cardiovascular lesions and spinal deformities were observed, but were not dose-dependent. The lowest observable adverse effect level (LOAEL), based on upper 95% CI for regression line=0.0018 mg/kg, and the LOAEL based on exposure doses=0.5 mg/kg. Likewise, the no observable adverse effect level (NOAEL) based on linear extrapolation to 100% survival=0.0000388 mg/kg, while the NOAEL based on exposure doses=0.05 mg/kg. The nanoinjection medaka model has potential in the study of hormonally active compounds in the environment. 相似文献
99.
William W. Bowerman David A. Best Teryl G. Grubb Gregory M. Zimmerman John P. Giesy 《Environmental monitoring and assessment》1998,53(1):197-212
Bald eagle (Haliaeetus leucocephalus) numbers in North America have increased since the ban of DDT and other organochlorine compounds in the 1970s. The decrease in the environmental concentrations of p,p-DDE has lead to the lessening of egg-shell thinning and has been a major reason for the current resurgence of bald eagle populations in temperate North America, however, this recovery has not been uniform. Eagles nesting along the shorelines and islands of the Great Lakes have continued to experience impaired productivity. In order to examine some of the reasons for the current recovery of bald eagles in the Great Lakes Basin and the potential use of eagles as a bioindicator species of Great Lakes water quality, we analyzed trends in reproductive activity, concentrations of PCBs and p,p-DDE in unhatched eggs, and rates of developmental deformities. Numbers of occupied nests, fledged young, and yearly productivity rates have increased across the basin. No trends have been observed in changes in the concentrations of p,p-DDE nor Total PCBs in unhatched eggs. An increasing rate in the incidence of developmental deformities in nestlings has been observed in Michigan. The recovery of the bald eagle population along the Great Lakes is most likely due to immigration of relatively uncontaminated adults from Interior regions. 相似文献
100.
Fanhao Song Fengchang Wu Weiying Feng Zhi Tang John P. Giesy Fei Guo Di Shi Xiaofei Liu Ning Qin Baoshan Xing Yingchen Bai 《环境科学学报(英文版)》2018,30(12):116-125
Structural characteristics and proton binding properties of sub-fractions (FA3–FA13) of fulvic acid (FA), eluted stepwise by pyrophosphate buffer were examined by use of fluorescence titration combined with fluorescence regional integration (FRI) and differential fluorescence spectroscopy (DFS). Humic-like (H-L) and fulvic-like (F-L) materials, which accounted for more than 80% of fluorescence response, were dominant in five sub-fractions of FA. Based on FRI analysis, except the response of F-L materials in FA9 and FA13, maximum changes in percent fluorescence response were less than 10% as pH was increased from 2.5 to 11.5. Contents of carboxylic and phenolic groups were compared for fluorescence peaks of FA sub-fractions based on pH-dependent fluorescence derived from DFS. Static quenching was the dominant mechanism for binding of protons by FA sub-fractions. Dissociation constants (pKa) were calculated by use of results of DFS and the modified Stern-Volmer relationship. The pKa of H-L, F-L, tryptophan-like and tyrosine-like materials of FA sub-fractions exhibited ranges of 3.17–4.06, 3.12–3.97, 4.14–4.45 and 4.25–4.76, respectively, for acidic pHs. At basic pHs, values of pKa for corresponding materials were in ranges of 9.71–10.24, 9.62–10.99, 9.67–10.31 and 9.33–10.28, respectively. At acidic pH, protein-like (P-L) materials had greater affinities for protons than did either H-L or F-L materials. The di-carboxylic and phenolic groups were likely predominant sites of protonation for both H-L and F-L materials at both acidic and basic pHs. Amino acid groups were significant factors during proton binding to protein-like materials of FA sub-fractions at basic pH. 相似文献