The fatality consequences of the 65 mph speed limits, 1989

This study examined whether the number of fatalities on rural interstates in 1989 was higher than would be expected based on experience during 1982–1986 and experience on all other roads. Among the 40 states that increased the speed limit to 65 mph on rural interstates, the number of fatalities was 29% higher than expected. Among the eight states retaining a 55 mph maximum speed limit on rural interstates, the observed number of fatalities was 12% lower than expected, although this reduction was not statistically significant. After adjusting the fatality risk on rural interstates for differences in vehicle miles traveled on those roads and for higher passenger vehicle occupancy rates attributable to possible increases in vacation travel, the increased fatality risk was 19%. These data suggest that the majority of the estimated increase in fatalities on rural interstates in 1989 (almost 400 of the approximately 600 extra deaths) can be attributed to the higher speeds resulting from the higher speed limits. Changes in mileage account for the remaining 200 extra deaths.     

Leadership styles and group organizational citizenship behavior across cultures

This study investigates (a) the effects of societal culture on group organizational citizenship behavior (GOCB), and (b) the moderating role of culture on the relationship between directive and supportive leadership and GOCB. Data were collected from 20 336 managers and 95 893 corresponding team members in 33 countries. Multi‐level analysis was used to test the hypotheses, and culture was operationalized using two dimensions of Hofstede ( 2001 ) and GLOBE (2004): Individualism (IDV) and power distance (PD). There was no direct relationship between these cultural dimensions and GOCB. Directive leadership had a negative relation, and supportive leadership a positive relation with GOCB. Culture moderated this relationship: Directive leadership was more negatively, and supportive behavior less positively, related to GOCB in individualistic compared to collectivistic societies. The moderating effects of societal PD were explained by societal IDV. Copyright © 2007 John Wiley & Sons, Ltd.     

Multicenter clinical experience with non-invasive cell-free DNA screening for monosomy X and related X-chromosome variants

Objective

We aimed to investigate how the presence of fetal anomalies and different X chromosome variants influences Cell-free DNA (cfDNA) screening results for monosomy X.

Methods

From a multicenter retrospective survey on 673 pregnancies with prenatally suspected or confirmed Turner syndrome, we analyzed the subgroup for which prenatal cfDNA screening and karyotype results were available. A cfDNA screening result was defined as true positive (TP) when confirmatory testing showed 45,X or an X-chromosome variant.

Results

We had cfDNA results, karyotype, and phenotype data for 55 pregnancies. cfDNA results were high risk for monosomy X in 48/55, of which 23 were TP and 25 were false positive (FP). 32/48 high-risk cfDNA cases did not show fetal anomalies. Of these, 7 were TP. All were X-chromosome variants. All 16 fetuses with high-risk cfDNA result and ultrasound anomalies were TP. Of fetuses with abnormalities, those with 45,X more often had fetal hydrops/cystic hygroma, whereas those with “variant” karyotypes had different anomalies.

Conclusion

Both, 45,X or X-chromosome variants can be detected after a high-risk cfDNA result for monosomy X. When there are fetal anomalies, the result is more likely a TP. In the absence of fetal anomalies, it is most often an FP or X-chromosome variant.