Phase relations between a circadian rhythm and its zeitgeber within the range of entrainment

The regular day-night changes in tissues, physiologic functions, and behavior of organisms are based on endogenous rhythmic processes which under constant conditions continue with periods slightly deviating from 24h. These ‘arcadian’ rhythms have properties of self-sustained oscillators. Under natural conditions, circadian rhythms are synchronized (entrained) to 24 h by periodic factors in the environment, the so-called ‘Zeitgebers’. In the laboratory, circadian rhythms can also be entrained to periods other than 24 h within certain limits. Data on the phase relationship between the circadian rhythm and an entraining light-dark cycle for vertebrates, insects, plants, and unicellular organisms are reviewed.     

Some epidemiologic features of disasters in guatemala

Epidemiological procedures can be organised under disaster conditions by means of a simple surveillance system and with few personnel.
In the aftermath of the 4 February 1976 earthquake in Guatemala, an information system was organized by which the requisite information for decision-making was obtained with adequate speed and promptness.
The initial epidemiologic informution was based on reports collected during the early days on symptoms observed at hospitals and health centers and in localities and villages in the stricken area.
At a second, post-emergency stage a more elaborate surveillance system was instituted to provide guidance in the investigntwn of outbreaks, evaluate the health activities and establish basic criteria for preventive and control measures.     

Traceability,quality assurance,and standards

The development of traceability in low-level radioactivity measurements is discussed. The role that the development of large quantities of natural matrix standards can play is also discussed.     

Threshold and dose response estimation using the “filter model”

The “filter model” has been developed to explain the biologic effects of radiation and chemicals. We have examined nearly 300 sets of dose response data, of which 50 are presented here. Responses (induced by radiation and chemicals) which have been examined include in vitro survival studies on animal and plant tissues, induction of cellular aberrations and time to tumor or death. Similar data from in vivo studies has also been examined. All of the data appear to fit the model R = a lnD + b(lnD)² + c, where R is the response, a and b are parameters fitted by regression to a particular set of data, and c is the response at zero (or lowest) dose. By writing this model in exponential form, it can be seen that the response R results from multistage filtering (by net amounts a and b) of the initial dose, D. The threshold is obtained from this model as the point, $\text{D}\text{?}{}_{\mathrm{T}}$, at which the second derivative becomes zero. This is given by $\text{D}\text{?}{}_{\mathrm{T}}\text{=}\text{exp}\text{(1 ?}\text{a}\text{2b}\text{)}$ when a and b are oppositelt signed.