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41.
Sophie Plumejeaud Amelia Paula Reis Virginie Tassistro Carla Patinha Yves Noack Thierry Orsière 《Environmental geochemistry and health》2018,40(1):127-144
Due to their behavioral characteristics, young children are vulnerable to the ingestion of indoor dust, often contaminated with chemicals that are potentially harmful. Exposure to potentially harmful elements (PHEs) is currently exacerbated by their widespread use in several industrial, agricultural, domestic and technological applications. PHEs cause adverse health effects on immune and nervous systems and can lead to cancer development via genotoxic mechanisms. The present study is an integrated approach that aims at assessing the genotoxicity of bioaccessible PHEs following ingestion of contaminated house dust. A multidisciplinary methodology associating chemical characterization of five house dust samples, extraction of the bioaccessible PHEs in gastric extracts by the unified BARGE method, determination of the bioaccessible fraction and in vitro genotoxicity of gastric extracts in adenocarcinoma gastric human (AGS) cells was developed. The five gastric extracts induced dose-dependent genotoxicity in AGS cells. Copper (bioaccessible concentration up to 111 mg/kg) was probably the prevalent PHE inducing primary DNA damage (up to 5.1-fold increase in tail DNA at 0.53 g/l of gastric extract). Lead (bioaccessible concentration up to 245 mg/kg) was the most prevalent PHE inducing chromosome-damaging effects (r = 0.55; p < 0.001 for micronucleated cells induction). The association of principal component analysis and Spearman’s correlations was decisive to understand the chromosome-damaging properties of the bioaccessible PHEs in AGS cells. This methodology could be used on a larger-scale study to provide useful information for science-based decision-making in regulatory policies, and a better estimation of human exposure and associated health risks. 相似文献
42.
ABSTRACTThis article examines the provision of public parks in Latino and non-Latino neighbourhoods in the Phoenix Metropolitan Area. Though previous research has examined the socio-spatial distribution of urban parks, few have analysed both accessibility and variations in park features associated with the Latino composition of neighbourhoods. In this study, geographical information systems were employed to assess the availability and accessibility of neighbourhood parks, and Google Earth was used to audit their natural and built environmental features. Analysis of variance (ANOVA) with Games-Howell post hoc test was applied to examine the hypothesis that park resources are not equitably distributed across neighbourhoods, and that Latino places are disproportionally affected by a suboptimal provision of park space and services. The analysis points to invariance across neighbourhoods in terms of quantity and features of public parks, so the expected systemic pattern of inequality affecting Latino neighbourhoods in Phoenix Metro was not found. The study suggests, however, some areas wherein cities in the Phoenix Metropolitan Area could act to improve the allocation of public park resources and engage the diversity of local populations. 相似文献
43.
Brooke A. Williams James E.M. Watson Hawthorne L. Beyer Carissa J. Klein Jamie Montgomery Rebecca K. Runting Leslie A. Roberson Benjamin S. Halpern Hedley S. Grantham Caitlin D. Kuempel Melanie Frazier Oscar Venter Amelia Wenger 《Conservation biology》2022,36(4):e13874
Management of the land–sea interface is essential for global conservation and sustainability objectives because coastal regions maintain natural processes that support biodiversity and the livelihood of billions of people. However, assessments of coastal regions have focused strictly on either the terrestrial or marine realm. Consequently, understanding of the overall state of Earth's coastal regions is poor. We integrated the terrestrial human footprint and marine cumulative human impact maps in a global assessment of the anthropogenic pressures affecting coastal regions. Of coastal regions globally, 15.5% had low anthropogenic pressure, mostly in Canada, Russia, and Greenland. Conversely, 47.9% of coastal regions were heavily affected by humanity, and in most countries (84.1%) >50% of their coastal regions were degraded. Nearly half (43.3%) of protected areas across coastal regions were exposed to high human pressures. To meet global sustainability objectives, all nations must undertake greater actions to preserve and restore the coastal regions within their borders. 相似文献