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11.
Sinan Ince Ismail Kucukkurt Hasan Huseyin Demirel Ruhi Turkmen Fahriye Zemheri Erten Akbel 《毒物与环境化学》2013,95(2):318-329
The aim of the present study was to evaluate the possible protective effects of thymoquinone (TQ), an antioxidant agent, against imidacloprid (IMI)-induced oxidative stress in male and female mice. In total, 48 Swiss Albino male and female mice were fed a standard rodent diet and divided into 3 equal groups: the animals in the control group (vehicle treated) were given corn oil, the second group were orally administered 15 mg/kg/day IMI alone, and the third group were orally administered 15 mg/kg/day IMI and with TQ at 10 mg/kg/day for 21 days. During the experimental period, there were no significant changes between initial body weights and final body weights of IMI treated male and female mice. IMI produced significant increase in blood, liver, kidney, and heart malondialdehyde (MDA) levels and decrease in blood and liver glutathione (GSH) levels. In addition, IMI treatment decreased erythrocyte, liver, and kidney superoxide dismutase (SOD) activity in male mice and decreased erythrocyte and liver SOD activity in female mice. Erythrocyte catalase (CAT) activities were found to be low in male and female mice. However, treatment with TQ reversed IMI-induced oxidative stress, lipid peroxidation, and activities of antioxidant enzymes. Moreover, TQ exhibited protective action against the IMI-induced histopathological changes in tissues of male and female mice. In conclusion, TQ was found to be effective in protecting mice against IMI-induced oxidative stress by enhancing antioxidant defense mechanisms. 相似文献
12.
A simple, sensitive, accurate, and selective method for determination of ultratrace levels of Co is modified. The method is
based on preconcentration of Co on the PAR-loaded Amberlite XAD-7 at pH 2.0 ± 0.2 for contact time as low as 45 min. The adsorbed
cobalt was eluted with concentrated nitric acid and measured by flame atomic absorption spectrometry. Recoveries up to 90%
were achieved. The optimized preconcentration method was applied to cobalt determination in natural mineral waters. The detection
limit was found to be 0.1 ng mL−1. The relative standard deviation was found to be 13% for 600 mL of 2.0 ng mL−1, for 10 replicate preconcentration procedures. Cobalt concentrations in the studied water samples were found to be in the
ranges of 0.5–3.5 ng mL−1. 相似文献