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排序方式: 共有194条查询结果,搜索用时 31 毫秒
131.
132.
Martin B. Delatycki Fowzan Alkuraya Alison Archibald Carlo Castellani Martina Cornel Wayne W. Grody Lidewij Henneman Adonis S. Ioannides Edwin Kirk Nigel Laing Anneke Lucassen John Massie Juliette Schuurmans Meow-Keong Thong Irene van Langen Joël Zlotogora 《黑龙江环境通报》2020,40(3):301-310
Reproductive carrier screening started in some countries in the 1970s for hemoglobinopathies and Tay-Sachs disease. Cystic fibrosis carrier screening became possible in the late 1980s and with technical advances, screening of an ever increasing number of genes has become possible. The goal of carrier screening is to inform people about their risk of having children with autosomal recessive and X-linked recessive disorders, to allow for informed decision making about reproductive options. The consequence may be a decrease in the birth prevalence of these conditions, which has occurred in several countries for some conditions. Different programs target different groups (high school, premarital, couples before conception, couples attending fertility clinics, and pregnant women) as does the governance structure (public health initiative and user pays). Ancestry-based offers of screening are being replaced by expanded carrier screening panels with multiple genes that is independent of ancestry. This review describes screening in Australia, Cyprus, Israel, Italy, Malaysia, the Netherlands, Saudi Arabia, the United Kingdom, and the United States. It provides an insight into the enormous variability in how reproductive carrier screening is offered across the globe. This largely relates to geographical variation in carrier frequencies of genetic conditions and local health care, financial, cultural, and religious factors. 相似文献
133.
Irene Scheunert Peter Schröder 《Environmental science and pollution research international》1998,5(4):238-244
The amount of non-extractable residues (NER) of organic xenobiotics in the soil can considerably exceed the amount of extractable residues which are accessible to normal residue analysis. The NER therefore present a burden to the soil, the toxicological and ecotoxicological potential of which is largely unknown. For the characterization of bound residues and their binding type, special solubilization methods such as supercritical fluid extraction are applied and experiments with radiolabeled model polymers are performed. Mineralization experiments with [14C] labeled xenobiotics in natural soil show that a total degradation is still also possible in the environment when in a bound form. Ecotoxicological effects of non-extractable residues may be recorded when their concentration is high, when the parent compound exhibits a high ecotoxicity and the applied detection method is sufficiently sensitive. 相似文献
134.
Zorpas Antonis A. Voukkali Irene Loizia Pantelitsa 《Environmental science and pollution research international》2017,24(16):14304-14311
Environmental Science and Pollution Research - Even though reducing waste is at the top of the waste hierarchy, no real decoupling between waste generation and consumption has been demonstrated.... 相似文献
135.
Béla Bertók Irene Czudor István Székely László Pap László Csíz Péter Forgó 《Journal of environmental science and health. Part. B》2013,48(3):495-513
Abstract Enantiomers and racemic mixtures of selected benzilic esters using resolved and raceme permethrinic or chrysanthemic acids of high purity were synthesised via improved methods based on conventional steps. Nine basic structures of selected derivatives having hydrogen, bromo or phenoxy group at meta position were prepared including the well known insecticides of phenothrin, permethrin and cypermethrin. The optical purity of these compounds were determined via an NMR method applying chiral shift reagents. The configuration of the isomers of new a‐cyano‐benzyl esters were assigned via a rule realized by comparing the characteristic 1H NMR shifts of the dimethyl groups attached to the cyclopropane ring. 相似文献
136.
Costopoulou D Vassiliadou I Papadopoulos A Makropoulos V Leondiadis L 《Chemosphere》2006,65(9):1462-1469
In an attempt to evaluate the background levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho, mono-ortho and indicator polychlorinated biphenyls (PCBs) in people living in an urban (Athens) and a rural (Kozani) area of Greece, blood serum and mother milk samples were analyzed. Analytical results are reported in this study. Statistically significantly differences were observed between regions, sexes and ages. Contamination levels in blood and human milk from Greece reported here are low compared to the previously reported dioxin data from other European countries and give no indication of particular health risk. 相似文献
137.
Camilla Knudsen Tveiten Eirik Albrechtsen Irene Wærø Aud Marit Wahl 《Safety Science》2012,50(10):1960-1966
Emergency management faces a changed reality in terms of possibilities and threats with use of new technology. Due to the ongoing changes in the operation of oil and gas production, different constellations of actors in a distributed system are built. This introduces opportunities for planning and operation. At the same time as new technology offers opportunities, the technology-enabled distributed network of actors generate challenges for emergency handling. The purpose of the study presented has been to look for possibilities for making emergency management more resilient by becoming a part of continuous risk and hazard management. The suggested three main elements that are important to consider in the development of future emergency management are (1) proactive emergency management through early risk anticipation; and emergency management’s adaptation to new and future work practices such as (2) distributed actors and (3) new technology. Based on these results we suggest broadening the scope of emergency management to systematically include monitoring, anticipation, responding and learning. 相似文献
138.
Potential nitrification and denitrification on different surfaces in a constructed treatment wetland
Kallner Bastviken S Eriksson PG Martins I Neto JM Leonardson L Tonderski K 《Journal of environmental quality》2003,32(6):2414-2420
Improved understanding of the importance of different surfaces in supporting attached nitrifying and denitrifying bacteria is essential if we are to optimize the N removal capacity of treatment wetlands. The aim of this study was therefore to examine the nitrifying and denitrifying capacity of different surfaces in a constructed treatment wetland and to assess the relative importance of these surfaces for overall N removal in the wetland. Intact sediment cores, old pine and spruce twigs, shoots of Eurasian watermilfoil (Myriophyllum spicatum L.), and filamentous macro-algae were collected in July and November 1999 in two basins of the wetland system. One of the basins had been constructed on land that contained lots of wood debris, particularly twigs of coniferous trees. Potential nitrification was measured using the isotope-dilution technique, and potential denitrification was determined using the acetylene-inhibition technique in laboratory microcosm incubations. Nitrification rates were highest on the twigs. These rates were three and 100 times higher than in the sediment and on Eurasian watermilfoil, respectively. Potential denitrification rates were highest in the sediment. These rates were three times higher than on the twigs and 40 times higher than on Eurasian watermilfoil. The distribution of denitrifying bacteria was most likely due to the availability of organic material, with higher denitrification rates in the sediment than on surfaces in the water column. Our results indicate that denitrification, and particularly nitrification, in treatment wetlands could be significantly increased by addition of surfaces such as twigs. 相似文献
139.
The synthesis of certain 14C-labelled polychlorinated alkanes is described. The compounds used as starting material were [1-14C]lauric acid, [1-14C]hexadecane and [U-14C]palmitic acid. The carboxylic acids were reduced with lithium aluminium hydride. The alcohol obtained was treated with triphenylphosphine dichloride which gave the corresponding 1-chloroalkane. The chlorination of the alkanes was performed in tetrachloromethane by use of sulphuryl chloride with benzoyl peroxide or UV-light as initiators. Three mixtures of polychlorinated dodecanes (45.9%, 55.9% and 68.5% chlorine) and two polychlorinated hexadecanes (34.1% and 69% chlorine) were synthesized. The products of higher chlorine content prepared were only available via the photoinduced chlorination. 相似文献
140.
Ronald A. Chadderton Irene S. Kropp 《Journal of the American Water Resources Association》1985,21(5):833-839
Evidence suggests that there is no superior wasteload allocation method. Eight allocation strategies have been evaluated based on: total cost of implementation, equity in distributing costs and loads among dischargers, effectiveness in use of available waste assimilative capacity, and sensitivity to changes in water-quality-related variables. One method, which allocated equal percentages of the maximum allowable dissolved oxygen deficit, was eliminated as a feasible strategy because it led to excessive costs and overly conservative load estimates. The other seven methods remained viable alternatives. Two methods proved to be insensitive to changes in the water-quality-related variables tested, which may be advantageous in certain applications. This report presents seven workable alternatives that may be used in wasteload allocation and demonstrates a procedure to determine the practicability of other methods. 相似文献