Sex-specific differences in early renal impairment associated with arsenic,lead, and cadmium exposure among young adults in Taiwan

Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association between exposure to arsenic (As), cadmium (Cd), and lead (Pb), and early renal impairment markers using urinary microalbumin (MA), β2-microglobulin (β2MG), and N-acetyl-beta-D-glucosaminidase (NAG) by analyzing 157 young adults aged 20?29 years, in Taiwan. Inductively coupled plasma mass spectrometry was used to determine urinary As, Cd, and Pb levels. Regression models were applied to different sex groups. The results showed that after adjusting for potential confounding factors and each metal, urinary Cd levels were significantly positively associated with urinary MA (β?=?0.523, 95% CI: 0.147–0.899) and β2MG (β?=?1.502, 95% CI: 0.635–2.370) in males. However, the urinary Cd level was significantly positively associated with only urinary NAG (β?=?0.161, 95% CI: 0.027–0.296) in females. This study thus indicates that the effect of exposure to metals (especially Cd) on early renal impairment among young adults in Taiwan is sex-specific. Our study results could contribute toward developing early intervention programs for decreasing the incidence of renal dysfunction. Further studies are warranted to confirm our findings and clarify the potential mechanisms involved.

     

PLA Based Biopolymer Reinforced with Natural Fibre: A Review

In recent years renewed interest on the development of biopolymers, based on constituents obtained from natural resources is gaining much attention. Natural fibres such as kenaf, hemp, flax, jute, bamboo, elephant grass and sisal based polymer with thermoplastic and thermoset matrices offer reductions in weight, cost and carbon dioxide emission, less reliance on foreign oil resources and recyclability. Reinforced biopolymer with natural fibres is the future of “green composites” addressing many sustainability issues. Among the available biopolymer, PLA (polylactide) is the only natural resource polymer produced at a large scale of over 140,000 tonnes per year. Natural fibre reinforced PLA based biocomposites are widely investigated by the polymer scientists in the last decade to compete with non renewable petroleum based products. The type of fibre used plays an important role in fibre/matrix adhesion and thereby affects the mechanical performance of the biocomposites. The aim of this review is to investigate the effects of processing methods, fibre length, fibre orientation, fibre-volume fraction, and fibre-surface treatment on the fibre/matrix adhesion and mechanical properties of natural-fibre-reinforced PLA composites. Although much work has been performed to engineer the design of such superior biocomposites, the information is scattered in nature. A comprehensive review on the major technical considerations undertaken to prepare such biocomposites over the last decade is investigated to address the feasibility of wide scale industrial acceptance to such biocomposites. A brief review on the available natural fibres and biopolymer is also given for a comparative study.     

Measurement of chlorophyll fluorescence reveals mechanisms for habitat niche separation of the intertidal seagrasses <Emphasis Type="Italic">Thalassia hemprichii</Emphasis> and <Emphasis Type="Italic">Halodule uninervis</Emphasis>

In Taiwan, Thalassia hemprichii dominates the upper intertidal zone, whereas Halodule uninervis occupies the lower intertidal zone. We tested the hypothesis that T. hemprichii is better adapted to high irradiance and more resistant to air exposure than H. uninervis. The photosynthetic efficiency, damage, and extent of recovery were determined by measuring chlorophyll fluorescence using pulse amplitude modulated fluorometry. Both species growing in tidal pools, in response to high irradiance alone, revealed a small depression in maximal quantum yield of photosystem II (Fv/Fm) at noon. The second experiment compared the effect of air exposure alone and the combined effect of air exposure with high irradiance by interposing a shading screen on both species, growing in the intertidal zone over a diurnal cycle. Values of Fv/Fm of both the shaded and irradiated T. hemprichii remained high at low tide. However, H. uninervis exhibited a marked depression following air exposure and a synergistic depression under the combined effect. The experimental manipulations of exposure time demonstrated that the tolerance of T. hemprichii to the combined effect was longer and the recovery from air exposure following re-submersion was better than those of H. uninervis. Both species were more susceptible to the combined effect in the dry season than in the wet season. Our results suggest that air exposure is more important than high irradiance in constraining the distribution of H. uninervis in the upper intertidal zone. This was confirmed by transplantation experiments in which a rapid decline of H. uninervis was observed after transplantation into the upper intertidal zone. In the lower intertidal zone, measurements of the response of the photosynthetic electron transport rate to irradiance demonstrated that the transplanted T. hemprichii exhibited a sun-type response and H. uninervis a shade-type response.     

Development of injury risk models to guide CT evaluation in the emergency department after motor vehicle collisions

Abstract

Objective: The clinical evaluation of motor vehicle collision (MVC) victims is challenging and commonly relies on computed tomography (CT) to detect internal injuries. CT scans are financially expensive and each scan exposes the patient to additional ionizing radiation with an associated, albeit low, risk of cancer. Injury risk prediction based on regression modeling has been to be shown to be successful in estimating Injury Severity Scores (ISSs). The objective of this study was to (1) create risk models for internal injuries of occupants involved in MVCs based on CT body regions (head, neck, chest, abdomen/pelvis, cervical spine, thoracic spine, and lumbar spine) and (2) evaluate the performance of these risk prediction models to predict internal injury.

Methods: All Abbreviated Injury Scale (AIS) 2008 injury codes were classified based on which CT body region would be necessary to scan in order to make the diagnosis. Cases were identified from the NASS-CDS. The NASS-CDS data set was queried for cases of adult occupants who sought medical care and for which key crash characteristics were all present. Forward stepwise logistic regression was performed on data from 2010–2014 to create models predicting risk of internal injury for each CT body region. Injury risk for each region was grouped into 5 levels: very low (<2%), low (2–5%), medium (5–10%), high (10–20%), and very high (20%). The models were then tested using weighted data from 2015 in order to determine whether injury rates fell within the predicted risk level.

Results: The inclusion and exclusion criteria identified 5,477 cases in the NASS-CDS database. Cases from 2010–2014 were used for risk modeling (n?=?4,826). Seven internal injury risk models were created based on the CT body regions using data from 2010–2014. These models were tested against data from 2015 (n?=?651). In all CT body regions, the majority of occupants fell in the very low or low predicted injury rate groups, except for the head. On average, 57% of patients were classified as very low risk and 15% as low risk for each body region. In most cases the actual rate of injury was within the predicted injury risk range. The 95% confidence interval overlapped with predicting injury risk range in all cases.

Conclusion: This study successfully demonstrated the ability for internal injury risk models to accurately identify occupants at low risk for internal injury in individual body regions. This represents a step towards incorporating telemetry data into a clinical tool to guide physicians in the use of CT for the evaluation of MVC victims.     

The development of stream temperature model in a mountainous river of Taiwan

Formosan landlocked salmon is an endangered species and is very sensitive to stream temperature change. This study attempts to improve a former stream temperature model (STM) which was developed for the salmon’s habitat to simulate stream temperature more realistically. Two modules, solar radiation modification (SRM) and surface/subsurface runoff mixing (RM), were incorporated to overcome the limitation of STM designed only for clear-sky conditions. It was found that daily temperature difference is related to cloud cover and can be used to adjust the effects of cloud cover on incident solar radiation to the ground level. The modified model (STM + SRM) improved the simulation during a baseflow period in both winter and summer with the Nash-Sutcliffe efficiency coefficient improved from 0.37 (by STM only) to 0.71 for the winter and from ?0.18 to 0.70 for the summer. On the days with surface/subsurface runoff, the incorporation of the two new modules together (STM + SRM + RM) improved the Nash-Sutcliffe efficiency coefficient from 0.00 to 0.65 and from 0.29 to 0.83 in the winter and the summer, respectively. Meanwhile, the contributions of major thermal sources to stream temperature changes were identified. Groundwater is a major controlling factor for regulating seasonal changes of stream temperature while solar radiation is the primary factor controlling daily stream temperature variations. This study advanced our understanding on short-term stream temperature variation, which could be useful for the authorities to restore the salmon’s habitat.     

A model for the implementation of a two-shift municipal solid waste and recyclable material collection plan that offers greater convenience to residents

Separating recyclables from municipal solid waste (MSW) before collection reduces not only the quantity of MSW that needs to be treated but also the depletion of resources. However, the participation of residents is essential for a successful recycling program, and the level of participation usually depends on the degree of convenience associated with accessing recycling collection points. The residential accessing convenience (RAC) of a collection plan is determined by the proximity of its collection points to all residents and its temporal flexibility in response to resident requirements. The degree of proximity to all residents is determined by using a coverage radius that represents the maximum distance residents need to travel to access a recycling point. The temporal flexibility is assessed by the availability of proximal recycling points at times suitable to the lifestyles of all residents concerned. In Taiwan, the MSW collection is implemented at fixed locations and at fixed times. Residents must deposit their garbage directly into the collection vehicle. To facilitate the assignment of collection vehicles and to encourage residents to thoroughly separate their recyclables, in Taiwan MSW and recyclable materials are usually collected at the same time by different vehicles. A heuristic procedure including an integer programming (IP) model and ant colony optimization (ACO) is explored in this study to determine an efficient two-shift collection plan that takes into account RAC factors. The IP model has been developed to determine convenient collection points in each shift on the basis of proximity, and then the ACO algorithm is applied to determine the most effective routing plan of each shift. With the use of a case study involving a city in Taiwan, this study has demonstrated that collection plans generated using the above procedure are superior to current collection plans on the basis of proximity and total collection distance.     

Control strategies for biohydrogen production by immobilized co-culture of Clostridium butyricum and Rhodopseudomonas palustris

In this study, we evaluated biohydrogen production of Clostridium butyricum and Rhodopseudomonas palustris by immobilized co-culture. Effects of free cells and immobilized cells, immobilized biomass ratio, sucrose concentration, and initial pH on hydrogen production were investigated. The immobilized co-culture can achieve high cumulative hydrogen volume yield (604 mL) as compared to free co-culture cumulative hydrogen volume (513 mL) while the initial sucrose concentration was 17.8 g/L. The optimum C. butyricum/R. palustris ratio was 1:10, yielding the highest cumulative hydrogen (728 mL). High sucrose concentration (above 35.6 g/L) would inhibit hydrogen production. The optimal initial pH value for hydrogen production of immobilized co-culture was 7.0 (cumulative hydrogen volume 830 mL).     

Subregion districting analysis for municipal solid waste collection privatization

Privatization of municipal solid waste (MSW) collection can improve service quality and reduce cost. To reduce the risk of an incapable company serving an entire collection area and to establish a competitive market, a large collection area should be divided into two or more subregions, with each subregion served by a different company. The MSW subregion districting is generally done manually, based on the planner's intuition. Major drawbacks of a manual approach include the creation of a districting plan with poor road network integrity for which it is difficult to design an efficient collection route. The other drawbacks are difficulty in finding the optimal districting plan and the lack of a way to consistently measure the differences among subregions to avoid unfair competition. To determine an MSW collection subregion districting plan, this study presents a mixed-integer optimization model that incorporates factors such as compactness, road network integrity, collection cost, and regional proximity. Two cases are presented to demonstrate the applicability of the proposed model. In both cases, districting plans with good road network integrity and regional proximity have been generated successfully.     

Application of Klebsiella oxytoca immobilized cells on the treatment of cyanide wastewater

Klebsiella oxytoca, isolated from cyanide-containing industrial wastewater, has been shown to be able to biodegrade cyanide to non-toxic end products. The technology of immobilized cells can be applied in biological treatment to enhance the efficiency and effectiveness of biodegradation. In this study, potassium cyanide was used as the target compound and both alginate and cellulose triacetate techniques were applied for the preparation of immobilized cells. Results from this study show that KCN can be utilized as the sole nitrogen source by K. oxytoca. The free suspension systems reveal that the cell viability was highly affected by initial KCN concentration and pH. Results show that immobilized cell systems could tolerate a higher level of KCN concentration and wider ranges of pH. In the batch experiments, the maximum KCN removal efficiencies using alginate and cellulose triacetate immobilized beads were 0.108 and 0.101mM h(-1) at pH 7, respectively. Results also indicate that immobilized system can support a higher biomass concentration. Complete KCN degradation was observed after the operation of four consecutive degradation experiments with the same batch of immobilized cells. This suggests that the activity of immobilized cells can be maintained and KCN can be used as the nitrogen source throughout KCN degradation experiments. The maximum KCN removal rates using alginate and cellulose triacetate immobilized beads in continuous-column system were 0.224 and 0.192mMh(-1) with initial KCN concentration of 3mM, respectively. Results indicate that the immobilized cells of K. oxytoca would be applicable to the treatment of cyanide-containing wastewaters.     

Formation and Removal Reactions of Hazardous Air Pollutants

Current regulatory policies for hazardous air pollutants (HAPs) target the sources of direct emissions. In addition to direct emissions, some of the aromatic, nitrogenated, and oxygenated HAPs can be formed in the atmosphere. Formaldehyde and acetaldehyde, in particular, are produced by almost every hydrocarbon photooxidation reaction. Estimates have been made that, in some urban areas, in situ formation contributes as much as 85 percent of the ambient levels of formaldehyde and 95 percent for acetaldehyde. Over 40 percent of the HAPs being regulated under Title III of the 1990 Clean Air Act Amendments have atmospheric lifetimes of less than one day. The transformation products of these HAPs with low atmospheric persistence are important for assessing risks to human health, especially for cases where the transformation products are more toxic than the HAP itself.