Effect of epibiosis on the fitness of the sandy shore snail<Emphasis Type="Italic"> Batillaria zonalis</Emphasis> in Hong Kong

Batillaria zonalis is a common snail on Hong Kong sandy shores, occupying the low-mid shore. Shells of B. zonalis (basibiont) are often fouled with the rock oyster Saccostrea cucullata and the barnacle Balanus reticulatus (epibiont). This epibiotic interaction has a negative impact on the fitness of B. zonalis in terms of impairing fecundity, mobility and metabolism of fouled individuals. During the reproductive season, fouled snails had lower Gonadosomatic Index and fewer egg-bearing individuals than non-fouled snails. Fouled snails crawled in a more tortuous pathway and with lower speed when compared with non-fouled snails. Reduction in oxygen consumption and metabolic rate in fouled snails further suggested the restriction in mobility of B. zonalis by the epibionts. Glycogen content in the foot muscle tissues and hepatopancreas of fouled and non-fouled snails was, however, similar, revealing epibiosis does not influence the energy storage of B. zonalis. Mortality of fouled and non-fouled snails was similar under laboratory conditions, suggesting epibiosis does not influence the survivorship of B. zonalis in Hong Kong. Impairment in the fitness of fouled B. zonalis indicates that epibiosis can influence the population dynamics of B. zonalis in Hong Kong.Communicated by T. Ikeda, Hakodate     

Some aspects of toxic contaminants in herbal medicines

A World Health Organisation survey indicated that about 70-80% of the world populations rely on non-conventional medicine mainly of herbal sources in their primary healthcare. In recent years, we have witnessed the increasing growth in popularity of over-the-counter (OTC) health foods, nutraceuticals, and medicinal products from plants or other natural sources in developed countries. This indirectly indicates that the public is not satisfied with their orthodox medical (OM) treatment. Such increase in popularity has also brought concerns and fears over the professionalism of practitioners, and quality, efficacy and safety of their treatment methods and products from herbal and natural sources available in the market. Over the past decade several news-catching episodes in developed communities indicated adverse effects, sometimes life threatening, allegedly arisen consequential to taking of OTC herbal products or traditional medicines from various ethnic groups. These OTC products may be contaminated with excessive or banned pesticides, microbial contaminants, heavy metals, chemical toxins, and for adulterated with orthodox drugs. Excessive or banned pesticides, heavy metals and microbial contaminants may be related to the source of these herbal materials, if they are grown under contaminated environment or during collection of these plant materials. Chemical toxins may come from unfavourable or wrong storage conditions or chemical treatment due to storage. The presence of orthodox drugs can be related to unprofessional practice of manufacturers. Some of these environment related factors can be controlled by implementing standard operating procedures (SOP) leading to Good Agricultural Practice (GAP), Good Laboratory Practice (GLP), Good Supply Practice (GSP) and Good Manufacturing Practice (GMP) for producing these medicinal products from herbal or natural sources. The public's belief that herbal and natural products are safer than synthetic medicines can only be ascertained by imposing regulatory standards on these products that should be manufactured using these Good Practices. Using Chinese medicines, as examples, this paper illustrate how advances in chemical and biomedical analysis would help to detect intentional and unintentional toxic contaminants in herbal substances. The paper also summarises how modernization and progress are being carried out to get the best out of Chinese medicines for public healthcare.     

Lymphatic transport of inhaled diesel particles in the lungs of rats and guinea pigs exposed to diluted diesel exhaust

Factors influencing the disposition of the inhaled diesel particles were studied by analyzing the deposition of radioactively labelled diesel particles in the respiratory system, by determining the specific function of alveolar cellular mechanisms in the primary defense against inhaled particles and by identifying the important role of the lymphatic system in the lung clearance of experimental animals exposed to diluted emissions from a diesel engine. Radioactive ¹³¹Barium was used as a tracer of diesel particles and the deposition efficiency was determined to be 15%±6% of the inhaled dose in the Fischer 344 rat strain. The number of cells obtained by bronchial lavage increased significantly after a prolonged exposure to a concentration of 1500 μg/m³ of diesel particles. The increased cell number was more than twofold, contained two distinct cell populations (alveolar macrophages and neutrophils) and represented a reactive mobilization of the defense mechanisms in the organism. Light microscopy studies investigated the role of lymphatic transport of the particulate matter and revealed that the peribrochial and perivascular aggregates of lymphoid tissue contained diesel particles even after short exposure periods at low dose levels. With the increasing burden of particles in the respiratory system, the coloration of hilar and mediastinal lymph nodes continuously changed to gray and finally to dark black, depending upon the dose level and exposure. However, at all exposure levels, most of the diesel particles in the alveoli were phagocytized by an increased alveolar cellular defence and particle-containing macrophages were actively moving towards the mucociliary escalator or towards lymphatic channels leading to peribronchial lymphoid aggregates and bronchial or mediastinal lymph nodes. In the lymph nodes, alveolar macrophages containing diesel particles were found mostly in the afferent subcapsular lymphatic vessels and marginal sinuses. In the later stages, cellular structure disintegrated and large aggregates of particulate matter were dispersed throughout the medullary cords with increasing accumulation towards the hilus. It is concluded that the lymphoid aggregates and lymphatic nodes play an important role in sequestering diesel particles or particle-containing phagocytizing cells and provide a pathway, in addition to the mocociliary clearance for particulate removal from the deep pulmonary region.     

Introduction to and experimental conditions during the first year of the GMR chronic inhalation studies of diesel exhaust

A chronic exposure study was initiated to determine the effects of diesel exhaust on the health of experimental animals. For this purpose, test atmospheres of clean air (control) or freshly diluted diesel exhaust at concentrations of 250, 750, and 1500 μg/m³ were supplied to four 12.6 m³ inhalation chambers which housed rats and guinea pigs. Diesel aerosol size and concentration, as well as chamber temperature and relative humidity, were continually monitored and controlled to maintain the exposure dose levels and an environment of 22±2°C and 50%±20% relative humidity. The concentrations of CO and NO_x were found to be 5.8±1.0 mg/m³ and 7.9±1.0 mg/m³ above ambient in the chamber containing 1500 μg/m³ of particulate. Animals were supplied from the chambers, on a random basis, for both intramural and extramural studies throughout the exposure period. The experiment ran uninterrupted for over twelve months with mean diesel particle mass concentrations within 2% of the target values.     

The environmental awareness of environmental protection bureaucrats in the People's Republic of China

Summary Over 180 environmental protection bureaucrats in the People's Republic of China were individually interviewed to determine their environmental awareness and their attitudes towards the environment. The study indicates that environmental protection bureaucrats in China have conflicting attitudes towards the relationship between man and nature, and between economic growth and environmental protection. However, they show a strong faith in science and technology's ability to solve environmental problems. The perception that too-harsh environmental protection regulations would reduce the growth potential of the economy is so predominant that it poses a serious threat to the environment of the three municipalities under investigation. It is argued that environmental management is a matter of managing human beings. To understand people, it is imperative to gain a thorough understanding of their worldview.Dr Koon-Kwai Wong is an Associate Professor in the Department of Geography and the Geography option co-ordinator on the China Studies course at Hong Kong Baptist University. Dr Hon S. Chan is an Associate Professor in the Department of Public and Social Administration at the City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong.     

表面防护技术对混凝土结构耐久性能的影响

碳化及其导致的钢筋锈蚀是影响钢筋混凝土耐久性的重要因素。比较了混凝土表面浸渗、涂料涂覆及浸渗＋涂覆复合防护3种表面技术,开展了对混凝土防护的研究。通过碳化试验、紫外/冷凝加速气候老化试验以及混凝土内置钢筋电化学测量等检测手段,研究了3种表面防护技术对混凝土保护性能影响。结果表明,采用硅烷浸渗＋水性氟碳涂层的复合浸涂处理,可明显提高钢筋砼结构耐久性。     

Gene modification therapies for hereditary diseases in the fetus

Proof-of-principle disease models have demonstrated the feasibility of an intrauterine gene modification therapy (in utero gene therapy (IUGT)) approach to hereditary diseases as diverse as coagulation disorders, haemoglobinopathies, neurogenetic disorders, congenital metabolic, and pulmonary diseases. Gene addition, which requires the delivery of an integrating or episomal transgene to the target cell nucleus to be transcribed, and gene editing, where the mutation is corrected within the gene of origin, have both been used successfully to increase normal protein production in a bid to reverse or arrest pathology in utero. While most experimental models have employed lentiviral, adenoviral, and adeno-associated viral vectors engineered to efficiently enter target cells, newer models have also demonstrated the applicability of non-viral lipid nanoparticles. Amelioration of pathology is dependent primarily on achieving sustained therapeutic transgene expression, silencing of transgene expression, production of neutralising antibodies, the dilutional effect of the recipient's growth on the mass of transduced cells, and the degree of pre-existing cellular damage. Safety assessment of any IUGT strategy will require long-term postnatal surveillance of both the fetal recipient and the maternal bystander for cell and genome toxicity, oncogenic potential, immune-responsiveness, and germline mutation. In this review, we discuss advances in the field and the push toward clinical translation of IUGT.     

Perceived benefits of applying Pay for Safety Scheme (PFSS) in construction – A factor analysis approach

In recent years, construction safety has been a hot topic in Hong Kong. The Government of the Hong Kong Special Administrative Region (HKSAR) has launched different safety measures to improve the prevailing safety performance of the construction industry. The Pay for Safety Scheme (PFSS) has emerged as one of the major safety initiatives launched within the public sector construction industry since 1996. It aims to encourage the safety awareness by taking the contractor’s pricing for safety-related items out from the consideration of competitive bidding. The objective is to provide a concise review of the prevailing application of PFSS in Hong Kong in general, and to identify and analyse the key benefits of PFSS in construction through an industry-wide empirical questionnaire survey in particular. Altogether, 145 industrial practitioners who have derived extensive hands-on experience with the PFSS construction projects participated in the survey to indicate their levels of agreement to those 14 key benefits identified which were measured and analysed by factor analysis. The results of factor analysis indicated that the 14 individual benefits of implementing PFSS were consolidated under four underlying factors: (1) Enhancing safety climate and attitude; (2) Promoting effective safety-related communication; (3) Streamlining the safety procedures; and (4) Ensuring adequate safety training. A wider application of PFSS should be encouraged with a view to achieving better safety performance within the industry. It is recommended that a similar scheme to PFSS currently applied in Hong Kong may be developed for implementation in other regions or countries for international comparisons.     

The Janus face of paternalistic leaders: Authoritarianism,benevolence, subordinates' organization‐based self‐esteem,and performance

We investigated how the two components of paternalistic leadership, namely authoritarianism and benevolence, jointly influenced work performance through their impacts on organization‐based self‐esteem (OBSE). Using a sample of 686 supervisor–subordinate dyads collected from a manufacturing firm in the People's Republic of China, we found that OBSE mediated the negative relationship between authoritarian leadership on one hand and subordinate task performance and organizational citizenship behavior toward the organization (OCBO) on the other. We also found that the negative effect of authoritarian leadership on subordinate OBSE, task performance, and OCBO was weaker when supervisors exhibited higher levels of leader benevolence. Also, OBSE mediated the joint effect of authoritarian leadership and benevolent leadership on subordinate task performance and OCBO. Copyright © 2012 John Wiley & Sons, Ltd.     

城市韧性与科技创新耦合协调发展研究——以成渝地区双城经济圈为例

以成渝地区双城经济圈为空间载体,运用熵值法、重心模型和修正耦合协调度模型等方法,分析了2005—2019年成渝地区双城经济圈城市韧性与科技创新的发展水平、重心变动特征及耦合协调发展水平。结果表明:①城市韧性和科技创新的发展水平均呈稳步提升态势,但整体发展水平较低。②城市韧性与科技创新的重心经历了复杂的迁移过程,且二者重心的空间叠置性显著上升,迁移方向基本趋于一致,空间耦合趋势明显。③城市韧性与科技创新的耦合协调水平稳步提升,但整体仍处于失调阶段,总体呈“成都、重庆双核高,周边低”的空间分布格局,且科技创新滞后现象日益突出。