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81.
82.
In 40 pregnancies at risk for the Hurler syndrome 13 affected fetuses were detected by the demonstration of an α-L -iduronidase deficiency and an increased level of 35S-sulphate incorporation. The diagnoses were confirmed by the analysis of fetal tissues and/or cultured fetal skin fibroblasts. Microassays for α-L -iduronidase, using phenyl α-L -iduronide and more recently 4–methyl-umbelliferyl α-L -iduronide, enabled a reliable diagnosis to be made within 15 to 18 days after amniocentesis. 35S-sulphate incorporation has been a valuable adjunct in cases with a low (heterozygote) enzyme activity. 相似文献
83.
The discussion on the possible increase of solar UV on earth due to the destruction of the stratospheric ozone has led to a renewed interest in the action of ultraviolet radiation on biological systems. The paper deals with changes at the cellular level stressing particularly molecular alterations in deoxyribonucleic acid, the carrier of genetic information. The most important repair processes by which lesions are removed or bypassed are described. It is also discussed whether the effectivity of a complex spectrum can be predicted on the basis of measurements with monochromatic radiation. Furthermore, possible consequences on human health are outlined which may be derived from cellular studies. 相似文献
84.
P. A. Hurley Mr R. H. T. Ward B. Teisner R. K. Iles M. Lucas J. G. Grudzinskas 《黑龙江环境通报》1993,13(10):903-908
Serum PAPP-A measurements taken from 254 women in the first trimester are reported. Eleven chromosomal abnormalities were detected. The mean serum PAPP-A levels in cases of Down syndrome were 0.44 MOM at 9 weeks gestation, 0.15 MOM at 10 weeks, and 0.29 MOM at 11 weeks. The PAPP-A level at 10 weeks was below those of pregnancies which aborted spontaneously. At 11 weeks, the pregnancies with Down syndrome recorded the lowest PAPP-A levels at that gestation. On this small sample, offering chorionic villus sampling to women with singleton pregnancies and a PAPP-A level below 0.3 MOM (approximately 6.5 per cent of this at-risk group) would have detected all the Down syndrome fetuses at 10 weeks and 50 per cent at 11 weeks without selecting those cases destined to abort. This suggests that serum PAPP-A should continue to be investigated as a potential first-trimester screening test for Down syndrome. 相似文献
85.
A case of spontaneous abortion after transcervical CVS is presented. Despite no evidence of bacteria in the vagina and cervix prior to sampling and the prophylactic use of Metronidazole, pathological evidence of chorioamnionitis was found. The implications of this are discussed. 相似文献
86.
A disastrous flood in Ibadan City, Nigeria in April 1978 aroused public interest in the Ogunpa river channelization scheme which had earlier been embarked upon by government. A questionnaire survey of 399 residents near the river was designed to examine three issues: (a) the losses sustained and the people's reaction to and perception of the causes of the flood; (b) their perception of the present and future uses of the river; and (c) their perception of the prospects of the channelization scheme.The results show that about 75% of the respondents were affected by the flood; 41% each lost property worth about N2960.00. Yet, many could not hope to move out of the flood zone mainly because of shortage of residential accomodation in the city. The factors given as being responsible for the flood were poor drainage, heavy rains, refuse disposal in the river, shallowness of the river channel and the unplanned layout of streets and buildings. Indeed, the major use of the river has been as a refuse dump, so that it is heavily polluted. Many respondents would like the river to be reclaimed to alleviate some of the socioeconomic problems confronting them. Recreational use of the river was not much considered. Majority of respondents thought the channelization scheme would bring some benefit. But, they are sceptical about its lasting impact unless it is done within the framework of a comprehensive programme of urban land management and protection and the improvement of living conditions in the city. 相似文献
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R.F. Griffiths 《Process Safety and Environmental Protection》1996,74(4):289