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211.
Non-invasive prenatal screening (NIPS) has revolutionized the approach to prenatal fetal aneuploidy screening. Many commercial providers now offer analyses for sub-chromosomal copy number variations (CNVs). Here, we review the use of NIPS in the context of screening for microdeletions and microduplications, issues surrounding the choice of disorders tested for, and the advantages and disadvantages associated with the inclusion of microdeletions to current NIPS. Several studies have claimed benefits; however, we suggest that microdeletions have not demonstrated a low enough false positive rate to be deemed practical or ethically acceptable, especially considering their low positive predictive values. Because a positive NIPS result should be confirmed using diagnostic techniques, and false positive rates are as high as 90% for some microdeletions, diagnostic testing seems preferable when the goal is to maximize the detection of microdeletion or microduplication syndromes. 相似文献
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214.
An Edge Effect Caused by Adult Corn-Rootworm Beetles on Sunflowers in Tallgrass Prairie Remnants 总被引:1,自引:0,他引:1
Mark J. McKone Kendra K. McLauchlan † Edward G. Lebrun ‡ Andrew C. McCall§ 《Conservation biology》2001,15(5):1315-1324
Abstract: The once-extensive tallgrass prairie community of North America has been reduced to small remnants, many of which are surrounded by intensive corn ( Zea mays ) agriculture. We investigated adult corn-rootworm beetles (Chrysomelidae : Diabrotica spp.), important pests of corn, on sunflowers (Asteraceae : Helianthus spp . ) in prairie remnants in southeast Minnesota. Large numbers of beetles invaded the prairie from surrounding corn fields in late summer. D. barberi and D. virgifera were captured on sticky traps in all locations in the prairie, but abundance was much greater near the edge adjacent to corn. We observed D. barberi ( but not D. virgifera ) feeding extensively on sunflower pollen and occasionally on other flower parts, such as petals. Sunflowers located nearer corn fields sustained more floral damage than those farther from corn. To determine the effect of beetle damage on seed set, we enclosed sunflower heads in bags with either zero, two, or four D. barberi adults. Seed set was reduced in heads enclosed with D. barberi . Thus, this agricultural pest may interfere with the successful reproduction of sunflowers and possibly other prairie composites that flower in late summer. Given the small size of most prairie remnants and the abundance of this flower-feeding beetle in landscapes dominated by corn agriculture, D. barberi may affect the sustainability of prairie plant populations. 相似文献
215.
C. Annette Johnson Grald A. Richner Tomas Vitvar Nina Schittli Mark Eberhard 《Journal of contaminant hydrology》1998,33(3-4)
The objective of the investigation of the municipal solid waste incinerator (MSWI) bottom ash landfill, Landfill Lostorf, was to determine the residence time of water in the landfill and the flow paths through the landfill. Over a period of 22 months, measurements of rainfall, landfill discharge and leachate electrical conductivity were recorded and tracer experiments made. Over the yearly period 1995, approximately 50% of the incident rainfall was measured in the discharge. An analysis of single rain events showed that in winter, 90–100% of rainfall was expressed in the landfill discharge, whereas in summer months, the value was between 9 and 40% depending on the intensity of the rain event. The response to rainfall was rapid. Within 30–100 h, approximately 50% of water discharged in response to a rain event had left the landfill. The discharge was less than 4 l/min for approximately 50% of the measurement periods. Qualitative tracer studies with fluorescein, pyranine and iodide clearly showed the existence of preferential flow paths. This was further substantiated by quantitative tracer studies of single rain events using
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ratios and electrical conductivity measurements. The proportion of rainwater passing directly through the landfill was found to be between 20 and 80% in summer months and around 10% in winter months. The difference has been ascribed to the water content in the landfill. The average residence time of the water within the landfill has been estimated to be roughly 3 years and this water is the predominant component in the discharge over a yearly period. 相似文献
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217.
Major fluorinated chemical manufacturers have developed new short-chain per- and polyfluorinated substances with more favorable environmental, health and safety profiles. This study provides the first evaluation of the elimination half-life of perfluorohexanoic acid (PFHxA) from the blood of humans. PFHxA biomonitoring data were obtained from a recently published study of professional ski wax technicians. These data were analyzed to provide estimates of the apparent half-life of PFHxA from humans, and comparisons were made with kinetic studies of PFHxA elimination from mice, rats and monkeys. The apparent elimination half-life of PFHxA in highly exposed humans ranged between 14 and 49 d with a geomean of 32 d. The half-lives of PFHxA in mice, rats, monkeys and humans were proportional to body weight with no differences observed between genders, indicating similar volumes of distribution and similar elimination mechanisms among mammalian species. Compared to long-chain perfluoroalkyl acid analogs, PFHxA is rapidly cleared from biota. The consistent weight-normalized elimination half-lives for PFHxA in mammalian species indicates that results obtained from animal models are suitable for establishment of PFHxA benchmark dose and reference dose hazard endpoints for use in human risk assessments. 相似文献
218.
Implementing the UNCCD: Participatory challenges 总被引:1,自引:0,他引:1
Lindsay C. Stringer Mark S. Reed rew J. Dougill Mary K. Seely Martin Rokitzki 《Natural resources forum》2007,31(3):198-211
The United Nations Convention to Combat Desertification (UNCCD) emphasizes the need for public participation in land degradation assessment and rehabilitation. While participatory approaches are supported by a growing body of research and practice, meaningfully involving the people affected by land degradation is far from straightforward. This paper investigates the challenge of using the UNCCD as a guide to influence community participation in policy‐making and practice at national and local levels by analyzing experiences from three southern African countries. We show that the UNCCD represents a useful normative framework for addressing degradation problems, but that the participatory ethos is difficult to enact at the national level. Whilst there is increasing evidence that combining local and scientific knowledge using participatory mechanisms can deliver the benefits that the Convention strives to achieve, communication between researchers and practitioners, and those involved in implementing the UNCCD at the national level needs to be strengthened. Broad lessons and best practices in incorporating participatory practices into policy development are elucidated. Our case studies show that a range of mixed‐method, interdisciplinary approaches can enable policy‐makers and practitioners to meaningfully engage those who are affected by land degradation in its definition, assessment and rehabilitation. 相似文献
219.
This paper sets out to test the hypothesis that vertical mixing due to the dissipation of the internal tide accounts for a significant proportion of the total vertical mixing in a fjordic basin during a period of deep water isolation. During July and August 1999 two locations in the Clyde Sea were instrumented with moored RD Instruments Acoustic Doppler Current Profilers (ADCPs) and conductivity-temperature-pressure chains: Station C2, near the shallow entrance sill (55 m water depth), and station C1 in the deep basin (155 m water depth). A bottom pressure recorder was also deployed at station C3 by the seaward entrance to the Clyde Sea in the North Channel of the Irish Sea. A Free-falling Light Yo-yo shear microstructure profiler (FLY) was used to measure the dissipation rate of turbulent kinetic energy (TKE) throughout the water column over 25 h at both C1 and C2. These were interspersed with two-hourly conductivity-temperature-depth casts at both sites. The observations show agreement between the dissipation rate of TKE estimated by using a microstructure profiler and that estimated from the decay of the internal tide as measured by the two ADCPs. However, to account for all the implied mixing it is necessary to invoke an additional source of buoyancy flux, the most probable candidate mechanism is enhanced internal wave breaking near the sill and at the sloping boundaries of the deep basin. In addition, the vertical eddy diffusivity estimated from the micro-structure profiler (O(0.5 cm2 s–1) indicates that internal tide induced mixing away from any boundaries contributed significantly to the overall level of mixing which is required to account for the observed evolution of the deep basin water properties. 相似文献
220.
We present a model of species extinction rates that depends on the distribution of species and rates of habitat conversion. This model allows prediction of numbers of species lost as well as current extinction rates. We apply the model to plant species in the Neotropics. We examined distribution data for 51 angiosperm taxa, comprising 4258 species from Flora Neotropica monographs. Of these, 25.7% had been recorded as occurring in a single locality, with 12.8% and 9.5% being recorded from two or three localities respectively. Assuming that 18.7% of Neotropical forested area has been cleared since 1950, when 60,000 plant species existed, the model predicts that 3020 species will have been lost by 1992. At current deforestation rates, the entire Neotropics loses between 71 and 95 plant species per year. We also apply the model to individual Neotropical countries and find annual rates of within-country extinctions ranging from 0 per year in Belize to 63 per year in Ecuador. We suggest a means by which the model may be tested in the field. 相似文献