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21.
Increasing use of nickel oxide nanoparticles (NiO NPs) necessitates an improved understanding of their potential impact on human health. Previously, toxic effects of NiO NPs have been investigated, mainly on airway cells. However, information on effect of NiO NPs on human liver cells is largely lacking. In this study, we investigated the reactive oxygen species (ROS) mediated cytotoxicity and induction of apoptotic response in human liver cells (HepG2) due to NiO NPs exposure. Prepared NiO NPs were crystalline and spherical shaped with an average diameter of 44 nm. NiO NPs induced cytotoxicity (cell death) and ROS generation in HepG2 cells in dose-dependent manner. Further, ROS scavenger vitamin C reduced cell death drastically caused by NiO NPs exposure indicating that oxidative stress plays an important role in NiO NPs toxicity. Micronuclei induction, chromatin condensation and DNA damage in HepG2 cells treated with NiO NPs suggest that NiO NPs induced cell death via apoptotic pathway. Quantitative real-time PCR analysis showed that following the exposure of HepG2 cells to NiO NPs, the expression level of mRNA of apoptotic genes (bax and caspase-3) were up-regulated whereas the expression level of anti-apoptotic gene bcl-2 was down-regulated. Moreover, activity of caspase-3 enzyme was also higher in NiO NPs treated cells. To the best of our knowledge this is the first report demonstrating that NiO NPs caused cytotoxicity via ROS and induced apoptosis in HepG2 cells, which is likely to be mediated through bax/bcl-2 pathway. This work warrants careful assessment of Ni NPs before their commercial and industrial applications. 相似文献
22.
Adak T Kumar J Dey D Shakil NA Walia S 《Journal of environmental science and health. Part. B》2012,47(3):226-231
Controlled release (CR) formulations of imidacloprid (1-(6 chloro-3-pyridinyl methyl)-N- nitro imidazolidin-2- ylideneamine) were prepared using novel amphiphilic polymers synthesized from polyethylene glycol and aliphatic diacids employing encapsulation technique. The bioefficacy of the prepared CR formulations was evaluated against major pests of soybean, namely stem fly, Melanagromyza sojae Zehntmer and white fly, Bemisia tabaci Gennadius along with a commercial formulation at the experimental farm of Indian Agricultural Research Institute (IARI), New Delhi during kharif 2009 and 2010. Most of the CR formulations of imidacloprid gave significantly better control of the pests compare to its commercial formulations, however the CR formulations, Poly [poly (oxyethylene-1000)-oxy suberoyl] amphiphilic polymer based formulation performed better over others for controlling of both stem fly incidence and Yellow Mosaic Virus (YMV) infestation transmitted by white fly. Some of the developed CR formulations recorded higher yield over commercial formulation and control. Nodulation pattern of soybean was not affected due to treatment of CR and commercial formulations of imidacloprid. Also the residues of imidacloprid in seed and soil at harvest were not detectable for both CR and commercial formulations. 相似文献
23.
Najam Akhtar Shakil Jitendra Kumar Pankaj Alka Pandey Vivek Ahluwalia Manish K. Singh 《Journal of environmental science and health. Part. B》2013,48(4):344-349
A series of novel N-alkyl-N-[1-(2-hydroxyphenyl) ethyl]amines were synthesized as potential new agents to control pests. Their structures were confirmed on the basis of IR, NMR and elemental analyses. Six new N-alkyl-N-[1-(2-hydroxyphenyl) ethyl]amines were prepared by reduction of corresponding Schiff bases using sodium borohydride in 80–87 % yields. These compounds were tested for their antifungal activity against two pathogenic fungi viz., Rhizoctonia bataticola ITCC 0482 and Sclerotium rolfsii ITCC 5226 and for insecticidal activity against insects of stored grain pest Callosobruchus analis. Fungicidal bioassay revealed that compound N-Decyl-N-[1-(2-hydroxyphenyl)ethyl]amine, was highly effective against R. bataticola (ED50 6.86 mg L?1) which was comparable with that of commercial fungicide hexaconazole (ED50 6.35 mg L?1). Also compounds N-Heptyl-N-[1-(2-hydroxyphenyl)ethyl]amine, N-Octyl-N-[1-(2-hydroxyphenyl)ethyl]amine and N-Nonyl-N-[1-(2-hydroxyphenyl)ethyl]amine displayed promising fungitoxicity against same pathogen. However, compound N-Heptyl-N-[1-(2-hydroxyphenyl)ethyl]amine was also found to be effective against S. rolfsii (ED50 4.92 mg L?1 as against 1.27 mg L?1 for hexaconazole). Compound N-Hexyl-N-[1-(2-hydroxyphenyl)ethyl]amine was most effective as insecticide followed by compound N-Octyl-N-[1-(2-hydroxyphenyl)ethyl]amine. LC50 values for these compounds were 155.0 and 275.0 mg L?1 respectively as against 36.70 mg L?1 for commercial insecticide dichlorovos. The results obtained from bioassays indicate that this class of compounds can be utilized for the design of new substances endowed with pesticidal activities. 相似文献
24.
Kumelachew Mulu Loha Najam A. Shakil Jitendra Kumar Manish K. Singh Chitra Srivastava 《Journal of environmental science and health. Part. B》2013,48(7):687-691
In the present investigation, bioefficacy of developed β-cyfluthrin formulations, utilizing laboratory synthesized poly(ethylene glycols) based amphiphilic copolymers, were evaluated against Callosobruchus maculatus (Coleoptera: Bruchidae). The bioefficacy data indicated that the formulations developed by utilizing polymers having PEG – 1500 (3c) and PEG – 2000 (3d) as the hydrophilic segment showed greater efficacy after 14 days as evident from EC50 values (2.2 and 1.58 mg L?1 respectively). Also, release from the commercial SC formulation was faster than developed formulations as the commercial formulation had the lowest EC50 value on the first day (0.51 mg L?1). The mean EC50 of the commercial formulation against C. maculatus was quite high as compared to those of developed formulations. The results suggest that depending upon the polymer matrix used, the application rate of β-cyfluthrin can be optimized to achieve insect control at the desired level and period. The results described in this paper are promising and provide a comparison of developed formulations with the commercial one showing an earlier degradation of β-cyfluthrin in the latter and relatively prolonged activity in the former. 相似文献
25.
Mubarik Sumaira Liu Xiaoxue Malik Saima Shakil Wang Lijun Yu Yong Yu Chuanhua 《Environmental science and pollution research international》2021,28(36):49864-49876
Environmental Science and Pollution Research - Statistical evidence on breast cancer (BC) burden related to health and lifestyle risk factors are valuable for health policy-making. This study aimed... 相似文献
26.
Ahamed Maqusood Akhtar Mohd Javed Khan Mohd Abdul Majeed Alhadlaq Hisham Abdulaziz 《Environmental science and pollution research international》2021,28(14):17109-17118
Environmental Science and Pollution Research - Recent attention has been focused on reproductive toxicity of nanoscale materials in combination with pre-existing environmental pollutants. Due to... 相似文献
27.
Romshoo Shakil Ahmad Murtaza Khalid Omar Shah Waheed Ramzan Tawseef Ameen Ummer Bhat Mustafa Hameed 《Environmental science and pollution research international》2022,29(35):52732-52751
Environmental Science and Pollution Research - The Himalayan glaciers provide water to a large population in south Asia for a variety of purposes and ecosystem services. As a result, regional... 相似文献
28.
Azeem Waqas Ashraf Muhammad Shahzad Sher Muhammad Imtiaz Muhammad Akhtar Mumtaz Rizwan Muhammad Shahid 《Environmental science and pollution research international》2017,24(31):24376-24386
Environmental Science and Pollution Research - Relations between phosphate and arsenate are important but inconsistent to influence arsenic (As) phytotoxicity depending on many plant and soil... 相似文献
29.
M. Humayoun Akhtar 《Journal of environmental science and health. Part. B》2013,48(2):365-367
Residues of some veterinary drugs in animals and foods FAO Food and Nutrition Paper 41/5 Food and Agriculture Organization of the United Nations Rome 1993. 177 + xiii pages. $20.00 soft cover. ISBN # 92–5–103288–2 相似文献
30.
Akhtar Mohammad Nadeem Bani-Hani Khaldoon A. Akhtar J. N. Khan Rizwan Ahmad Nejem Jamal K. Zaidi Khansa 《Journal of Material Cycles and Waste Management》2022,24(5):1663-1678
Journal of Material Cycles and Waste Management - The extraction of unsustainable natural resources like sand and topsoil for construction is disturbing ecological balance, affecting local... 相似文献