Thermocoagulation of fetal sacrococcygeal teratoma

Fetal sacrococcygeal teratoma can lead to a high output cardiac failure resulting in hydrops fetalis. One of the prenatal therapeutic options is to occlude the feeding vessels by radiofrequency ablation. We present a case of fetal sacrococcygeal teratoma diagnosed at 13 weeks of gestation. The tumour increased in size more than 100-fold over 5 weeks causing polyhydramnios and cardiac and placental enlargement. Thermocoagulation was performed at 18 weeks' gestation by passing an insulated electric wire through an 18-gauge needle placed close to the feeding vessels of the tumour at its neck. Blood supply to the tumour was successfully reduced. However, fetal death was diagnosed 2 days after the procedure. We speculate that it may be safer to limit the extent of coagulation in one attempt but to repeat the procedure at a later stage when necessary. Copyright © 2002 John Wiley & Sons, Ltd.     

The effect of fetal gender on nuchal translucency at 10–14 weeks of gestation

Recent data have suggested that fetal nuchal translucency (NT) is affected by fetal gender. We investigated the size of this effect in 12 189 unselected pregnancies with known normal outcomes that had undergone NT measurements between 10 and 14 weeks of gestation. NT increased with gestation and was converted to multiples of the median (MoM) for the gestational day. The median NT MoM (95% CI) for female fetuses was 0.98 (0.97–0.99). This was significantly lower than that of the male fetuses (1.03; range1.02–1.04) (p<0.0005; Wilcoxon rank-sum test). The gender difference was not observed at 10 weeks but was observed from 11 weeks onwards. There is no obvious explanation for the above findings. Copyright © 2001 John Wiley & Sons, Ltd.     

Software for Sustainability Assessment: a Case Study in Quang Tri Province,Vietnam

Sustainable development is a widespread concept. Indicator selection and sustainability assessment are basic methods to analyse the sustainable development process. This study aims to develop a software application to select indicators and to allocate weightings to the indicators and the sub-indexes, so that they can be listed in a sustainability assessment. The Visual Basic software is used to develop a software package based on Delphi, analytic hierarchy, normalization and combination processes. Software for sustainability assessment was developed. Thirty-five indicators are selected as a first step of which eight health indicators and eight environmental ones and their sub-indexes are given weightings. The indicators are normalized. Sub-indexes are combined into a composite sustainable development index. The model is validated showing the ‘main features’ of the sustainability situation on health and environmental aspects in the Quang Tri province during the period 2000–2005. The results support the decision-making process of the competent authorities.     

Endocrine disruption effects of 2,2',4,4',6-pentabromodiphenylether (BDE100) in reporter gene assays

Polybrominated diphenyl ethers (PBDEs) constitute an important group of flame retardants. 2,2',4,4',6-Pentabromodiphenylether (BDE100) is a prominent PBDE congener in some human populations. The potential of BDE100 to modulate responses mediated by the estrogen (ER), thyroid hormone (ThR) or androgen receptors (AR) were investigated by use of transactivation reporter gene assays. The African green monkey kidney CV-1 cell transiently transfected with the constructed reporter gene plasmid ERE-TATA-Luc and pUAS-tk-Luc with luciferase (Luc) under control of the estrogen response (ERE), or thyroid hormone response (ThRE) elements were used to evaluate (anti)estrogen and thyroid effects of BDE100. The (anti)androgenic potency of BDE100 was also evaluated by use of MDA-kb2 cells, which were stably transfected with MMTV-luciferase. The assays displayed appropriate responses to known natural estrogen 17β-estradiol (E2), ThR ligand triiodothyronine (T3), and the AR agonist 5α-dihydrotestosterone (DHT). 10 or 50 μM BDE100 significantly up-regulated expression of Luc under control of the ER. Antiestrogenic potency was observed for BDE100 (IC50 = 6.21 μM). Co-exposure to 50 μM BDE100 significantly enhanced expression of Luc caused by 5 nM T3. BDE100 was antiandrogenic at 10 and 50 μM with an IC50 of 28.60 μM BDE100. These results suggest that BDE100 can modulate the endocrine system in multiple ways by interfering with several hormonal signaling pathways simultaneously.     

The effects of job complexity and autonomy on cohesiveness in collectivistic and individualistic work groups: a cross‐cultural analysis

Increased job complexity and autonomy have often been associated with improved performance in work groups. This study examines the mediating effect of group cohesiveness. The moderating effects of individualism/collectivism on the relationship between job characteristics (both complexity and autonomy) and cohesiveness are also tested. The sample consists of 381 teams drawn from the Hong Kong and U.S. branches of an international bank. The findings indicate that an increase in job complexity and/or task autonomy will increase group cohesiveness, which subsequently translates to better performance. The positive effects of job complexity and autonomy on group cohesiveness are also found to be more prominent for individualistic rather than collectivistic work groups. The theoretical implications of the results and the limitations of the study are also discussed. Copyright © 2003 John Wiley & Sons, Ltd.     

Distribution and assessment of Pb in the supergene environment of the Huainan Coal Mining Area,Anhui, China

Coal mining area is highly subject to lead (Pb) pollution from coal mining activities. Several decades of coal mining and processing practices in dozens of coal mines in the Huainan Coal Mining Area (HCMA) have led to the accumulation of massive amounts of coal gangue, which piled in dumps. In order to investigate the impacts of coal gangue dumps on Pb level in the supergene media of the HCMA, a systematic sampling campaign comprising coal gangue, soil, wheat, and earthworm samples was conducted. The average Pb content in the coal mining area soil is 24 mg/kg, which is slightly higher than the associated coal gangues (23 mg/kg) and markedly higher than reference region soil (12.6 mg/kg). Soil in the HCMA present a slight to moderate Pb contamination, which might be related to the weathering and leaching of coal gangue dumps. Lateral distribution of Pb in HCMA soil differed among individual coal mines. The soil profile distribution of Pb depends on both natural and anthropogenic contributions. Average Pb content is higher in roots than in stems, leaves, and wheat husks, while the Pb level in seeds exceeded the maximum Pb allowance for foods (Maximum Levels of Contaminants in Foods of China, GB 2762–2012). Earthworms in the selected area are significantly enriched in Pb, suggesting higher bio-available Pb level in soil in the HCMA.     

Fourier analysis of the roll-up and merging of coherent structures in shallow mixing layers

The current study investigates the role of nonlinearity in the development of two-dimensional coherent structures (2DCS) in shallow mixing layers. A nonlinear numerical model based on the depth-averaged shallow water equations is used to investigate temporal shallow mixing layers, where the mapping from temporal to spatial results is made using the velocity at the center of the mixing layer. The flow is periodic in the stream-wise direction and the transmissive boundary conditions are used in the cross-stream boundaries to prevent reflections. The numerical results are examined with the aid of Fourier decomposition. Results show that the previous success in applying local linear theory to shallow mixing layers does not imply that the flow is truly linear. Linear stability theory is confirmed to be only valid within a short distance from the inflow boundary. Downstream of this linear region, nonlinearity becomes important for the roll-up and merging of 2DCS. While the energy required for the merging of 2DCS is still largely provided by the velocity shear, the merging mechanism is one where nonlinear mode interaction changes the velocity field of the subharmonic mode and the gradient of the along-stream velocity profile which, in turn, changes the magnitude of the energy production of the subharmonic mode by the velocity shear implicitly. The nonlinear mode interaction is associated with energy up-scaling and is consistent with the inverse energy cascade which is expected to occur in shallow shear flows. Current results also show that such implicit nonlinear interaction is sensitive to the phase angle difference between the most unstable mode and its subharmonic. The bed friction effect on the 2DCS is relatively small initially and grows in tandem with the size of the 2DCS. The bed friction also causes a decrease in the velocity gradient as the flow develops downstream. The transition from unstable to stable flow occurs when the bed friction balances the energy production. Beyond this point, the bed friction is more dominant and the 2DCS are progressively damped and eventually get annihilated. The energy production by the velocity shear plays an important role from the upstream end all the way to the point of transition to stable flow. The fact that linear stability theory is valid only for a short distance from the inflow boundary suggests that some elements of nonlinearity is incorporated in the mean velocity profile in experiments by the averaging process. The implicit nature of nonlinear interaction in shallow mixing layers and the sensitivity of the nonlinear interaction to phase angle difference between the most unstable mode and its subharmonic allows local linear theory to be successful in reproducing features of the instability such as the dominant mode of the 2DCS and its amplitude.     

Trace metals in mussels from mariculture zones, Hong Kong

In 1997, concentrations of cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb) and nickel (Ni) were analysed in green-lipped mussels (Perna viridis) from three mariculture zones located in the north-east (Kat O), south (Lo Tik Wan) and to the west (Ma Wan) of Hong Kong. Spatial differences in the concentration of metals were found, chromium and copper were higher at Ma Wan and Lo Tik Wan compared to Kat O in the north-east. In contrast, the highest levels of lead (mean = 4.37 microg/g dry wt) were recorded at Kat O. There were no differences in the level of nickel between the study sites. A comparison of the metal concentrations in mussels with the results of a previous study seven years before, in 1990, showed a twofold increase in the mean levels of cadmium for all three sites. However, levels of the other metals in 1997 were lower by 12-32% for chromium, 32-39% for copper and 24-25% for nickel. The greatest reductions were recorded for lead: Kat O (39%), Ma Wan (51%) and Lo Tik Wan (75%). This may be related to the introduction of lead-free petrol in 1991. Despite the apparent reduction in some heavy metal bioaccumulation between 1990 and 1997, from a public health risk perspective, the data suggest a continued need for monitoring of heavy metals in mussels from mariculture zones.