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排序方式: 共有106条查询结果,搜索用时 31 毫秒
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Ulrich Harréus MD PhD Philipp Baumeister Norbert Kleinsasser Maximilian Reiter Beatrice Bachmeier Christoph Matthias 《毒物与环境化学》2013,95(2):205-214
The etiology of salivary gland malignancies still remains unclear. Metal compounds are of special interest since they show ubiquitous presence in the environment, are present in many working places, and are accepted (co-)carcinogens in some other malignancies. Metals enter the body as xenobiotics by inhalation or ingestion. This study investigated the genotoxic potential of sodium dichromate (Na2Cr2O7), nickel sulfate (NiSO4), cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) on human salivary gland cells and lymphocytes. Macroscopically healthy tissue of salivary glands was harvested from 46 patients during surgery and isolated to single cells by enzymatic digestion. The cells were incubated with Na2Cr2O7, NiSO4, CdSO4 or ZnCl2. Na2Cr2O7 was also incubated in combination with the other metal compounds listed. Carcinogenic and co-carcinogenic effects of cadmium were tested by incubation with Na2Cr2O7 and consecutive repair intervals. DNA damage and repair were evaluated by the Comet assay, determining DNA-strand breaks. The extent of damage was quantified using a digital analysis system. Na2Cr2O7 produced significantly enhanced DNA-strand breaks in human salivary gland tissue and lymphocytes. All other metal compounds exerted no damaging effect on both cell types. Co-incubation of Na2Cr2O7 with the other metals revealed a significant additive effect only for CdSO4. Specific analysis of the influence of cadmium showed a reduction of DNA-repair after Na2Cr2O7-induced strand breaks in salivary gland cells. This study provides evidence that exposure to distinct metals may significantly contribute to malignant salivary gland tumors. In consequence, further studies as epidemiological and toxicological data are warranted to determine the role of distinct metals as potential (co-) carcinogens. 相似文献
13.
Manuela Bartel Stefanie Hartmann Karola Lehmann Kai Postel Humberto Quesada Eva E. R. Philipp Katja Heilmann Burkhard Micheel Heiko Stuckas 《Marine Biology》2012,159(10):2195-2207
Sperm proteins of the marine sessile mussels of the Mytilus edulis species complex are models to investigate reproductive isolation and speciation. This study aimed at identifying sperm proteins and their corresponding genes. This was aided by the use of monoclonal antibodies that preferentially bind to yet unknown sperm molecules. By identifying their target molecules, this approach identified proteins with relevance to Mytilus sperm function. This procedure identified 16 proteins, for example, enkurin, laminin, porin and heat shock proteins. The potential use of these proteins as genetic markers to study reproductive isolation is exemplified by analysing the enkurin locus. Enkurin evolution is driven by purifying selection, the locus displays high levels of intraspecific variation and species-specific alleles group in distinct phylogenetic clusters. These findings characterize enkurin as informative candidate biomarker for analyses of clinal variation and differential introgression in hybrid zones, for example, to understand determinants of reproductive isolation in Baltic Mytilus populations. 相似文献
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Philipp Balzer Klaus Peter Rippe Peter Schaber 《Journal of Agricultural and Environmental Ethics》2000,13(1-2):7-27
The 1992 incorporation of an article by referendum in the Swiss Constitution mandating that the federal government issue regulations
on the use of genetic material that take into account the dignity of nonhuman organism raises philosophical questions about
how we should understand what is meant by “the dignity of nonhuman animals,” and about what sort of moral demands arise from
recognizing this dignity with respect to their genetic engineering. The first step in determining what is meant is to clarify
the difference between dignity when applied to humans and when applied to nonhumans. Several conceptions of human dignity
should be rejected in favor of a fourth conception: the right not to be degraded. This right implies that those who have it
have the cognitive capacities that are prerequisite for self-respect. In the case of nonhuman organisms that lack this capacity,
respecting their dignity requires the recognition that their inherent value, which is tied to their abilities to pursue their
own good, be respected. This value is not absolute, as it is in the case of humans, so it does not prohibit breeding manipulations
that make organisms more useful to humans. But it does restrict morally how sentient animals can be used. In regard to genetic
engineering, this conception requires that animals be allowed the uninhibited development of species specific functions, a
position shared by Holland and Attfield, as opposed to the Original Purpose conception proposed by Fox and the Integrity of
the Genetic Make-up position proposed by Rolston. The inherent value conception of dignity, as here defended, is what is meant
in the Swiss Constitution article.
This paper is a slightly revised version of a paper that had been published in German in 1998 (“Menschenwürde vs. Würde der
Kreatur,” Freiburg i.Br.). 相似文献
16.
D'Affonseca FM Blum P Finkel M Melzer R Grathwohl P 《Journal of contaminant hydrology》2008,102(1-2):120-139
A coal tar contaminated site was characterized using traditional and innovative investigation methods. A careful interpretation of hydrogeological and hydrogeochemical data allowed for the conceptualization of the heterogeneous coal tar distribution in the subsurface. Past and future contaminant release from the source zone was calculated using a modeling framework consisting of a three-dimensional steady-state groundwater flow model (MODFLOW) and two hydrogeochemical models (MIN3P). Computational time of long-term simulations was reduced by simplifying the coal tar composition using 3 composite and 2 individual constituents and sequential application of a 2D centerline model (for calibration and predictions) and a 3D model (only for predictions). Predictions were carried out for a period of 1000 years. The results reveal that contaminant mass flux is governed by the geometry of zones containing residual coal tar, amount of coal tar, its composition and the physicochemical properties of the constituents. The long-term predictions made using the 2D model show that even after 1000 years, source depletion will be small with respect to phenanthrene, 89% of initial mass will be still available, and for the moderately and sparingly soluble composite constituents, 60% and 98%, respectively. 相似文献
17.
A long-term sampling method for PCDF/D in emissions from combustion facilities is presented. The sampling of PCDF/D was performed over a four week period. The results are compared to results of four one-week measurements. 相似文献
18.
A bioaccumulation study was performed with the endobenthic freshwater oligochaete Lumbriculus variegatus MULLER exposed to the radiolabelled synthetic steroid 17alpha-ethinylestradiol (14C-EE2) in a spiked artificial sediment. Concentration of total radioactivity increased constantly and almost linearly during 35 days of exposure. The accumulation factor normalised to worm lipid content and sediment TOC (AFlipid/OC) was 75 at the end of the uptake period, but a steady state was not reached. Uptake kinetics were calculated fitting the measured AFs to a kinetic rate equation for constant uptake from sediment using iterative non-linear regression analysis. After 10 days of elimination in contaminant-free sediment 50% of the accumulated total radioactivity was excreted by the worms. Extracts from L. variegatus sampled at the end of the uptake phase were analysed by thin layer chromatography (TLC). The results showed that 6% of the total radioactivity incorporated by the worms was 14C-EE2. After treatment of extracts with beta-glucuronidase the amount of 14C-EE2 increased to 84%. These results suggest that L. variegatus has the potency to accumulate high amounts of conjugated EE2. Hence, a transfer of EE2 to benthivores and subsequent secondary poisoning of predators might be possible. 相似文献
19.
Frances E. Barry Patrick J. Weatherhead David P. Philipp 《Behavioral ecology and sociobiology》1992,30(3-4):193-199
Summary For most animal species, a single mating is sufficient to fertilize all of a female's offspring. As a result, females do not usually increase their reproductive success with successive matings. However, multiple paternity has been discovered in many animal taxa. We demonstrate that the majority of female water snakes in a wild population mate with more than one male for each litter. Field observations indicated that a highly skewed operational sex ratio (3.6:1 M : F) during the breeding season, while not necessary for multiple paternity to occur, created ample opportunity for females to mate multiply. Protein electrophoretic analysis showed that at least 12 of 14 litters from naturally mated females had more than one father. Since male snakes can not force copulations, multiple matings seem likely to be the result of female choice.
Offprint requests to: F.E. Barry 相似文献
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