Role of the second-trimester ‘genetic sonogram’ for Down syndrome screen in the era of first-trimester screening and noninvasive prenatal testing

Ultrasonography for the screening of Down syndrome was first introduced about 25 years ago. Different combinations of markers detectable at second-trimester ultrasonography have been proposed under the banner of ‘genetic sonogram’. In recent years, several developments in first-trimester screening and the recent introduction of noninvasive prenatal testing for aneuploidy screening have had important implications for the prevalence of these conditions in the second-trimester and the screening performance of a genetic sonogram. Several second-trimester sonographic markers for Down syndrome have been reported; meta-analysis has shown that the most powerful predictors are mild ventriculomegaly, increased nuchal fold, hyperechoic bowel, and absent or hypoplastic nasal bone. Whereas use of individual markers should be discouraged and scoring systems of multiple markers are now obsolete, use of combined likelihood ratio and logistic regression analysis formulae provides better accuracy. However, there is significant heterogeneity in results among studies. Despite such limitations, the genetic sonogram will continue to have a place in prenatal screening, particularly in twin and higher-order multiple pregnancies, in countries with limited access to the most recent genetic screening tests, in cases with borderline results at maternal serum screening tests, and as noninvasive supplementary test for high-risk women reluctant to undergo invasive diagnostic testing. © 2014 John Wiley & Sons, Ltd.     

Aluminium flows in vehicles: enhancing the recovery at end-of-life

The transportation sector constitutes the major end-use market for aluminium-containing products and expectations for the future do indicate that aluminium will increase at 140 kg per vehicle. Moreover, up to 75 % aluminium recycled in Europe is used in transportation: thus, metal scrap recovered from ELVs is a key lever to act for closing material cycles. However, although the management chain of ELVs has an established procedure and aluminium scrap is usually recovered in shredding plants, a considerable fraction of the metal particles ends up in the light fraction called car fluff and is then landfilled. In this study we investigated potential of enhancing the recovery of aluminium scrap from the light fluff treatment. With this goal, the quantity of aluminium embedded in the Italian transport sector in the last 62 years was estimated, and a campaign of characterization in size and shape distribution of aluminium particles in the light fluff output has been carried out. The results estimated up to about 560,000 tons of metal are potentially recoverable from the treatment of light fluff at current operating conditions, but relevant improvements may be achieve when size and shape distribution criteria are adopt to implement eddy currents separation for a quantitative metal recovery.     

A simplified approach to address turbulence modulation in turbidity currents as a response to slope breaks and loss of lateral confinement

Turbidity currents traversing canyon-fan systems flow over bed slopes that decrease in the downstream direction. This slope decrease eventually causes turbidity currents to decelerate and enter a net-depositional mode. When the slope decrease is relatively rapid in the downstream direction, the turbidity current undergoes a concomitantly rapid and substantial transition. Similar conditions are found when turbidity currents debouch to fan systems with loss of lateral confinement. In this work a simplified approach to perform direct numerical simulation of continuous turbidity currents undergoing slope breaks and loss of lateral confinement is presented and applied to study turbulence modulation in the flow. The presence of settling sediment particles breaks the top–bottom symmetry of the flow, with a tendency to self-stratify. This self-stratification damps turbulence, particularly near the bottom wall, affecting substantially the flow’s ability to transport sediment in suspension. This work reports results on two different situations: turbidity currents driven by fine and coarser sediment flowing through a decreasing slope. In the case of fine sediment, after the reduction in the slope of the channel, the flow remains turbulent with only a modest influence on turbulence statistics. In the case of coarse sediments, after the change in slope, turbulence is totally suppressed.     

Prehibernating aggregations of Polistes dominulus: an occasion to study early dominance assessment in social insects

At a very early age several mammals establish a first dominance hierarchy, which often persists into adulthood. Social wasps offer an excellent opportunity to study such a phenomenon in insects. Indeed, foundresses of several paper wasps meet in clusters to hibernate from September to March. In spring, wasps found new associative nests where linear hierarchies occur. In the first phase of hibernation, clustering Polistes dominulus wasps show most of the social interactions occurring on the nest 6 months later. At the emergence from diapause, some females already show some behavioral and physiological traits typical of dominant individuals. Here, we investigated the significance of the interactions in the autumnal clusters. We demonstrated that in a given pair, it is more likely that the dominant wasp in autumn becomes the alpha female in spring after the nest foundation phase occurred. Moreover, we showed that dominant females in clusters have both larger body size and ovaries. As ovarian development mainly depends on the social context, our findings seem to indicate that social factors affect the tendency to dominate in aggregations. Furthermore, we suggest that some females may reinforce their physiological status by dominating in clusters, thus increasing the probability to become dominant in spring.     

Environmental features of two commercial surfactants widely used in soil remediation

One of the main limitations for a wider application of surfactants in soil remediation is the lack of knowledge about environmental fate and toxicity of surfactant itself especially for in situ application. Sorption behaviour, biodegradability, toxicity of parent compound and its metabolites are important processes that affect environmental fate of surfactants in site remediation applications. Tween 80 (poly(oxyethylene)(20)-sorbitane monooleate) and Aerosol MA+80 (dihexyl sodium sulfosuccinate) are surfactants that have been tested in laboratory and field scale remediation of soil and groundwater. In this work, the sorption and biodegradability of these surfactants were assessed to provide conditions and limitations for their use. The soil used in this experimentation was analysed for organic carbon content, soil bacteria, and size fraction and resulted to be a good model because is characterised by mean values for almost all considered parameters. Tween 80 showed high degree of biodegradability but a high affinity for soil matrix. Results suggest that Tween 80 could find its best application in ex situ solid phase remediation like ex situ bioremediation; its high affinity to soil could limit in situ applications. Biodegradation tests for Aerosol MA+80 show low degree of biodegradability and mineralisation. Biodegradation experiments, coupled with analysis of toxicity, could support the hypothesis that degradation of Aerosol MA+80 is not complete and leads to an accumulation of intermediates with at least the same toxicity of the parental compound. Therefore, aquifer remediation application with Aerosol MA+80 has to be conducted with necessary precautions to avoid product loss and excess surfactant should be flushed from the soil.