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排序方式: 共有334条查询结果,搜索用时 15 毫秒
331.
Sophie Plumejeaud Amelia Paula Reis Virginie Tassistro Carla Patinha Yves Noack Thierry Orsière 《Environmental geochemistry and health》2018,40(1):127-144
Due to their behavioral characteristics, young children are vulnerable to the ingestion of indoor dust, often contaminated with chemicals that are potentially harmful. Exposure to potentially harmful elements (PHEs) is currently exacerbated by their widespread use in several industrial, agricultural, domestic and technological applications. PHEs cause adverse health effects on immune and nervous systems and can lead to cancer development via genotoxic mechanisms. The present study is an integrated approach that aims at assessing the genotoxicity of bioaccessible PHEs following ingestion of contaminated house dust. A multidisciplinary methodology associating chemical characterization of five house dust samples, extraction of the bioaccessible PHEs in gastric extracts by the unified BARGE method, determination of the bioaccessible fraction and in vitro genotoxicity of gastric extracts in adenocarcinoma gastric human (AGS) cells was developed. The five gastric extracts induced dose-dependent genotoxicity in AGS cells. Copper (bioaccessible concentration up to 111 mg/kg) was probably the prevalent PHE inducing primary DNA damage (up to 5.1-fold increase in tail DNA at 0.53 g/l of gastric extract). Lead (bioaccessible concentration up to 245 mg/kg) was the most prevalent PHE inducing chromosome-damaging effects (r = 0.55; p < 0.001 for micronucleated cells induction). The association of principal component analysis and Spearman’s correlations was decisive to understand the chromosome-damaging properties of the bioaccessible PHEs in AGS cells. This methodology could be used on a larger-scale study to provide useful information for science-based decision-making in regulatory policies, and a better estimation of human exposure and associated health risks. 相似文献
332.
El Mountassir Otman Bahir Mohammed Ouazar Driss Chehbouni Abdelghani Carreira Paula M. 《Environmental science and pollution research international》2022,29(12):17132-17149
Environmental Science and Pollution Research - Groundwater aquifers in Morocco’s coastal regions are under serious threat as a result of climate change. This study was conducted to evaluate... 相似文献
333.
Corrêa Furtini Ana Carolina Silva Brito Flávia Maria Guimarães Junior Mario Anteveli Osajima Furtini Josy de Matos Alves Pinto Luciana de Paula Protásio Thiago Mendes Lourival Marin Guimarães Junior José Benedito 《Environmental science and pollution research international》2022,29(44):66562-66577
Environmental Science and Pollution Research - In recent years, research has been conducted in search of alternative adhesives that are less harmful to human health and the environment. Cardanol... 相似文献
334.
Sanchez Bustamante-Bailon Ana Paula Margenot Andrew Cooke Richard A. C. Christianson Laura E. 《Environmental science and pollution research international》2022,29(5):6733-6743
Environmental Science and Pollution Research - Denitrifying woodchip bioreactors are a practical nitrogen (N) mitigation technology but evaluating the potential for bioreactor phosphorus (P)... 相似文献