Climatic variations in the Eastern Mediterranean Sea area

A very dry climate which prevailed during the last glacial maximum of the Pleistocene from India to the Sahara, was replaced by variable weather conditions with alternating more or less humid phases, starting from the Pleistocene-Holocene transition period and lasting up to about 3000 years ago, when present arid conditions set in. A particularly wet phase is recognized throughout the region some 5000 years ago. Phase shifts within the region and in particular changes in rain distribution patterns, are interpreted as due to shifting spheres of influence of the monsoonal circulation, of Atlantic depressions and moisture originating from the Mediterranean Sea. The condition of the Mediterranean Sea itself, which is influenced by runoff and melt waters from the European Continent and by the Nile floods, as well as by the eustatic sea-level changes, is not a good indicator of local climate conditions.     

Peptidchemie heute

Peptide chemistry has reached a plateau on which more work is devoted to the improvement of known basic principles than to the development of really new methods. As a consequence, routine syntheses of peptides concentrate on few protecting groups and coupling procedures only. The recent progress in purification of peptides by liquid chromatography helped to promote this trend. Meanwhile, recombinant technology permits the synthesis of proteins and possibly of some lower peptides, too. It cannot compete, however, with chemical solid-phase synthesis of a newly discovered peptide with up to about 40 amino acids in speed but may take over the synthesis for large-scale production. Peptides containing modified or non-natural structures, which are often superior to the natural compounds as drugs, will remain subject of chemical synthesis, too. Present research focuses on the role of peptide and protein factors in the immune response and on structure and biological activities of neuropeptides.     

Vitamins,folic acid and neural tube defects: Comments on investigations in the United States

No clear answer concerning whether multivitamin/folate supplementation prevents neural tube defects (NTDs) is provided by three studies in the United States. All these studies are occurrence in nature, no recurrence studies having been conducted. The Atlanta Birth Defects Study is subject to pronounced memory and recall biases, the length between event and interview being as long as 16 years. In a second study (Boston University), objections can be raised to certain aspects of the experimental design, and the claim that 22 per cent of women started vitamins sufficiently early after pregnancy diagnosis to influence NTD formation is suspicious. Our NICHD case control study of 541 women in California and Illinois revealed no evidence for multivitamins or folic acid preventing NTDs. U.S. public policy-makers face difficulties in applying results of recurrence or occurrence studies in high-risk areas to low-risk areas in the U.S.