Determination of sorption coefficients of pharmaceutically active substances carbamazepine, diclofenac, and ibuprofen, in sandy sediments

Laboratory batch studies were conducted to characterize the sorption behavior of three pharmaceutically active substances (carbamazepine, diclofenac, and ibuprofen) in different sediment types. The sediments were natural sandy sediments from the water saturated zone and the unsaturated zone in the Berlin (Germany) area. They are characterized as medium and fine-grained sands, both with low organic carbon content. The results of the experiments show that sorption coefficients were generally quite low. Distribution coefficients (K(d) values) determined by the batch experiments varied from 0.21 to 5.32 for carbamazepine, 0.55 to 4.66 for diclofenac, and 0.18 to 1.69 for ibuprofen. Comparison of the organic carbon normalized sorption coefficient K(OC) values based on correlation equations with actual experimental data revealed that the calculated data for carbamazepine is of the same order as the experimental data. For diclofenac and ibuprofen the calculated values are much higher than the experimental data, showing a much higher mobility of diclofenac and ibuprofen in natural aquifer sediments than indicated by correlation equations based on octanol water distribution coefficients.     

Neurobiology of learning and memory: The honeybee as a model system

Conditioning experiments with bees demonstrate surprising similarities between the well studied laboratory mammals and honeybees. These similarities appear both on the behavioral level and the neural organization of memory. The paper speculates on the basis of these similarities, and the idea of common neural elements is favored.     

MODELING TIDAL HYDRODYNAMICS OF SAN DIEGO BAY,CALIFORNIA1

ABSTRACT: In 1983, current data were collected by the National Oceanic and Atmospheric Administration using mechanical current meters. During 1992 through 1996, acoustic Doppler current profilers as well as mechanical current meters and tide gauges were used. These measurements not only document tides and tidal currents in San Diego Bay, but also provide independent data sets for model calibration and verification. A high resolution (100-m grid), depth-averaged, numerical hydrodynamic model has been implemented for San Diego Bay to describe essential tidal hydrodynamic processes in the bay. The model is calibrated using the 1983 data set and verified using the more recent 1992–1996 data. Discrepancies between model predictions and field data in both model calibration and verification are on the order of the magnitude of uncertainties in the field data. The calibrated and verified numerical model has been used to quantify residence time and dilution and flushing of contaminant effluent into San Diego Bay. Furthermore, the numerical model has become an important research tool in ongoing hydrodynamic and water quality studies and in guiding future field data collection programs.     

Development of rapid,cost effective coral survey techniques: tools for management and conservation planning

Coral reefs are highly dynamic and productive marine ecosystems, providing habitat and refuge for an enormous number of species including fish, invertebrates and algae. With increased anthropogenic pressures and global climate change, many coral reefs are rapidly declining. Currently, there is limited knowledge on condition and community assemblage composition of shallow fringing coral reefs along the south-eastern coast of Queensland, Australia. With increased demand to determine existence of coastal fringing reefs by National Regional Management groups, a rapid cost effective method to determine reef composition and condition was required. The aim of this study was to determine the benthic structure and extent of two small coastal fringing reefs (Hummock Hill Reef and Stringers Reef) along the Southern Great Barrier Reef. Reef substrate assessments were carried out using a rapid assessment technique and a Point Intercept Method (PIM). The data were analysed and classified using a Geographic Information System (GIS). Percent substrate cover was calculated using a visual basic image analysis program. The Point intercept method showed higher accuracy over the rapid assessment technique (up to 15–40% difference) and was thus deemed a more suitable classification tool for reefs with high structural complexity and heterogeneity. This study focused on piloting a rapid, cost effective Point Intercept Technique using random point count methodology to document coral benthic habitat and extent over a commonly used rapid assessment method as a tool for reef coastal management and conservation. The two techniques were compared and substrate classification success, limitations and errors were discussed.     

A weight-adjusted Peto’s test when cause of death is not assigned

A new statistical testing approach using a weighted logrank statistic is developed for rodent tumorigenicity assays that have a single terminal sacrifice but not cause-of-death data. Instead of using cause-of-death assignment by pathologists, the number of fatal tumors is estimated by a constrained nonparametric maximum likelihood estimation method. For data lacking cause-of-death information, the Peto test is modified with estimated numbers of fatal tumors and a Fleming–Harrington-type weight, which is based on an estimated tumor survival function. A bootstrap resampling method is used to estimate the weight function. The proposed testing method with the weight adjustment appears to improve the performance in various situations of single-sacrifice animal experiments. A Monte Carlo simulation study for the proposed test is conducted to assess size and power of the test. This testing approach is illustrated using a real data set.     

Development and application of protocols for the determination of response of real-time particle monitors to common indoor aerosols

Protocols have been developed and applied for the generation of aerosols that are likely to be comparable to those encountered in field settings for the calibration of easily transportable/portable real-time particle monitors. Aerosols generated were simulated environmental tobacco smoke, cedar wood smoke, cooking oil fumes, and propane stove particles. The time-integrated responses of three nephelometers and a monitor for particle-bound polynuclear aromatic hydrocarbons (PAH) were compared with gravimetric respirable suspended particulate matter (RSP) in a controlled-atmosphere chamber. In general, the monitor responses increased linearly with increasing mass concentration. However, the two monitors that reported mass per volume concentrations tended to overreport the actual RSP concentrations by factors up to 4.4. The real-time PAH monitor did not respond to cooking oil fumes, indicative of little PAH being present in the aerosol. One of the monitors that has been used in a variety of studies reported in the literature (DustTrak) was collocated with gravimetric RSP samplers in several hospitality venues in the Louisville, KY, area. Field studies indicated that the units overreported actual RSP concentrations by factors of 2.6-3.1, depending on whether the sampling was conducted in the nonsmoking or smoking sections of the facilities.     

PREDICTING CHANGE IN NON-LINEAR SYSTEMS

Complex systems are characterizedby surprising switches to new behaviours. Evaluating and predicting these changes demands anunderstanding of the behaviour of the whole system. The combined ecosystem-climate system shows chaoticor pseudorandom behaviour, stochastic or trulyrandom behaviour, as well as simple bifurcation andsemi-stability. Semistability involves the suddenchange from a destabilized attractor to a newstable attractor which may occur after an apparentlyunpredictable time delay. We present some recentresults for analyzing time series data and for usingsimulations of non-linear models to predict these changes.     

Interdisciplinary studies on the technical and economic feasibility of deep underground coal gasification with CO<Subscript>2</Subscript> storage in bulgaria

This paper presents the outcome of a feasibility study on underground coal gasification (UCG) combined with direct carbon dioxide (CO₂) capture and storage (CCS) at a selected site in Bulgaria with deep coal seams (>1,200 m). A series of state-of-the-art geological, geo-mechanical, hydrogeological and computational models supported by experimental tests and techno-economical assessments have been developed for the evaluation of UCG-CCS schemes. Research efforts have been focused on the development of site selection requirements for UCG-CCS, estimation of CO₂ storage volumes, review of the practical engineering requirements for developing a commercial UCG-CCS storage site, consideration of drilling and completion issues, and assessments of economic feasibility and environmental impacts of the scheme. In addition, the risks of subsidence and groundwater contamination have been assessed in order to pave the way for a full-scale trial and commercial applications. The current research confirms that cleaner and cheaper energy with reduced emissions can be achieved and the economics are competitive in the future European energy market. However the current research has established that rigorous design and monitor schemes are essential for productivity and safety and the minimisation of the potential environmental impacts. A platform has been established serving to inform policy-makers and aiding strategies devised to alleviate local and global impacts on climate change, while ensuring that energy resources are optimally harnessed.