Radioactive contamination from medical uses and recent regulatory activity in the U.S.A.

Recent publications relating to environmental radioactive contamination from medical uses are described. It appears that the unprecented growth of medical uses of radionuclide continues in the United States; hospital effluents are not a measurement problem; and the regulatory climate is uncertain. The major need, appears to be in the reduction or control of medical radiation exposure to the patient from diagnosis and therapy.     

Polycyclic aromatic hydrocarbons storage by Fusarium solani in intracellular lipid vesicles

Accumulation and elimination of polycyclic aromatic hydrocarbons (PAHs) were studied in the fungus Fusarium solani. When the fungus was grown on a synthetic medium containing benzo[a]pyrene, hyphae of F. solani contained numerous lipid vesicles which could be stained by the lipid-specific dyes: Sudan III and Rhodamine B. The fluorescence produced by Rhodamine B and PAH benzo[a]pyrene were at the same locations in the fungal hyphae, indicating that F. solani stored PAH in pre-existing lipid vesicles. A passive temperature-independent process is involved in the benzo[a]pyrene uptake and storage. Sodium azide, a cytochrome c oxidation inhibitor, and the two cytoskeleton inhibitors colchicine and cytochalasin did not prevent the transport and accumulation of PAH in lipid vesicles of F. solani hyphae. F. solani degraded a large range of PAHs at different rates. PAH intracellular storage in lipid vesicles was not necessarily accompanied by degradation and was common to numerous other fungi.     

How the sizewell B inquiry is grappling with the concept of acceptable risk

There is no agreed level of safety that is ‘acceptable’. Those responsible for managing and regulating safety believe that they can establish adequate parameters, but they recognize that those standards must meet with ‘public approval’. This paper examines one way in which that approval is sought, namely the quasijudicial examination of the merits of a proposal to construct Britain's first pressurized water reactor at the Sizewell B site on the Suffolk coast. The authors argue that the Sizewell B Inquiry appears to operate on the assumption that acceptable risk levels can be determined through argument and cross-examination. In its approach to the determination of acceptable risk the Inquiry seems dependent on professional judgement and expertise as assessed by legal minds trained to sift evidence. To ensure that all the necessary evidence comes before it, the Inquiry has established procedures to initiate the preparation and examination of expert viewpoints. The authors examine how far this approach is likely to command public confidence, and the extent to which the Inquiry pinned down the elusive concept of acceptable risk.     

Indian mineral resources — a short review

Though India's iron ore and manganese exports are a major source of foreign exchange, the continent lacks sufficient reserves of many important minerals, or has only recently exploited known reserves on an adequate scale. This article reviews India's mineral resources and points out trends in exploration and production.     

Synthesis and recommendations of the economic evaluation of OHS interventions at the company level conference

PROBLEM: In today's economic environment, enterprises may not be able to fund every new project aimed at promoting health and safety in the workplace. Company level economic evaluation of interventions can provide guidance in sound business decision-making. The Economic Evaluation of Occupational Health and Safety Interventions at the Company Level Meeting brought together members of the global occupational safety and health community interested in encouraging the use of economic knowledge and tools to evaluate economic gains from occupational health and safety interventions. DISCUSSION: Discussions of the six models presented explored similarities, reliability, and potential use by corporate enterprises, small and medium enterprises, developing and transitioning nations, and economic theorists. Each group provided specific projects that could be pursued to advance knowledge in the area of economic evaluation at the company level. CONCLUSION: This conference established pathway to incorporate economic evaluation of health and safety interventions or programs at the workplace.     

Extracellular amylase(s) production by fungi Botryodiplodia theobromae and Rhizopus oryzae grown on cassava starch residue

The fungi Botryodiplodia theobromae and Rhizopus oryzae produce extracellular amylase when grown on a liquid medium containing 2% (WN) soluble starch or cassava starch residue(CSR) (as starch equivalent), a waste generated after extraction of starch from cassava, as the sole carbon source. Using CSR as the sole carbon source, the highest amylase activity of 3.25 and 3.8 units (mg, glucose released x ml(-1) x h(-1)) were obtained in shake flask cultures during the late stationary phase of growth of B. theobromae and R. oryzae, respectively. These values were slightly lower than the values obtained using soluble starch as the carbon source. Maximum enzyme synthesis in CSR incorporated medium occurred at the growth temperature of 30 degrees C and pH 6.0. Presence of inorganic NH4+ salts like ammonium acetate and ammonium nitrate in culture medium yielded more amylase than the other nitrogen sources. Amylase(s) production in the controlled environment of a Table-Top glass Jar Fermenter (2-L capacity) was 4.8 and 5.1 units for B. theobromae and R. oryzae, respectively using CSR as the carbon substrate. It is concluded that CSR, a cheap agricultural waste obtained after starch extraction from cassava could replace soluble starch as carbon substrate for commercial production of fungal amylase(s).     

Postnatal confirmation of prenatally diagnosed trisomy 16 mosaicism in two phenotypically abnormal liveborns

Two phenotypically abnormal liveborns in whom trisomy 16 mosaicism was diagnosed prenatally by amniocentesis are described. Analysis of a percutaneous umbilical blood sample in one case revealed a normal chromosomal complement. Ultrasound examinations performed at the time of amniocentesis were normal. Serial sonography during the late second and third trimesters demonstrated progressive intrauterine growth retardation (IUGR) in both fetuses and a cardiac defect in one. At birth, both infants had dysmorphic features and multiple congenital anomalies. Trisomy 16 mosaicism was confirmed postnatally in both infants in skin fibroblasts; however, peripheral blood samples contained only chromosomally normal cells. The two mosaic trisomy 16 cases described in this report, together with the five confirmed cases reported previously, demonstrate the need for caution in the counselling of patients when trisomy 16 mosaicism is diagnosed prenatally in amniotic fluid samples. Such cases potentially can result in the birth of dysmorphic infants with significant birth defects, growth retardation, and possible developmental disabilities.     

Transition Pathways to Sustainable Agricultural Water Management: A Review of Integrated Modeling Approaches

Agricultural water management (AWM) is an interdisciplinary concern, cutting across traditional domains such as agronomy, climatology, geology, economics, and sociology. Each of these disciplines has developed numerous process‐based and empirical models for AWM. However, models that simulate all major hydrologic, water quality, and crop growth processes in agricultural systems are still lacking. As computers become more powerful, more researchers are choosing to integrate existing models to account for these major processes rather than building new cross‐disciplinary models. Model integration carries the hope that, as in a real system, the sum of the model will be greater than the parts. However, models based upon simplified and unrealistic assumptions of physical or empirical processes can generate misleading results which are not useful for informing policy. In this article, we use literature and case studies from the High Plains Aquifer and Southeastern United States regions to elucidate the challenges and opportunities associated with integrated modeling for AWM and recommend conditions in which to use integrated models. Additionally, we examine the potential contributions of integrated modeling to AWM — the actual practice of conserving water while maximizing productivity. Editor's note : This paper is part of the featured series on Optimizing Ogallala Aquifer Water Use to Sustain Food Systems. See the February 2019 issue for the introduction and background to the series.     

Potentially preventable prehospital deaths from motor vehicle collisions

Background: In 2011, about 30,000 people died in motor vehicle collisions (MVCs) in the United States. We sought to evaluate the causes of prehospital deaths related to MVCs and to assess whether these deaths were potentially preventable.

Methods: Miami–Dade Medical Examiner records for 2011 were reviewed for all prehospital deaths of occupants of 4-wheeled motor vehicle collisions. Injuries were categorized by affected organ and anatomic location of the body. Cases were reviewed by a panel of 2 trauma surgeons to determine cause of death and whether the death was potentially preventable. Time to death and hospital arrival times were determined using the Fatality Analysis Reporting System (FARS) data from 2002 to 2012, which allowed comparison of our local data to national prevalence estimates.

Results: Local data revealed that 39% of the 98 deaths reviewed were potentially preventable (PPD). Significantly more patients with PPD had neurotrauma as a cause of death compared to those with a nonpreventable death (NPD) (44.7% vs. 25.0%, P =.049). NPDs were significantly more likely to have combined neurotrauma and hemorrhage as cause of death compared to PPDs (45.0% vs. 10.5%, P <.001). NPDs were significantly more likely to have injuries to the chest, pelvis, or spine. NPDs also had significantly more injuries to the following organ systems: lung, cardiac, and vascular chest (all P <.05). In the nationally representative FARS data from 2002 to 2012, 30% of deaths occurred on scene and another 32% occurred within 1 h of injury. When comparing the 2011 FARS data for Miami–Dade to the remainder of the United States in that year, percentage of deaths when reported on scene (25 vs. 23%, respectively) and within 1 h of injury (35 vs. 32%, respectively) were similar.

Conclusions: Nationally, FARS data demonstrated that two thirds of all MVC deaths occurred within 1 h of injury. Over a third of prehospital MVC deaths were potentially preventable in our local sample. By examining injury patterns in PPDs, targeted intervention may be initiated.     

Bacterial diversity in mining and non-mining regions with emphasis on plant growth-promoting traits

A total of 20 soil samples were collected from mining and non-mining areas of coal field regions of Dhanbad, India. These samples were grown on different types of selective media and a total of 141 isolates, each having plant growth-promoting (PGP) characteristics were obtained. The isolates were further tested for PGP traits (phosphate solubilisation, production of indole acetic acid, hydrogen cyanide, ammonia and siderophores) and a biochemical analysis was done to determine the prevalent species of the region. All the strains selected showed at least two PGP characteristics, which indicated that they can be used as plant growth promoters. Bacillus and Pseudomonas species were prevalent in both mining and non-mining areas, whereas Rhizobium, Azospirillum and Azotobacter were found mostly in the non-mining area. A total of 48 Bacillus, 29 Pseudomonas, 4 Rhizobium, 11 Azospirillum and 10 Azotobacter species were obtained from the two selected regions. The soil samples from the mining region were poor in nutrient content and thus relatively lower numbers of PGP isolates were attained.