Assessment and management of fetal agenesis of the corpus callosum

Prenatal counselling for fetal agenesis of the corpus callosum is difficult as the prognosis until now has been so uncertain. We have reviewed the current world English literature to provide the best probabilistic information for prospective parents. In total, there are 70 cases where the diagnosis was made prenatally. The diagnosis of apparently isolated agenesis of the corpus callosum (in the absence of other sonographically detectable anomalies) appears to carry an excellent prognosis, with an 85 per cent chance of a normal developmental outcome and a 15 per cent risk of handicap. Fetal karyotyping is recommended as there is a 1 in 10 risk of aneuploidy. If other anomalies are detected prenatally, the outcome is very poor. Termination of pregnancy is advised in these circumstances.     

The application of life cycle assessment to design

This paper explores the practical application of life cycle assessment (LCA) to product system development. While life cycle assessment methods have been studied and demonstrated extensively over the last two decades, their application to product design and development has not been critically addressed. Many organizational and operational factors limit the integration of the three LCA components (inventory analysis, impact assessment and improvement assessment) with product development. Design of the product system can be considered a synthesis of individual decisions and choices made by the design team, which ultimately shape the system's environmental profile. The environmental goal of life cycle design is to minimize the aggregate environmental impacts associated with the product system. Appropriate environmental information must be supplied to decision makers throughout each stage of the development process to achieve this goal. LCA can serve as a source of this information, but informational requirements can vary as the design moves from its conceptual phase, where many design choices are possible, to its detailed design and implementation. Streamlined approaches and other tools, such as design checklists, are essential. The practical use of this tool in product development also depends on the nature and complexity of the product system (e.g. new vs. established), the product development cycle (time-to-market constraints), availability of technical and financial resources, and the design approach (integrated vs. serial). These factors will influence the role and scope of LCA in product development. Effective communication and evaluation of environmental information and the integration of this information with cost, performance, cultural and legal criteria will also be critical to the success of design initiatives based on the life cycle framework. An overview of several of these design initiatives will be presented.     

Developing Canada's National Forest Carbon Monitoring, Accounting and Reporting System to Meet the Reporting Requirements of the Kyoto Protocol

The rate of carbon accumulation in the atmosphere can be reduced by decreasing emissions from the burning of fossil fuels and by increasing the net uptake (or reducing the net loss) of carbon in terrestrial (and aquatic) ecosystems. The Kyoto Protocol addresses both the release and uptake of carbon. Canada is developing a National Forest Carbon Monitoring, Accounting and Reporting System in support of its international obligations to report greenhouse gas sources and sinks. This system employs forest-inventory data, growth and yield information, and statistics on natural disturbances, management actions and land-use change to estimate forest carbon stocks, changes in carbon stocks, and emissions of non-CO₂ greenhouse gases. A key component of the system is the Carbon Budget Model of the Canadian Forest Sector (CBM-CFS). The model is undergoing extensive revisions to enable analyses at four spatial scales (national, provincial, forest management unit and stand) and in annual time steps. The model and the supporting databases can be used to assess carbon-stock changes between 1990 and the present, and to predict future carbon-stock changes based on scenarios of future disturbance rates and management actions.