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641.
J. Caspar Rüegg 《Die Naturwissenschaften》1998,85(12):575-582
2+ concentrations tropomyosin is located at the edge of the thin filament, thereby interfering with the formation of strong
actin-myosin linkages (blocked state). An increase in Ca2+ activity causes an azimuthal shift of tropomyosin around the filament (by about 30°), thereby increasing the probability
of low-force crossbridge interaction, a process which by cooperative effects induces further tropomyosin movement (by an additional
10°) which results in the open state of the filament characterized by forceful crossbridge interaction. (This mechanism may
be analogous to that in ligand-gated ion channels, where ligand binding increases the open probability of the pore.) The extent
of activation then depends on the free Ca2+ concentration and on the calcium sensitivity of the thin filament that may be affected by protein phosphorylation, crossbridge
attachment, the troponin isoform composition of the filament, and novel calcium-sensitizing drugs that act on the contractile
or regulatory proteins and thus increase the force of the heart. 相似文献
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645.
Mitigation and Adaptation Strategies for Global Change - Guidelines of the Intergovernmental Panel on Climate Change (IPCC) were used to assess a greenhouse gas inventory for land use change and... 相似文献
646.
647.
Flavonoid wing pigments increase attractiveness of female common blue (Polyommatus icarus) butterflies to mate-searching males 总被引:1,自引:0,他引:1
Common blue butterflies (Polyommatus icarus) sequester flavonoids from their larval host plants and allocate these UV-absorbing pigments to the wings. In field experiments
using dummies constructed from female butterflies, mate-searching males inspected flavonoid-rich dummies more intensively
than those with little or no flavonoids. Flavonoid content as signalled by UV-wing pattern may indicate ontogenetically determined
female quality or enhance detectability to males.
Received: 21 March 2000 / Accepted in revised form: 17 May 2000 相似文献
648.
The groundwater regime in Upper Palar basin, Tamilnadu has been highly contaminated in several locations due to discharge of effluents from a large number of tanneries. At some places total dissolved solids (TDS) concentration in groundwater was found as high as 8000 mg/l. Transmissivity and storativity of the regional aquifer were estimated at a few locations. The porosity and dispersivity values were not determined in the field. These parameters were assumed based on data available for similar geological formations elsewhere. The aquifer conceptualization thus arrived at formed the basis of a numerical groundwater flow model which was constructed using the finite difference method. The flow model was calibrated for steady state and then for transient condition for the period of 1984-92. The computed heads and calibrated parameters of the flow model were used to compute groundwater velocities. The migration of contaminants for a 20 year period was computed using the hydraulic heads and effective porosity value in a pathline model using FLOWPATH software. Mass transport model was constructed using Method of Characteristics (MOC) computer code in a separate model. The seepage rate of effluent is assumed at a rate of 30% of that discharged on the surface. The mass concentration of solute in the effluent reaching the water table was assumed as 40%, the same as in the surface effluent. The mass transport model was calibrated for a 20 year period. Prediction of contaminant migration from different clusters in the basin was analyzed. The prediction results indicated elevated TDS concentration of more than 4000 mg/l from most clusters. Also the area of the contaminated zone is likely to double in 20 years from contaminated zone of 1992. 相似文献
649.
Arachnoid cysts are an uncommon central nervous system malformation, representing only 1 per cent of all intracranial masses. We report the second-trimester prenatal diagnosis of a posterior fossa arachnoid cyst, associated with an unbalanced X;9 translocation. 相似文献
650.
Yun-Ling Zheng Maryann Demaria Dongkai Zhen Theresa J. Vadnais Diana W. Bianchi MD 《黑龙江环境通报》1995,15(10):897-905
Monoclonal antibody to fetal haemoglobin (a2γy2) has been proposed as a fetal-specific reagent. We developed an intracellular staining protocol that combines fluorescein isothiocyanate or phycoerythrin conjugated anti-γ with the DNA binding dye Hoechst 33342 to identify and flow sort fetal erythroblasts from maternal blood. Our preliminary observations on anti-γ-positive cells sorted from four different pregnant women are described here, using fluorescence in situ hybridization (FISH) with chromosome-specific probes to identify fetal cells. Our data demonstrate that far fewer candidate fetal cells are sorted with this protocol than by current cell surface staining methods that employ the monoclonal antibody CD71. This results in increased fetal cell sorting purities. With this protocol, standard FISH techniques require modification due to the rigorous fixation with 4 per cent paraformaldehyde. Our initial data indicate the promise of this approach. 相似文献