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181.
Shweta Paroha Arvind K. Singh Chandel Ravindra Dhar Dubey 《Environmental Chemistry Letters》2018,16(1):71-77
Coenzyme Q10 is an antioxidant present in the human body. Coenzyme Q10 has an essential role in various biochemical reactions. The deficiency of coenzyme Q10 in the body leads to disorders including neurological degeneration, ageing and cancer. Clinical trials have tested coenzyme Q10 as a drug or a dietary supplement. However, the major pharmaceutical issue of coenzyme Q10 delivery is its high molecular weight and poor water solubility. This limitation leads to its poor oral bioavailability. Several methods have been designed to overcome the poor water solubility of coenzyme Q10, such as size reduction and ionization. This article presents nanotechnology-based drug delivery systems for coenzyme Q10 with special emphasis on pharmacokinetic perspectives and clinical relevance. Systems include nanoparticles, solid dispersions, liposomes, nanoemulsions, self-emulsifying drug delivery systems, nanostructured lipid carriers, cyclodextrins and nanocapsules. 相似文献
182.
Atul K. Singh Sharad C. Srivastava Pankaj Verma Abubakar Ansari Ambrish Verma 《Environmental monitoring and assessment》2014,186(6):3823-3836
Monitoring of heavy metals was conducted in the Yamuna River considering bioaccumulation factor, exposure concentration, and human health implications which showed contamination levels of copper (Cu), lead (Pb), nickel (Ni), and chromium (Cr) and their dispersion patterns along the river. Largest concentration of Pb in river water was 392 μg L?1; Cu was 392 μg L?1 at the extreme downstream, Allahabad and Ni was 146 μg L?1 at midstream, Agra. Largest concentration of Cu was 617 μg kg?1, Ni 1,621 μg kg?1 at midstream while Pb was 1,214 μg kg?1 at Allahabad in surface sediment. The bioconcentration of Cu, Pb, Ni, and Cr was observed where the largest accumulation of Pb was 2.29 μg kg?1 in Oreochromis niloticus and 1.55 μg kg?1 in Cyprinus carpio invaded at Allahabad while largest concentration of Ni was 174 μg kg?1 in O. niloticus and 124 μg kg?1 in C. carpio in the midstream of the river. The calculated values of hazard index (HI) for Pb was found more than one which indicated human health concern. Carcinogenic risk value for Ni was again high i.e., 17.02?×?10?4 which was larger than all other metals studied. The results of this study indicated bioconcentration in fish due to their exposures to heavy metals from different routes which had human health risk implications. Thus, regular environmental monitoring of heavy metal contamination in fish is advocated for assessing food safety since health risk may be associated with the consumption of fish contaminated through exposure to a degraded environment. 相似文献
183.
Smriti Sharma Balwinder Singh V. K. Gupta 《Environmental monitoring and assessment》2014,186(11):7183-7193
Imidacloprid is extensively used on a broad range of crops worldwide as seed dressing, soil treatment, and foliar application. Hence, the degradation potential of bacterial strains from sugarcane-growing soils was studied in liquid medium for subsequent use in bioremediation of contaminated soils. The microbe cultures degrading imidacloprid were isolated and enriched on Dorn’s broth containing imidacloprid as sole carbon source maintained at 28 °C and Bacillus alkalinitrilicus showed maximum potential to degrade imidacloprid. Clay loam soil samples were fortified with imidacloprid at 50, 100, and 150 mg kg?1 along with 45?×?107 microbe cells under two opposing sets of conditions, viz., autoclaved and unautoclaved. To study degradation and metabolism of imidacloprid under these two conditions, samples were drawn at regular intervals of 7, 14, 28, 35, 42, 49, and 56 days. Among metabolites, three metabolites were detected, viz., 6-chloronicotinic acid, nitrosimine followed by imidacloprid-NTG under both the conditions. Total imidacloprid residues were not found to follow the first-order kinetics in both types of conditions. This paper reports for the first time the potential use of pure cultures of soil-isolated native bacterium B. alkalinitrilicus and also its use along with natural soil microflora for remediation of imidacloprid-contaminated soils. 相似文献
184.
A. V. M. Subba Rao Arun K. Shanker V. U. M. Rao V. Narsimha Rao A. K. Singh Pragyan Kumari C. B. Singh Praveen Kumar Verma P. Vijaya Kumar B. Bapuji Rao Rajkumar Dhakar M. A. Sarath Chandran C. V. Naidu J. L. Chaudhary Ch. Srinivasa Rao B. Venkateshwarlu 《Environmental Modeling and Assessment》2016,21(1):17-30
185.
Rai Singh Bhupender S. Sharma Shiv Nath Chalka 《Environmental monitoring and assessment》2010,168(1-4):195-203
Atmospheric aerosols and their impacts on the environment particularly on human health is an issue of significant public and governmental concern. Though studies on air quality related to total suspended particulate matter have done by various authors in India, yet respirable suspended particulate matter (PM10) is not characterized so far particularly in a historical and world heritage city like Agra. This study presents seasonal variation in mass levels of PM10 and its ionic composition. PM10 samples were collected in the proximity of Taj Mahal and subjected to chemical analysis using ion chromatography technique. The preliminary findings reveal that the 24-h average of PM10 mass level varies from 115 to 233, 155 to 321, and 33 to 178 μg/m3, respectively, in summer, winter, and rainy seasons indicating critical pollution situation. These values are very much higher than the National Ambient Air Quality Standards of 75 μg/m3 (prescribed by Central Pollution Control Board, India) in both of summer and winter seasons whereas quite near the permissible limits in rainy season. The equivalent ratios of NH4 + to nonsea salt SO4 2? and NO3 ? and ∑Cations to ∑Anios were found to be greater than unity indicating high source strength of ammonia and alkaline nature of aerosols. The study suggests the need for continuous and long-term systematical sampling and detailed physiochemical analysis of PM10 and also to know the characteristics of PM in background areas for better understanding of the emission sources. 相似文献
186.
High quality habitat suitability maps are indispensable for the management and planning of wildlife reserves. This is particularly important for megadiverse developing countries where shortages in skilled manpower and funding may preclude the use of mathematically complex modeling techniques and resource-intensive field surveys. In this study, we propose a simulation based k-fold partitioning and re-substitution approach to refine and update logistic regression models that are widely used for habitat suitability assessment and modeling. We test the modeling strategy using data from a rapid field survey conducted for habitat suitability assessment for muntjak (Muntiacus muntjak) and goral (Naemorrhaedus goral) in the central Himalayas, India. Results obtained from simulations match expectations in terms of model behavior and in terms of published habitat associations of the investigated species. Qualitative comparisons with predictions from the GARP, MaxEnt and Bioclimatic Envelopes modeling systems also show broad agreement with predictions obtained from the proposed technique. The proposed technique is suggested as a rapid-assessment precursor to detailed habitat studies such as patch occupancy modeling in situations where funds or trained manpower are not available. 相似文献
187.
Bansal SK Singh KV Sharma S Sherwani MR 《Journal of environmental biology / Academy of Environmental Biology, India》2011,32(1):71-75
Larvicidal potential of the extracts from different parts viz. green and red fruits, seeds, fruit without seeds, leaves and roots of Withania somnifera in different solvents was evaluated against larvae of Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus, the important disease vectors prevalent in the semi-arid region. Experiments were carried out on late 3rd or early 4th instar larvae of these mosquitoes using standard WHO technique. 24 and 48 hr LC50 values along with their 95% confidence limits, regression equation, chi-square (chi2)/heterogeneity of the response have been determined by log probit regression analysis. The 24 hr LC50 values as observed for whole green fruits in water, methanol and petroleum ether were 350.9, 372.4, 576.9; 115.0, 197.1, 554.6; 154.9, 312.0, 1085.0 while corresponding values for red fruits were 473.5, 406.4,445.2; 94.7, 94.5, 1013.0; 241.8, 535.0, 893.3 mg l(-1) for An. stephensi, Ae. aegypti and Cx. quinquefasciatus respectively showing that methanol extracts were more effective against anophelines as compared to culicines when whole fruits were taken. The 24 hr LC50 values as observed for seeds in acetone, methanol and petroleum ether were 188.1, 777.5, 822.5; 245.5, 769.0, 1169.0; 140.3, 822.9, 778.4 and for fruit without seeds were 80.2, 97.6, 146.6; 88.4, 404.4, 1030.0; 30.0, 44.5, 54.2 mg l(-1) for the above mosquito species respectively showing that extract of fruit without seeds were most effective in petroleum ether followed by acetone and methanol extracts. However, experiments conducted with methanol extracts of leaves and roots of this plant species did not show any appreciable larvicidal activity and a 20-40% mortality was observed up to 500 mg l(-1) of the extracts. Overall larvae of anophelines were found more susceptible as compared to culicines to all the extracts tested. Petroleum ether extract of fruit without seeds was found most effective against all the mosquito species showing that active ingredient might be present in this part of the plant species. The study would be of great importance while planning vector control strategy based on alternative plant derived insecticides. 相似文献
188.
Singh VK Pathak MK Bihari V Jyoti Patel DK Mathur N Kesavachandran CN Siddiqui MK 《Journal of environmental biology / Academy of Environmental Biology, India》2011,32(1):39-42
An important role of oxidative stress for the development of vascular and neurological complications has encouraged us to undertake a study to assess the oxidative stress induced nerve conduction deficits among cigarette smokers. Eighteen regular male cigarette smokers and twenty nine male non-smokers were diagnosed for clinical neuro-physiological tests viz., motor and sensory nerve conduction velocity (MNCV and SNCV) and redox status. Significant depletion of reduced glutathione (GSH) level (p < 0.05) and significant increase in malondialdehyde (MDA) level (p < 0.01) was found in smokers compared to non-smokers. Motor and sensory nerve conduction velocity showed no significant difference among smokers compared to non-smokers. The present study shows that smoking can induce oxidative stress among smokers but could not exacerbate to nerve conduction deficits. 相似文献
189.
Chaudhary P Singh SB Chaudhry S Nain L 《Environmental monitoring and assessment》2012,184(2):1145-1156
The present study is aimed at analysing and comparing different soil enzymes in soil samples of native contaminated sites
of a Mathura refinery and adjoining agricultural land. Enzyme activities are considered as indicators of soil quality and
changes in biogeochemical function due to management or perturbations. Soil samples were collected from the premises and nearby
area of Mathura refinery, India. Biological health parameters (dehydrogenase, aryl esterase, aryl sulphatase,
\upbeta \upbeta -glucosidase, alkaline phosphatase, acid phosphatase, lipase, laccase and catalase activity) were estimated in the soil samples.
Among all the samples, sewage sludge soil showed maximum activity of enzymes, microbial biomass carbon and most probable number
of polycyclic aromatic hydrocarbon (PAH) degraders in soils spiked with three- to four-ring PAHs at 50 ppm. Available phosphorus,
potassium and nitrogen was also exceptionally high in this sample, indicating maximum microbial bioconversion due to presence
of nutrients stimulating potent PAH-degrading microorganisms. 相似文献
190.
The activity concentrations of soil samples collected from thirty different locations of Malwa region of Punjab were determined
by using HPGe detector based on high-resolution gamma spectrometry system. The range of activity concentrations of 226Ra, 232Th and 40K in the soil from the studied areas varies from 18.37 Bq kg−1 (Sangrur) to 53.11 Bq kg−1 (Sitoguno), 57.28 Bq kg−1 (Dhanola) to 148.28 Bq kg−1 (Sitoguno) and 211.13 Bq kg−1 (Sunam) to 413.27 Bq kg−1 (Virk Khera) with overall mean values of 35 Bq kg−1, 80 Bq kg−1and 317 Bq kg−1 respectively. The absorbed dose rate calculated from activity concentration of 226Ra, 232Th and 40K ranges between 8.47 and 24.48, 35.68 and 92.38, and 8.74 and 17.11 nGy h−1, respectively. The total absorbed dose in the study area ranges from 58.08 nGy h−1 to 130.85 nGy h−1 with an average value of 79.11 nGy h−1. The calculated values of external hazard index (Hex) for the soil samples of the study area range from 0.35 to 0.79. Since these values are lower than unity, therefore, according
to the Radiation Protection 112 (European Commission. Radiation Protection 112 1999) report, soil from these regions is safe and can be used as a construction material without posing any significant radiological
threat to population. 相似文献