Kolaviron suppresses dysfunctional reproductive axis associated with multi-walled carbon nanotubes exposure in male rats

Reproductive toxicity associated with excessive exposure to multi-walled carbon nanotubes (MWCNTs), which are commonly used in medicine as valuable drug delivery systems, is well documented. Kolaviron, a bioflavonoid isolated from Garcinia kola seeds, elicits numerous health beneficial effects related to its anti-inflammatory, anti-genotoxic activities, anti-apoptotic, and antioxidant properties. However, information on the role of kolaviron in MWCNTs-induced reproductive toxicity is not available in the literature. Herein, we assessed the protective effects of kolaviron on MWCNTs-induced dysfunctional reproductive axis in rats following exposure to MWCNTs (1 mg/kg) and concurrent treatment with kolaviron (50 or 100 mg/kg body weight) for 15 successive days. Results showed that MWCNTs-induced dysfunctional reproductive axis as evidenced by deficits in pituitary and testicular hormones, marker enzymes of testicular function, and sperm functional characteristics were abrogated in rats co-administered with kolaviron. Moreover, co-administration of kolaviron-abated MWCNTs-induced inhibition of antioxidant enzyme activities increases in oxidative stress and inflammatory indices. This is evidenced by diminished levels of tumor necrosis factor-alpha, nitric oxide, lipid peroxidation, reactive oxygen, and nitrogen species as well as reduced activity of myeloperoxidase in testes, epididymis, and hypothalamus of the rats. Biochemical data on the chemoprotection of MWCNTs-induced reproductive toxicity were corroborated by histological findings. Taken together, kolaviron suppressed dysfunctional reproductive axis associated with MWCNTs exposure via abrogation of oxidative stress and inflammation in male rats.

     

Epidemiology and patterns of facial fractures due to road traffic accidents in Taiwan: A 15-year retrospective study

Objective: The facial region is a commonly fractured site, but the etiology varies widely by country and geographic region. To date, there are no population-based studies of facial fractures in Taiwan.

Methods: We conducted a retrospective study of patients diagnosed with facial fracture and registered in the National Health Insurance Research Database of Taiwan between 1997 and 2011. The epidemiological characteristics of this cohort were analyzed, including the etiology, fracture site, associated injuries, and sex and age distributions.

Results: A total of 6,013 cases were identified that involved facial fractures. Most patients were male (69.8%), aged 18–29 years (35.8%), and had fractures caused by road traffic accidents (RTAs; 55.2%), particularly motorcycle accidents (31.5%). Falls increased in frequency with advancing age, reaching 23.9% among the elderly (age > 65 years). The most common sites of involvement were the malar and maxillary bones (54.0%), but nasal bone fractures were more common among those younger than 18 years.

Conclusion: Most facial injuries in Taiwan occur in young males and typically result from RTAs, particularly involving motorcycles. However, with increasing age, there is an increase in the proportion of facial injuries due to falls.     

In vitro dissolution studies of uranium bearing material in simulated lung fluid

Inhaled uranium (U) bearing material will partially dissolve in the fluid lining of the lung, followed by a combination of retention, re-distribution, and excretion of the U. The rate of dissolution influences the retention time at the site of deposition, and the extent to which the material is available for re-distribution to other tissues. The consequential radiation dose is dependent upon the material distribution in the body and the exposure time to various tissues. The International Commission on Radiological Protection, ICRP 66 [International Commission on Radiological Protection (ICRP), 1994. Human Respiratory Tract Model for Radiological Protection. ICRP Publication 66] recommends the use of experimentally determined solubility coefficients in dose modelling. Material specific absorption parameters allow for better dose estimation than using ICRP default values for F (fast), M (moderate) and S (slow) classifications of U compounds. In vitro dissolution tests were carried out on U material collected from two U mines located in Australia. A static technique was designed in which particle samples were sandwiched between two 0.1-mum pore size membrane filters. The filter sandwich was exposed to a solvent (simulated lung fluid) for selected time intervals, at controlled test conditions for temperature and pH. The collected solution was analysed for U concentration using ICP-MS. The resulting dissolution curves were fitted with a double or triple exponential equation to determine the dissolution coefficients.     

Options for water storage and rainwater harvesting to improve health and resilience against climate change in Africa

West and East Africa experience high variability of rainfall that is expected to increase with climate change. This results in fluctuations in water availability for food production and other socioeconomic activities. Water harvesting and storage can mitigate the adverse effects of rainfall variability. But past studies have shown that when investments in water storage are not guided by environmental health considerations, the increased availability of open water surface may increase the transmission of water-related diseases. This is demonstrated for schistosomiasis associated with small reservoirs in Burkina Faso, and for malaria in Ethiopia around large dams, small dams, and water harvesting ponds. The concern is that the rush to develop water harvesting and storage for climate change adaptation may increase the risk for already vulnerable people, in some cases more than canceling out the benefits of greater water availability. Taking health issues into account in a participatory approach to planning, design, and management of rainwater harvesting and water storage, as well as considering the full range of water storage options would enable better opportunities for enhancing resilience against climate change in vulnerable populations in sub-Saharan Africa.     

Predicting copper concentrations in acid mine drainage: a comparative analysis of five machine learning techniques

Acid mine drainage (AMD) is a global problem that may have serious human health and environmental implications. Laboratory and field tests are commonly used for predicting AMD, however, this is challenging since its formation varies from site-to-site for a number of reasons. Furthermore, these tests are often conducted at small-scale over a short period of time. Subsequently, extrapolation of these results into large-scale setting of mine sites introduce huge uncertainties for decision-makers. This study presents machine learning techniques to develop models to predict AMD quality using historical monitoring data of a mine site. The machine learning techniques explored in this study include artificial neural networks (ANN), support vector machine with polynomial (SVM-Poly) and radial base function (SVM-RBF) kernels, model tree (M5P), and K-nearest neighbors (K-NN). Input variables (physico-chemical parameters) that influence drainage dynamics are identified and used to develop models to predict copper concentrations. For these selected techniques, the predictive accuracy and uncertainty were evaluated based on different statistical measures. The results showed that SVM-Poly performed best, followed by the SVM-RBF, ANN, M5P, and KNN techniques. Overall, this study demonstrates that the machine learning techniques are promising tools for predicting AMD quality.     

Cattle-rangeland management practices and perceptions of pastoralists towards rangeland degradation in the Borana zone of southern Ethiopia

A survey was conducted in the Borana pastoral areas of southern Ethiopia to assess current livestock production systems, rangeland management practices and the perceptions of the pastoralists towards rangeland degradation. This information is considered vital to future pastoral development planning and interventions. Data were collected from a total of 20 villages that were identified from 5 peasant associations, namely Did Yabello, Moyatte, Did Harra, Dubuluk and Melbana. The average household size in the study area was 7.23. The majority of the pastoralists relied on both livestock and crop farming. The average livestock holding per household was 14 cattle, 10 goats, 6 sheep and 2 camels. Livestock holdings, with the exception of camels, has shown a declining trend over time. The two most important traditional rangeland management strategies adopted by the pastoralists included burning and mobility, but since 1974/75 burning has no longer been practised. With regard to mobility, the livestock herding falls in two categories, namely: home based and satellite herding. The former involves the herding of milking cows, calves and immature animals (<2 years) close to the encampments. The latter constitutes the herding of bulls and immatures (>2 years) further away from the encampments. Based on the pastoralists' perceptions, the major constraints on livestock production in descending order, were recurrent drought, feed and water scarcity, animal diseases, predators and communal land ownership. All the respondents considered the condition of the rangelands to have declined dramatically over time. In the past most development policies were based on equilibrium theories that opposed the communal use of the rangelands and traditional range management practices. The way in which the pastoral system affects the rangeland ecosystem functioning is contentious to this theory and the 'tragedy of the commons'. There was also a perceived problem of bush encroachment and the ban on traditional burning practices and recurrent droughts were seen as aggravating factors to this invasion process. The increasing practice of crop cultivation on the rangelands was identified as a serious threat to future livestock production and traditional resource management practices. Suggestions for possible interventions to improve the productivity and sustainable use of these rangelands are made.     

Rangeland dynamics in southern Ethiopia: (1) botanical composition of grasses and soil characteristics in relation to land-use and distance from water in semi-arid Borana rangelands

The distribution and compositional pattern of the grass layer, as well as soil quality of southern Ethiopian semi-arid rangelands were examined under three land-use systems (communal land, government ranch and a traditional grazing reserve enclosure) and along a distance gradient (near, middle and far) from water sources. In total, 49 grass species were identified, 65% of which were perennials. Of the most commonly distributed highly desirable species, Chrysopogon aucheri showed the greatest frequency under the traditional grazing reserve (27.6%), and the lowest in the communal land (14.0%). The frequency of Cenchrus ciliaris was similar in all the study sites. The proportion of Lepthotrium senegalensis was low under the land-use systems (3.9%) and increased away from water sources (2.3%). Of the less desirable species, Sporobulus nervosus was extremely more abundant (<0.05) in the communal land (13.3%) than the traditional grazing reserve (3.3%) and the government ranch (1.9%). Sporobolus pyramidalis was dominant in the study sites, with similar (P>0.05) frequency percentages under the land-use systems and along the distance gradients from water. Basal cover was low and similar on all the study sites (3.3%). Concerning the soil texture, sand (71.1%) constituted the largest proportion, followed by silt (21.3%) and lastly, clay (7.7%). With regard to soil exchangeable cations, organic C and total nitrogen were generally low and did not show marked variation in all the study sites. The study showed significant differences for most of the vegetation variables between the communal land and the other land-uses. This suggested that grazing intensity was higher in the communal land and moderate in the government ranch and in the traditional grazing reserves (kallos). The lack of significant differences in most of the studied (vegetation) variables along the distance gradient from water could be ascribed to the fact that grazing disturbance has already exceeded a certain threshold of degradation. Under the present low states of soil nutrients and rainfall, cultivation is neither sustainable nor environmentally friendly and this will lead to further degradation of the soil in these marginal lands.     

Short-term temporal variation in PM2.5 mass and chemical composition during the Atlanta Supersite Experiment, 1999

Measurements in urban Atlanta of transient aerosol events in which PM2.5 mass concentrations rapidly rise and fall over a period of 3-6 hr are reported. The data are based on new measurement techniques demonstrated at the U.S. Environmental Protection Agency (EPA) Atlanta Supersite Experiment in August 1999. These independent instruments for aerosol chemical speciation of NO3-, SO4(2-), NH4+, and organic and elemental carbon (OC and EC), reconstructed the observed hourly dry PM2.5 mass to within 20% or better. Data from the experiment indicated that transient PM2.5 events were ubiquitous in Atlanta and were typically characterized by a sudden increase of EC (soot) and OC in the early morning or SO4(2-) in the late afternoon. The frequent temporal decoupling of these events provides insights into their origins, suggesting mobile sources in metro Atlanta as the main contributor to early morning PM2.5 and more regionally located point SO2 sources for afternoon PM2.5 events. The transient events may also have health implications. New data suggest that short-term PM2.5 exposures may lead to adverse health effects. Standard integrated filter-based techniques used in PM2.5 compliance monitoring networks and in most past PM2.5 epidemiologic studies collect samples over 24-hr periods and thus are unable to capture these transient events. Moreover, health-effects studies that focus on daily PM2.5 mass alone cannot evaluate the health implications of the unique and variable chemical properties of these episodes.