Metaphyseal chondrodysplasia McKusick type in a Chinese fetus,caused by novel compound heterozygosity 64T> A and 79G >T in RMRPgene

We present the first confirmed case by molecular analysis of a metaphyseal chondrodysplasia, McKusick type, in a 22-week fetus. Two novel compound heterozygous mutations, 64T> A and 79G > T, were found in the highly conserved regions of the RMRP gene. Twenty-two heterozygous g.1018 T> C mutations, two homozygous g.1018 T> C mutations, two heterozygous insertion mutations g.799_g.800insC and one heterozygous insertion mutation g.849_g.850insT were found among 100 normal controls. Careful radiological examination of the fetus for skeletal dysplasia allowed definitive diagnosis, proper genetic counselling and future prenatal diagnosis. Copyright © 2006 John Wiley & Sons, Ltd.     

Resources policies in Australia

Developments in Australia's resource industries in recent years have raised policy issues not previously encountered, and their consideration has been superimposed onto traditional policies affecting resource production and use. This review of Australia's policies on resources - here meaning minerals and energy policies - looks at the objectives of these policies and their interrelationships. It considers issues such as management, development objectives, investment, taxation, environment and processing, and likely future developments.     

Tropical annual cropping systems: Ant ecology

The ecological role of ants in tropical annual cropping systems is discussed in general and with respect to a specific Mexican agroecosystem Generally, the potential positive contributions of ants to crop yields result from their impact on soil structure, nutrient cycling, and reduction of insect and weed pests In annual wet lowland fields in eastern Mexico, the ant community is simple and dominated by the aggressive fire ant,Solenopsis geminata. The influence of vegetation structure and composition on the ant community and, specifically, on the foraging behavior ofS geminata is discussed     

Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: Two-stage carcinogenesis in skin tumor sensitive mice (SENCAR)

Skin tumors can be induced by the sequential application of a subthreshold dose of a carcinogen (initiation phase), followed by repetitive treatment with a noncarcinogenic tumor promoter. There is a very good dose-response relationship between the induction of the number of papillomas per mouse at early times (10 to 20 weeks) by either tumor initiators and promoters and the final carcinoma incidence after a longer latency (20 to 50 weeks) in SENCAR mice. This system not only can be used to determine the tumor initiating and promoting activities of a compound but if the agent is given repeatedly by itself one can also determine if it is a complete carcinogen, i.e., if it has both tumor initiating and promoting activity. In addition, if the agent is given concurrently with a known complete carcinogen or a tumor initiator one can also determine if the agent has cocarcinogenic or cotumor initiating activity or even possibly anticarcinogenic activity. Likewise, if the agent is given concurrently with a known tumor promoter one can determine if the agent has copromoting or antipromoting activity. Using the SENCAR skin carcinogenesis system we have undertaken the determination of the skin carcinogenic, cocarcinogenic, tumor initiating and promoting activities of various diesel emission particle extracts as well as for comparative purposes, standards such as benzo(a)pyrene and 12-0-tetradecanoylphorbol-13-acetate and extracts of emissions from a gasoline engine, roofing tar, coke oven and cigarette smoke condensate. Most of the studies are still in progress but some preliminary data is available on the comparative tumor initiating activities of the various samples at 14 weeks. Caterpillar diesel and cigarette smoke condensate were essentially without activity, whereas the Mustang gasoline catalyst and Olds diesel gave extremely low values although they were slightly above background. Roofing tar, coke oven and Nissan Diesel all gave moderate activity at high doses (1 to 10 mg) but when compared to benzo(a)pyrene were relatively low values.     

Does the preferential microbial colonisation of ferromagnesian minerals affect mineral weathering in soil?

Fungal activity is thought to play a direct and effective role in the breakdown and dissolution of primary minerals and in the synthesis of clay minerals in soil environments, with important consequences for plant growth and ecosystem functioning. We have studied primary mineral weathering in volcanic soils developed on trachydacite in southern Tuscany using a combination of qualitative and quantitative mineralogical and microbiological techniques. Specifically, we characterized the weathering and microbiological colonization of the magnetically separated ferromagnesian minerals (biotite and orthopyroxene) and non-ferromagnesian constituents (K-feldspar and volcanic glass) of the coarse sand fraction (250-1,000 microm). Our results show that in the basal horizons of the soils, the ferromagnesian minerals are much more intensively colonized by microorganisms than K-feldspar and glass, but that the composition of the microbial communities living on the two mineral fractions is similar. Moreover, X-ray diffraction, optical and scanning electron microscope observations show that although the ferromagnesian minerals are preferentially associated with an embryonic form of the clay mineral halloysite, they are still relatively fresh. We interpret our results as indicating that in this instance microbial activity, and particularly fungal activity, has not been an effective agent of mineral weathering, that the association with clay minerals is indirect, and that fungal weathering of primary minerals may not be as important a source of plant nutrients as previously claimed.