A rare case of de novo structural rearrangement of X chromosome diagnosed by amniocentesis

A dicentric X chromosome was found in a female fetus during cytogenetic studies performed on amniotic cells. Blood samples from the parents showed normal karyotypes and the pregnancy was terminated. The mechanism for the formation of this ‘de novo’ rearrangement is discussed.     

First-trimester prenatal diagnosis of aspartylglucosaminuria

Fetal aspartylglucosaminuria (AGU) was studied during the first trimester of pregnancy in six at-risk pregnancies using chorionic villus samples. The activity of aspartylglucosaminidase (AGA) was high in five cases, indicating an unaffected fetus. This was confirmed through delivery of healthy newborns with a normal pattern of urinary oligosaccharides. Low enzyme activity in an uncultured biopsy specimen and in cultured amniotic fluid cells in one case demonstrated that the fetus was affected. The pregnancy was terminated and the prenatal diagnosis was confirmed by showing reduced AGA activity in cultured fibroblasts of the fetus.     

Carbon and nitrogen mineralization in Vertisol as mediated by type and placement method of residue

Selection of appropriate residue application method is essential for better use of biomass for soil and environmental health improvement. A laboratory incubation experiment was conducted for 75 days to investigate C and N mineralization of residues of soybean (Glycine max L.), chickpea (Cicer arietinum L.), maize (Zea mays L.), and wheat (Triticum aestivum L.) placed on the soil surface and incorporated into the soil. The residue of soybean and chickpea had a greater decomposition rate than that of maize and wheat, despite of their placements. Higher rate of decomposition of the residue of soybean and chickpea was recorded when it was kept on the soil surface while soil incorporation of residue of wheat and maize resulted in faster decomposition. Therefore, these findings could be used as guidelines for management of crop residue application in farmland to improve soil and environmental quality.     

Temporal variation in total phosphorus concentrations revealed from a multidecadal monitoring program on Big Platte Lake,Michigan

Effective water quality management depends on enactment of appropriately designed monitoring programs to reveal current and forecasted conditions. Because water quality conditions are influenced by numerous factors, commonly measured attributes such as total phosphorus (TP) can be highly temporally varying. For highly varying processes, monitoring programs should be long-term and periodic quantitative analyses are needed so that temporal trends can be distinguished from stochastic variation, which can yield insights into potential modifications to the program. Using generalized additive mixed modeling, we assessed temporal (yearly and monthly) trends and quantified other sources of variation (daily and subsampling) in TP concentrations from a multidecadal depth-specific monitoring program on Big Platte Lake, Michigan. Yearly TP concentrations decreased from the late 1980s to late 1990s before rebounding through the early 2000s. At depths of 2.29 to 13.72 m, TP concentrations have cycled around stationary points since the early 2000s, while at the surface and depths ≥?18.29 concentrations have continued declining. Summer and fall peaks in TP concentrations were observed at most depths, with the fall peak at deeper depths occurring 1 month earlier than shallower depths. Daily sampling variation (i.e., variation within a given month and year) was greatest at shallowest and deepest depths. Variation in subsamples collected from depth-specific water samples constituted a small fraction of total variation. Based on model results, cost-saving measures to consider for the monitoring program include reducing subsampling of depth-specific concentrations and reducing the number of sampling depths given observed consistencies across the program period.     

Validity and reliability of a job factors questionnaire related to the work tasks of physical therapists

Physical therapists engage in work tasks that expose them to occupational risk factors related to musculoskeletal disorders. Due to the gap in the literature on instruments focused on those workers, this study adapted a job factors questionnaire to physical therapists, and assessed its psychometric properties. The questionnaire was adapted and its content validity was established. The psychometric properties were evaluated among 142 physical therapists. Reliability was verified using the temporal-stability design and internal consistency. Construct validity was assessed with the known-groups technique. Test-retest results demonstrated intraclass correlation coefficients between .82 and .90 (p < .001). Cronbach's α of .91 verified the reliability of the questionnaire. The known-groups technique demonstrated a statistically significant difference on the scores of the items when physical therapists were compared to office workers. The results indicated that the adapted questionnaire had acceptable psychometric properties for assessing problematic job factors among physical therapists working in hospitals.     

Working conditions,psychological/physical symptoms and occupational accidents. Bayesian network models

Each day thousands of workers suffer occupational accidents of varying degrees of severity. Accidents at work render workers incapable of carrying out their day to day activities, either temporarily or permanently, and they also have detrimental effects on family life, the company, and the general public. In order to reduce the occupational accident rate, it is necessary to determine the causes of those accidents. Although there are many different types of accidents, they generally stem from poor working conditions. The purpose of this study was to analyze the influence of working conditions on occupational accidents from data gathered in the VI National Survey of Working Conditions (VI NSWCs) in 2007. This survey utilized a random sample of the active population of Spain. The sample comprised 11,054 people (5917 males and 5137 females). In order to carry out the study, a probabilistic model was built using Bayesian networks. The model included the following variables: hygiene conditions, ergonomic conditions, job demands, physical symptoms, psychological symptoms, and occupational accidents. The study demonstrated that there were strong relationships between hygiene conditions and occupational accidents; it has been shown that poor hygienic conditions duplicate the probability of accident. Physical symptoms increased almost 50% due to poor ergonomic conditions. And finally, high job demands almost duplicated the psychological symptoms. The investigation also showed a high degree of interdependence between physical and psychological symptomatologies and the relationship between these and occupational accidents.     

Representation of complex visual stimuli in the brain

A method was developed to investigate transfer properties of neurons in the visual system using pictures of complex visual stimuli. The picture is moved over the receptive field of a neuron so that it can scan it along programmed lines. The activity of the neuron during the scanning procedure is presented in a two-dimensional dot display on scale with the original picture. By superposition of the stimulus and the transfer pattern, one can find out to which detail of a stimulus the neuron responds. Neurons in the first intracerebral relay of the visual system, the lateral geniculate body, reduce a complex stimulus, such as a photograph of a natural environment, to its contours. Cortical cells only respond to contours either of a limited or of a wider range of orientations (simple and complex cells, respectively). But the course of contours is only described by a continuous representation of these contours in the cortical map of the visual field. This is done by the simple cells, which have small receptive fields and thus a higher resolving power, whereas complex cells with their large receptive fields monitor the approximate location of a moving stimulus. The function of these two classes of neurons is discussed in terms of visual behavior, i.e., for fixation, hold, and binocular vergence movements (simple cells), and for detection of moving objects and motor command signals towards these objects (complex cells). These functions are an important condition for foveal vision which is the basis of perception in primates. An important function of orientation sensitivity of simple cells may be the binocular alignment of contours in binocular fusion and stereoscopic vision.     

Silver sources of archaic Greek coinage

We report on new chemical and lead isotopic results and interpretations of archaic Greek silver coins from the Asyut hoard which was buried around 475 B.C. Aeginetan coins were of central interest in this study. Possible ancient silver mines were explored in the Aegean region in the course of several geologic expeditions, and chemically and isotopically investigated. Some of the silver sources in Greece were traced by combination of the analytical methods and questions of provenance were solved. In addition, processes of silver smelting and refining were studied. Results and implications of this work are summarized in the final section on Conclusions.     

A new pheromone of the silkworm moth Bombyx mori

The female silkmoth Bombyx mori L. emits a second pheromone component bombykal (E-10, Z-12-hexade-cadien-1-al) in addition to the well-known sexual attractant bombykol (E-10, Z-12-hexadecadien-1-ol). Bombykal stimulates its own specialized and highly sensitive olfactory cells of the male moth. Surprisingly, the aldehyde inhibits the release of the male's wing-fluttering response to bombykol.     

Study of heat exposure in the work environment in Jeddah

The present work was conducted to define the magnitude of the problem of heat exposure in Jeddah and the role of both the climatic and the industrial factors on the total heat load. Indoor heat exposure was studied in an industrial complex of 5 plants for cables' manufacturing. Outdoor heat exposure was studied in shaded and unshaded operations in Jeddah Islamic Port (JIP). The heat exposure parameters, including air temperature (Ta), wet bulb temperature (Tw), and globe temperature (Tg), as well as the wet bulb globe temperature (WBGT) heat stress index, the relative humidity and the air velocity, were assessed at representative locations. Results of the study indicated that: