排序方式: 共有37条查询结果,搜索用时 46 毫秒
31.
Tsuji M Vogel CF Koriyama C Akiba S Katoh T Kawamoto T Matsumura F 《Chemosphere》2012,87(11):1228-1234
Background
One of the suggested health outcomes of PCB exposure is childhood asthma.Objectives
This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma.Methods
Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR.Results
Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163 + 164 (P = 0.022), #170 (P = 0.046), #177 (P = 0.022), #178 (P = 0.022) and #180 + 193 (P = 0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects.Conclusion
Serum concentrations of PCB#163 + 164, #170, #177, #178 and #180 + 193 correlate significantly with IL-8 mRNA expressions among asthmatic children. 相似文献32.
Green construction is gaining increasing attention in the global context. However, the construction of sustainable green buildings
and environments involves different tools and systems and diverse perspectives. Therefore, the development of environmental
assessment tools is an important task for managing green housing and green building projects. In this paper, we discuss the
benefits, limitations, and future directions of the assessment framework. There are four characteristics of building environmental
assessment, i.e., comprehensiveness, design guideline, signaling, and communication tools, which afford both benefits and
limitations. We illustrate the role of the assessment framework as a hub promoting integration of diverse knowledge, as a
design guideline encouraging better design and action, as signaling environmentally friendly design and action, and as a communication
tool. On the other hand, there are limitations, such as the use of a mixture of quantitative and qualitative measures, ambiguity
of weighing, lack of financial evaluation, and lack of involvement of diverse disciplines and stakeholders. To develop an
effective assessment framework, the following three factors must be considered: knowledge, power, and implementation. We propose
that knowledge innovation, a credible approach for a salient solution, and collective action represent the future challenges
of the assessment framework. 相似文献
33.
Yuki Haga Motoharu Suzuki Chisato Matsumura Toshihiro Okuno Masahiro Tsurukawa Kazuo Fujimori Narayanan Kannan Roland Weber Takeshi Nakano 《Environmental science and pollution research international》2018,25(17):16446-16454
In this study, we analyzed hydroxylated polychlorinated biphenyls (OH-PCBs) in urine of both PCB transport workers and PCB researchers. A method to monitor OH-PCB in urine was developed. Urine was solid-phase extracted with 0.1% ammonia/ methanol (v/v) and glucuronic acid/sulfate conjugates and then decomposed using β-glucuronidase/arylsulfatase. After alkaline digestion/derivatization, the concentration of OH-PCBs was determined by HRGC/HRMS-SIM. In the first sampling campaign, the worker’s OH-PCB levels increased several fold after the PCB waste transportation work, indicating exposure to PCBs. The concentration of OH-PCBs in PCB transport workers’ urine (0.55~11 μg/g creatinine (Cre)) was higher than in PCB researchers’ urine (< 0.20 μg/g Cre). However, also a slight increase of OH-PCBs was observed in the researchers doing the air sampling at PCB storage area. In the second sampling, after recommended PCB exposure reduction measures had been enacted, the worker’s PCB levels did not increase during handling of PCB equipment. This suggests that applied safety measures improved the situation. Hydroxylated trichlorobiphenyls (OH-TrCBs) were identified as a major homolog of OH-PCBs in urine. Also, hydroxylated tetrachlorobiphenyls (OH-TeCBs) to hydroxylated hexachlorobiphenyls (OH-HxCBs) were detected. For the sum of ten selected major indicators, a strong correlation to total OH-PCBs were found and these can possibly be used as non-invasive biomarkers of PCB exposure in workers managing PCB capacitors and transformer oils. We suggest that monitoring of OH-PCBs in PCB management projects could be considered a non-invasive way to detect exposure. It could also be used as a tool to assess and improve PCB management. This is highly relevant considering the fact that in the next 10 years, approx. 14 million tons of PCB waste need to be managed. Also, the selected populations could be screened to assess whether exposure at work, school, or home has taken place. 相似文献
34.
Nishimura S Maie N Baba M Sudo T Sugiura T Shima E 《Journal of environmental quality》2012,41(3):823-833
Chromophoric dissolved organic matter (CDOM) leached from leaf litter is a major source of humus in mineral soil of forest ecosystems. While their functions and refractoriness depend on the physicochemical structure, there is little information on the quality of CDOM, especially for that leached in the very early stages of litter decomposition when a large amount of dissolved organic matter (DOM) is leached. This study aimed to better understand the variations/changes in the composition of CDOM leached from senescent leaf litter from two tree species during the early stage of decomposition. Leaf litter from a conifer tree (Japanese cedar, D. Don) and a deciduous broad-leaved tree (Konara oak, Thunb.) were incubated in columns using simulated rainfall events periodically for a total of 300 d at 20°C. The quality of CDOM was investigated based on the fluorescence properties by using a combination of excitation-emission matrix fluorescence (EEM) and parallel factor analysis (PARAFAC). In addition, the phenolic composition of DOM was investigated at a molecular level by thermally assisted hydrolysis and methylation-gas chromatography-mass spectrometry (THM-GC-MS) in the presence of tetramethylammonium hydroxide (TMAH). The EEM was statistically decomposed into eight fluorescence components (two tannin/peptide-like peaks, one protein-like peak, and five humic-like peaks). A significant contribution of tannin/peptide-like peaks was observed at the beginning of incubation, but these peaks decreased quickly and humic-like peaks increased within 1 mo of incubation. The composition of humic-like peaks was different between tree species and changed over the incubation period. Since tannin-derived phenolic compounds were detected in the DOM collected after 254 d of incubation on THM-GC-MS, it was suggested that tannins partially changed its structure, forming various humic-like peaks during the early decomposition. 相似文献
35.
Inaba R Furuichi T Komatsu T Tanikawa N Ishii K 《Waste management (New York, N.Y.)》2009,29(1):214-223
In Japan, most farm animal excreta has been stored directly on farmland. Runoff from this storage has often caused water pollution. Biogasification is anticipated as an important technology to manage excreta properly, but complex problems hinder its introduction. Economic aspects of management have been especially difficult for dairy farmers. For this study, structural problems regarding introduction of biogasification into dairy farming were identified. Subsequently, a desirable system of dairy farming including biogasification was suggested, and an evaluation model of the financial balance was constructed. A case study using current financial balances of several systems of dairy farming was evaluated using the constructed model and actual data. The systems were based on several policy alternatives including the suggested system mentioned above. Results show that a farmer can obtain sufficient income from a system featuring centralization of dairy housing and biogasification facilities and coordinated management by over six farmers. 相似文献
36.
37.
Keita Kodama Hiroaki Shiraishi Masatoshi Morita Toshihiro Horiguchi 《Marine Biology》2006,150(1):131-140
To verify the lipofuscin-based age estimation of crustaceans of unknown age from wild populations, we conducted a modal analysis of lipofuscin-concentration histograms in the stomatopod Oratosquilla oratoria seasonally collected from Tokyo Bay, Japan. Confocal microscopy and subsequent image analysis were used to quantify lipofuscin concentrations in the protocerebral bridge cell mass in the brain. Conventional body length frequency analysis failed to detect modes corresponding to ≥1 year old. In contrast, four or five distinct modes were found in the lipofuscin-concentration histograms, in which modes could be readily traced across months, suggesting that each mode represented an independent age group. The lipofuscin accumulation rate fluctuated seasonally: it was high in summer (June–July) and low in winter (December–January). Cross-correlation analysis showed that the highest instantaneous lipofuscin accumulation rate was achieved in early summer before maximum bottom temperatures were reached and when the temperature was increasing most rapidly. Our findings support the usefulness of lipofuscin concentration analysis in age estimation in wild crustacean populations. 相似文献