Über den Einfluß der Thioglykolsäure auf Muskelatmung und Redoxpotential

The Science of Nature -     

Uranium quantification in groundwater and health risk from its ingestion in Haryana,India

Uranium is a naturally occurring radioactive element which may cause toxicological or radiological hazards to the public if present in drinking water. This study reports the quantification of uranium in groundwater of major towns of the district Fatehabad, Haryana, India. Uranium concentrations ranged between 0.3 and 48 μg L^?1. In 22% of the groundwater samples, uranium concentrations were higher than the World Health Organization maximum permissible limit of 30 µg L^?1. The radiological dose for males was found to be in the range of 4.8?×?10^?4–7.1?×?10^?2 mSv y^?1 and for females 3.5?×?10^?4–5.2?×?10^?2 mSv y^?1. The results showed that due to the ingestion of groundwater in the study area, radiological cancer risk is in the range of 9.1?×?10^?7–1.3?×?10^?4, lower than the risk limit. Uranium ingestion from groundwater varied from 0.02 to 3.5 µg kg^?1 day^?1, which is within acceptable limit.     

Synthesis of nanoparticles using microorganisms and their applications: a review

Environmental Chemistry Letters - Nanoparticles synthesis under green conditions has been performed using natural resources to diminish the use of toxic chemicals. For instance, microbial synthesis...     

Environmental issue of exotic catfish culture in Uttar Pradesh

A survey was conducted in Uttar Pradesh to enlist the available exotic fish species in culture. The culture and feeding details of unofficially introduced Clarias gariepinus was collected from 419 ponds existing in rural areas of 23 districts of Uttar Pradesh. The data indicated that 32% ponds were culturing exotic fishes of which 79% cases are of monoculture of exotic African catfish. Feeding analysis of these exotic African catfish revealed that 7% cases subsist on natural pond feed while 29% cases are fed on slaughter house waste. In 32% cases of the exotic magur monoculture, chicken waste was given whereas 11% cases were recorded with fish waste feeding. The possible threats and environmental risks of such unauthorised and indiscreminate culture of exotic magur has been discussed in this paper.     

Transport of metanil yellow in the rat plasma and interaction of its metabolite,p‐aminodiphenylamine with serum proteins

Binding affinity of metanil yellow and its breakdown product p‐aminodiphenylamine to serum proteins has been studied employing chromatographic separation on Sephadex G‐200 and by paper and polyacrylamide gel electrophoresis. Metanil yellow has more affinity towards albumin than to globulins. The complexing is presumably through electrostatic forces. p‐Aminodiphenylamine on the other hand, preferably binds to globulin fractions of serum protein. However, a stable binding with BSA alone was also observed. The binding was quite stable and was accompanied by a shift in absorbance from 430 nm to 500 nm. Aspartic acid moiety of protein was found to be one of the units involved in the binding of p‐ADPA to proteins.     

Nanosystems for drug delivery of coenzyme Q10

Coenzyme Q10 is an antioxidant present in the human body. Coenzyme Q10 has an essential role in various biochemical reactions. The deficiency of coenzyme Q10 in the body leads to disorders including neurological degeneration, ageing and cancer. Clinical trials have tested coenzyme Q10 as a drug or a dietary supplement. However, the major pharmaceutical issue of coenzyme Q10 delivery is its high molecular weight and poor water solubility. This limitation leads to its poor oral bioavailability. Several methods have been designed to overcome the poor water solubility of coenzyme Q10, such as size reduction and ionization. This article presents nanotechnology-based drug delivery systems for coenzyme Q10 with special emphasis on pharmacokinetic perspectives and clinical relevance. Systems include nanoparticles, solid dispersions, liposomes, nanoemulsions, self-emulsifying drug delivery systems, nanostructured lipid carriers, cyclodextrins and nanocapsules.     

Studies on oxidative stress induced nerve conduction deficits in cigarette smokers

An important role of oxidative stress for the development of vascular and neurological complications has encouraged us to undertake a study to assess the oxidative stress induced nerve conduction deficits among cigarette smokers. Eighteen regular male cigarette smokers and twenty nine male non-smokers were diagnosed for clinical neuro-physiological tests viz., motor and sensory nerve conduction velocity (MNCV and SNCV) and redox status. Significant depletion of reduced glutathione (GSH) level (p < 0.05) and significant increase in malondialdehyde (MDA) level (p < 0.01) was found in smokers compared to non-smokers. Motor and sensory nerve conduction velocity showed no significant difference among smokers compared to non-smokers. The present study shows that smoking can induce oxidative stress among smokers but could not exacerbate to nerve conduction deficits.