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Mathematical modeling of competing risks often uses a single risk function for all individuals within a population. In this paper we use several specific examples to argue that such representations remain approximations until account is taken of the existence of genetic variability within and between populations, and the impact of this upon liability to disease. The extent of human genetic variability is also indicated. 相似文献
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This paper seeks to verify the usefulness of selected multivariate statistical techniques for exploring new dose-response relationships between human health and air pollution. We do so by comparing our results with those already established in the literature through hypothesis testing procedures or laboratory work. This use of multivariate techniques is pretheoretical and should be interpreted as suggesting relationships which warrant further investigation with more traditional methodologies. Our results conform very well with those existing in the literature and lend credence to the use of such pretheoretical statistical methods. 相似文献
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William Whipple 《Journal of the American Water Resources Association》1975,11(2):300-305
ABSTRACT: The Delaware Estuary has been intensively studied but the planning for water quality control is very unsatisfactory, including the most recent interagency plan. Earlier planning by the FWPCA and the Delaware River Basin Commission was better; but this planning appears to have been halted and perhaps superseded by the provisions of PL 92–500. The Tocks Island reservoir planned to maintain minimum flows may never be built on account of environmental objections; but the consequences of such a decision are not being faced. Meanwhile recent research indicates that urban runoff will be a major influence possibly adding a load of as much as 500,000 lbs. of BOD in a single storm. Unit costs of treating urban runoff pollution are very high, due to its extreme variability. Artificial aeration or oxygenation may provide a more economical means of improving the dissolved oxygen regimen, as compared to primary treatment of urban runoff, or tertiary treatment of effluents. In any event planning on a regional basis is desirable in the Delaware and elsewhere, and Pl 92–500 may need to be changed to facilitate it. 相似文献