Problems of modern cosmology: how dominant is the vacuum?

It would be hard to find a cosmologist today who does not believe that the vast bulk of the Universe (95% or more) is hidden from our eyes. We review the evidence for this remarkable consensus, and for the latest proposal, that the mysterious dark matter consists of as many as four separate ingredients: baryons, massive neutrinos, new "exotic" dark matter particles, and vacuum energy, also known as the cosmological constant (L\Lambda ). Of these, only baryons fit within standard theoretical physics; the others, if their existence is confirmed, will mean rewriting textbooks. Fresh experimental evidence has recently appeared for and against all four components, so that the subject is in a state of turmoil and excitement. The past 3 years in particular have seen the fourth (vacuum) component come into new prominence, largely at the expense of the third (exotic dark matter). We conclude our review by exploring the possibility that the energy density of the vacuum is in fact so dominant as to leave little room for significant amounts of exotic dark matter.     

Ontogeny of fetal liver glucose-6-phosphatase activity

A reliable and sensitive microassay for the measurement of liver glucose-6-phosphatase is described. Human fetal liver was assayed for glucose-6-phosphatase activity from 7.5 to 24 weeks of gestation and was found to have a mean activity of 2.11 nmol per min per mg of protein. This was approximately 30 per cent of the postnatal controls assayed by the same method, but there was no evidence of a change in activity during the gestational period examined. If fetal liver tissue can be reliably obtained, it may be possible to determine a deficiency of glucose-6-phosphatase in fetuses who are at risk.