Prenatal exclusion of Hurler's disease by leucocyte α-L-iduronidase assay

Hurler's disease was excluded in a fetus at 23 weeks' gestation by demonstrating normal iduronidase activity in fetal leucocytes following failure of amniotic cell culture after amnic-centesis at 16 and 19 weeks' gestation. The diagnosis was confirmed in the neonate.     

机械强化污泥回流式一体化活性污泥法的运行机理研究

活性污泥通过机械搅拌强化污泥内循环回流,提高了污泥的活性,并且使污泥浓度可达到4.5kg/m3,用该机械强化污泥回流式一体化活性污泥法处理小区生活污水,当水力停留时间为3h,溶解氧为2.2mg/L,机械搅拌速度为250r/min时,CODcr、氨氮去除率均可达到83% 以上,出水达到国家污水排放一级标准.该一体化活性污泥法简单易行,运行成本低,投资小,操作维护方便,是生活小区生活污水适宜的处理工艺技术.     

上海市生物废弃物排放管理对策与措施研究

近年来随着上海市生命科学与生物技术的快速发展，其废弃物的环境排放带来了生态与健康的安全隐患。本文在全面调查基础上，归纳分析了上海生物废弃物排放现状，并从意识层面、法规层面、技术层面和管理层面分析目前存在的问题，随后提出了上海生物废弃物排放控制的分类分级、环境安全评估、排放许可证发放、就地与集中处理结合、排污申报登记等基本管理思路和相应的管理组织结构体系。此外，结合当前需要，提出近期实施对策措施。     

DBD降解CF2ClBr过程中自由基与电子能量

利用介质阻挡放电方法对环境污染物CF2ClBr进行了等离子体降解的研究.在前人对该体系的降解产物分析及活性粒子推测的基础上,采用动态反应装置得到了等离子体的发射光谱,进一步确证了等离子体系中出现的CF2、CFCl、F、Cl、Br等主要自由基,并从中推出了等离子态气体可能发生的自由基反应.同时通过发射光谱的分析,近似得到该体系的平均电子能量约为2.42eV.     

Genetic amniocentesis in biamniotic twin pregnancies by a single transabdominal insertion of the needle

We present a technique to aspirate amniotic fluid from both sacs in biamniotic twin pregnancies using a single abdominal insertion with a spinal needle. It was successful in 48 out of 55 cases of biamniotic twin pregnancies referred to our perinatal unit between 1985 and 1994. The single insertion technique was used when the inter-amniotic membrane was clearly evident and two separate free amniotic fluid pools could be reached by the operator with a single puncture. An adequate amount of amniotic fluid was sampled from both sacs to make a cytogenetic diagnosis in all cases. There were four fetuses with trisomy 21 in three twin pregnancies. In two cases, only one twin was affected whilst the co-twin was normal, so that a selective feticide was performed. No miscarriages due to genetic amniocentesis were reported. After 1990, all genetic amniocenteses in biamniotic twin pregnancies (except for one case due to late booking) were performed between 14 and 15 weeks of gestation and with all cases except one, it was possible to sample both twins by a single puncture. We suggest that early amniocentesis (14–15 weeks) by a single abdominal puncture could be a reliable and safe alternative to first-trimester chorionic villus sampling in twin pregnancies.     

海洋环境责任保险

随着海洋环境问题日益尖锐，可能影响海洋环境的作业者，一旦造成海洋环境污染必将面对巨额的责任赔偿与罚款，作业者为降低自己的风险损失，政府为增强其治理及控制污染的能力，作业者不得不购买海洋环境责任保险，本文着重分析了海洋环境责任保险的发展历史，依法强制实行环境责任保险的必要性及海洋环境责任保险的责任范围。     

Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia

Antibiotics have been identified as obesogens contributing to the prevalence of obesity. Moreover, their environmental toxicity shows sex dependence, which might also explain the sex-dependent obesity observed. Yet, the direct evidence for such a connection and the underlying mechanisms remain to be explored. In this study, the effects of tetracycline, which is a representative antibiotic found in both environmental and food samples, on Drosophila melanogaster were studied with consideration of both sex and circadian rhythms (represented by the eclosion rhythm). Results showed that in morning-eclosed adults, tetracycline significantly stimulated the body weight of females (AM females) at 0.1, 1.0, 10.0 and 100.0 µg/L, while tetracycline only stimulated the body weight of males (AM males) at 1.0 µg/L. In the afternoon-eclosed adults, tetracycline significantly stimulated the body weight of females (PM females) at 0.1, 1.0 and 100.0 µg/L, while it showed more significant stimulation in males (PM males) at all concentrations. Notably, the stimulation levels were the greatest in PM males among all the adults. The results showed the clear sex dependence of the obesogenic effects, which was diminished by dysrhythmia. Further biochemical assays and clustering analysis suggested that the sex- and rhythm-dependent obesogenic effects resulted from the bias toward lipogenesis against lipolysis. Moreover, they were closely related to the preference for the energy storage forms of lactate and glucose and also to the presence of excessive insulin, with the involvement of glucolipid metabolism. Such relationships indicated potential bridges between the obesogenic effects of pollutants and other diseases, e.g., cancer and diabetes.