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491.
R. J. Desnick Ph.D. M.D. J. L. Schuette M. S. Golbus L. Jackson H. A. Lubs D. H. Ledbetter M. J. Mahoney E. Pergament J. L. Simpson J. M. Zachary S. E. Fowler G. G. Rhoads F. De La Cruz 《黑龙江环境通报》1992,12(5):357-372
The accuracy of biochemical and molecular prenatal diagnoses using chorionic villi as the fetal source was assessed by seven centres participating in the NICHD collaborative study on the safety and accuracy of chorionic villus sampling (CVS) and amniocentesis. Of 601 pregnancies studied, biochemical methods were used to determine the diagnosis in 283 fetuses at risk for 35 different metabolic disorders. Fifteen different lysosomal storage diseases accounted for 81 per cent of the biochemical prenatal diagnoses performed, with 57 per cent of these pregnancies at risk for Tay-Sachs disease. No errors were made in the biochemical diagnoses that predicted affected or unaffected fetuses. However, the diagnoses of certain disorders (e.g., mucopolysacchariodosis type IH, metachromatic leukodystrophy, and Krabbe disease) occasionally required confirmatory studies in cultured amniocytes because the enzyme results were inconclusive in direct and/or cultured villi or due to the presence of a pseudodeficiency allele. Of these, only the diagnosis of a fetus at risk for Krabbe disease remained inconclusive after special studies to discriminate between mutant and pseudodeficiency alleles. Recombinant DNA techniques were used to predict the diagnosis of 318 fetuses at risk for 16 different disorders in which the defective disease gene could be detected either directly or by linkage analysis to a nearby polymorphic marker. Of these, 32 per cent were for haemoglobinopathies, 25 per cent for cystic fibrosis, 24 per cent for Duchenne or Becker muscular dystrophy, and 7 per cent for haemophilias. Pregnancies at risk for known disorders with specific molecular lesions (e.g., sickle cell disease) were accurately diagnosed in direct and/or cultured villi. Diagnoses requiring analyses with closely linked polymorphic markers were occasionally uninformative or inconclusive. Maternal contamination was not reported in any biochemical or molecular-based diagnosis. These studies document the high accuracy and rapidity of both biochemical and mutation-specific prenatal diagnoses with direct and cultured chorionic villi. 相似文献
492.
Giovanna Moura Calazans Carolina Cristiane Pinto Elizângela Pinheiro da Costa Anna Flávia Perini Sílvia Corrêa Oliveira 《Environmental monitoring and assessment》2018,190(8):491
This study sought to evaluate and propose adjustments to the water quality monitoring network of surface freshwaters in the Paraopeba river basin (Minas Gerais, Brazil), using multivariate statistical methods. A total of 13,560 valid data were analyzed for 19 water quality parameters at 30 monitoring sites, over a period of 5 years (2008–2013). The cluster analysis grouped the monitoring sites in eight groups based on similarities of water quality characteristics. This analysis made it possible to detect the most relevant monitoring stations in the river basin. The principal components analysis associated with non-parametric tests and the analysis of violation of the standards prescribed by law, allowed for identifying the most relevant parameters which must be maintained in the network (thermotolerant coliforms, total manganese, and total phosphorus). The discharge of domestic sewage and industrial wastewater, that from mining activities and diffuse pollution from agriculture and pasture areas are the main sources of pollution responsible for the surface water quality deterioration in this basin. The BP073 monitoring site presents the most degraded water quality in the Paropeba river basin. The monitoring sites BP094 and BP092 are located geographically close and they measure similar water quality, so a possible assessment of the need to maintain only one of the two in the monitoring network is suggested. Therefore, multivariate analyses were efficient to assess the adequacy of the water quality monitoring network of the Paraopeba river basin, and it can be used in other watersheds. 相似文献
493.
Trentin Edicarla Ferreira Paulo Ademar Avelar Ricachenevsky Felipe Klein Morsch Letícia Hindersmann Jacson Tarouco Camila Peligrinotti Nicoloso Fernando Teixeira da Silva Lincon Oliveira Stefanello De Conti Lessandro da Silva Isley Cristiellem Bicalho Marchezan Carina Ceretta Carlos Alberto Brunetto Gustavo 《Environmental science and pollution research international》2022,29(55):82844-82854
Environmental Science and Pollution Research - High soil copper (Cu) concentrations in vineyards can cause phytotoxicity to grapevine rootstocks. In order to mitigate toxicity, the use of grapevine... 相似文献
494.
Gerald Norbert Souza da Silva Márcia Maria Guedes Alcoforado de Moraes 《Regional Environmental Change》2018,18(7):1957-1967
Hydro-economic models can measure the economic effects of different reservoir operating rules, environmental restrictions, maintenance of ecosystems, technical constraints, institutional constraints, land use change, and climate change. To determine the optimal economic water allocation, for its main uses in the sub-middle of the São Francisco River Basin, a hydro-economic optimization model was developed and applied. Demand curves were used rather than fixed requirements for water resources. The results show that operation rules of reservoirs and institutional constraints, such as priorities for human consumption, have high impacts on costs and benefits of the principal economic uses in the study area. Especially, costs of environmental demands, like minimum ecological river flow, have high impacts on the water resource management. Scarcity costs of irrigation users associated with maintaining ecosystems and environmental constraints are particularly significant. The results from this study provide a better understanding of the water trade-offs for future policymaking and efficient water management. Policymaking for the water resources should consider the food-water-energy-environment nexus at a regional scale to minimize environmental and economic cost under water scarcity and land use change. 相似文献
495.
Jesus Silva Rodrigo Nardoto Gabriela Bielefeld Schor Tatiana da Silva Marcia Regina Farias Martinelli Luiz Antônio 《Environment, Development and Sustainability》2022,24(1):1010-1030
Environment, Development and Sustainability - Urbanization has threatened rural communities’ livelihoods worldwide, changing their agro-food systems from locally produced traditional items to... 相似文献
496.
497.
Yasmin Shirin Appelhans Mark Lenz Heloisa Elias Medeiros Bernardo Antonio Perez da Gama Renato Crespo Pereira Martin Wahl 《Marine Biology》2010,157(5):1151-1159
The production of defence metabolites is assumed to be costly in metabolic terms. If this holds true, low-light stress should
reduce the ability of seaweeds to defend themselves chemically against herbivory and fouling. We investigated the effect of
energy limitation on the defensive status of seaweeds by assessing their attractiveness to mesograzers and their activity
against a bivalve macrofouler in comparison with non-stressed conspecifics. The macroalgae Codium decorticatum (Woodw.) M. Howe, Osmundaria obtusiloba (C. Agardh) R. E. Norris, Pterocladiella capillacea (S. G. Gmel.) Santel. and Hommer., Sargassum vulgare C. Agardh and Stypopodium zonale (Lamour.) Papenf. collected at the southeastern Brazilian coast were exposed to six levels of irradiation (between 1 and
180 μmol photons m−2 s−1) for 10–14 days. After this period, algae from all treatment levels were: (a) processed as artificial food and offered to
an amphipod community dominated by Elasmopus brasiliensis Dana and (b) extracted to test for differences in settlement rates of the fouling mussel Perna perna L. on filter paper loaded with the crude extracts. Generally, photosynthesis rates and growth were reduced under low light
conditions. Attractiveness to herbivores and macrofoulers, however, was insensitive to energy limitation. We discuss possible
explanations for the observed absence of a relationship between light availability and algal defence including the change
in nutritional value of the algal tissue, the allocation of resources towards defence instead of growth and the absence of
costs for defence. 相似文献
498.
Débora?Bonfim?Neves?da?Silva Eduardo?Monteiro?Martins Sergio?Machado?CorrêaEmail author 《Environmental monitoring and assessment》2016,188(5):289
The ozone in Rio de Janeiro has been in violation of national air quality standards. Among all of the monitoring stations, the Bangu neighbourhood has the most violations of the national standard of 160 μg m?3 for the years 2012 and 2013. This study evaluated the reactivity of the carbonyls and aromatics in the tropospheric ozone formation processes. The samples were collected between July and October of 2013. Carbonyls were sampled using SiO2 cartridges coated with C18 and impregnated with 2,4-dinitrophenylhydrazine and were analysed by HPLC. Activated carbon cartridges and GC/MS were used to measure the concentration of monoaromatic hydrocarbons. An air quality monitoring station provided the concentrations of the criteria pollutants and the meteorological parameters. Cluster analysis and a Pearson correlation matrix were used to determine the formation of groups and the correlation of the variables. The evaluation of the volatile organic compounds (VOC) reaction with OH radicals and the MIR scale was used to extrapolate the reactivity of VOCs to the ozone formation. The average concentrations obtained were 19.7 and 51.9 μg m?3 for formaldehyde and acetaldehyde, respectively. The mean concentrations obtained for aromatics were 1.5, 6.7, 1.5, 2.6 and 1.6 μg m?3 for benzene, toluene, ethyl benzene, m+p-xylene and o-xylene, respectively. The cluster analysis indicated the presence of three similar groups, with one formed by gaseous criteria pollutants, another formed by the meteorological parameters, ozone and fine particles, and the last group formed by the aromatics. For the two reactivity scales evaluated, acetaldehyde and toluene were the main ozone precursors. 相似文献
499.
Ana Cruz del Álamo María Isabel Pariente Ioanna Vasiliadou Beatriz Padrino Daniel Puyol Raúl Molina Fernando Martínez 《Environmental science and pollution research international》2018,25(35):34884-34892
Conventional wastewater treatment plants (WWTPs) are not able to remove completely some emerging contaminants, such as residual pharmaceutical compounds (PCs) with potential ecotoxicity to water bodies. An advanced bio-oxidation process (ABOP) using white-rot fungi (WRF) has been proposed as alternative biological treatment for degradation of non-biodegradable compounds. A synthetic and real wastewater spiked with 12 PCs at 50 μg L?1 was treated by means of ABOP based on WRF in a rotating biological contactor (RBC) at 1 day of hydraulic retention time (HRT). The ABOP achieved a remarkable biological performance in terms of TOC removal and reduction of N-NH4 + and P-PO4 3? nutrients. Likewise, 5 of the 12 PCs were eliminated with removal efficiencies ranging from 80 to 95%, whereas 6 of 12 PCs were eliminated with removal values ranging from 50 to 70%. The anaerobic digestion of the fungal sludge generated upon the treatment was also evaluated, obtaining a methane yield of 250 mL CH4 gVS ?1. These results evidenced that the proposed ABOP is a promising alternative for the sustainable wastewater treatment of urban effluents, combining advanced oxidation with biological operation for the removal of emerging PCs and energy recovery. 相似文献
500.
Juliana da Silva Ribeiro de Andrade Tulio Machado Fumian José Paulo Gagliardi Leite Matheus Ribeiro de Assis Alexandre Madi Fialho Sergio Mouta Cristiane Mendes Pereira Santiago Marize Pereira Miagostovich 《Food and environmental virology》2018,10(2):212-216
Foodborne transmission gastroenteritis (AGE) outbreak occurred during a celebration lunch in July, 2016, Brazil. All stool samples tested were positive for noroviruses (NoV) and phylogenetic analysis revealed that strains were genetically close to GII.17 Kawasaki_2014. These findings indicated circulation of NoV GII.17 Kawasaki_2014 in the Brazilian population, associated with AGE outbreak. 相似文献