Immunity in children with exposure to environmental lead: II. Effects on humoral immunity

Lead has been found to depress the immune system in animal studies at levels far below those responsible for overt toxicity. Literature studies in animal systems most clearly showed an effect of lead on response to a specific immunogenic stimulus. Data are sparse concerning the effects of lead on the immune system in the human population at greatest risk for exposure-children up to six years of age. This portion of the Phase I study reports concentrations of IgG, IgM, IgA, and IgE, as well as antibody titers to the specific antigenic stimuli provided by the vaccines against diphtheria, tetanus, and Rubella. The study population consisted of a group of 193 children, ages 9 months to 6 years, who participate in the WIC (Women, Infants and Children) and Lead Poisoning Prevention Programs in the urban area of Springfield-Greene County Missouri. Blood lead levels ranged from 1 to 50 g dL^–1. Total Ig levels were determined and the data were analysed. No consistent significant differences were observed among the risk categories in the five age groups examined. A single Ig class in each of three age groups showed apparent significant differences among the various risk categories, but these differences were not correlated with blood lead. An analysis of specific antibody titers to diphtheria, tetanus, and Rubella was performed. Regression analyses of current data in Phase I of this study suggest a detrimental effect of lead on the antibody titres to diphtheria and Rubella.     

Declines in organochlorines in eggs of red-breasted mergansers from Lake Michigan, 1977–1978 versus 1990

From 1977–1978 to 1990, concentrations of polychlorinated biphenyls (PCBs) and most organochlorine pesticides declined in eggs of red-breasted mergansers (Mergus serrator) nesting on islands in northwestern Lake Michigan. Total PCBs decreased 60% (from 21 ppm in 1977–1978 to 8.5 ppm in 1990) and p,p-DDE decreased 66% (from 6.5 to 2.2 ppm). Dieldrin decreased only 16% (from 0.82 to 0.69 ppm). In 1990, 79.1% of incubated eggs hatched, which was not significantly different from the 83.5% that hatched in 1977–1978.The U.S. Government right to retain a non-exclusive, royalty free licence in and to any copyright is acknowledged.     

Interactions between copper and cadmium modify metal organ distribution in mature tilapia, Oreochromis mossambicus

Sexually mature female tilapia were exposed to sublethal concentrations of waterborne Cu and/or Cd over 6 days, and subsequent body concentrations of these metals were determined in several organs. The results show that the distribution of Cu and Cd was metal and organ specific. This is demonstrated, for example, by the observation that in tilapia, Cu exposure did not result in Cu accumulation in the liver, whereas in the intestinal wall, notably high concentrations of Cu and Cd were measured in metal exposed fish. In addition to single metal exposed fish, we also determined Cu and Cd body distribution in Cu?Cd co-exposed fish. The observed interactions in metal accumulation were most pronounced in the organs of fish exposed to low, environmentally realistic, metal concentrations.     

Linear least squares method for time series analysis with an application to a methane time series

A simple method of time series analysis, based upon linear least squares curve fitting, is developed. The method's advantages and disadvantages are discussed, and an example is presented using the Vostok Core methane record.     

中国东南沿海大(中)型浅成中低温热液矿床—斑岩型矿床评价的地质准则、成矿模式及其找矿意义

本文总结中国东南沿海高钾钙碱性—双峰式火山岩带中已勘查大中型矿床成矿环境的共性：矿床所处区域构造的部位、成岩与成矿时代、矿床与岩浆成因类型、火山构造及其基底构造控矿性、矿床与爆发角砾岩、矿床与矿化类型叠加与共生、矿化与蚀变的分带往、矿床定位深度与剥蚀深度。作者认为这八点可作为找寻与评价大（中）型矿床的地质准则。通过火山地质与矿床地质统一的研究提出本区晚中生代以火山为中心地热体系的成矿模式。并就三个方面作类比：①与现代火山地热体系成矿作用类比；②以紫金山高硫型浅成低温热液矿床与世界同类型矿床作比较；③与环太平洋其他火山岩带同类型矿床模式作类比．通过建立本区的模式与类比获得进一步找矿中值得重视的一些思路．     

Ecoprofit-Styria-prepare Thirteen pollution prevention case studies in the Styrian industry

The paper focuses upon the organization of a federal state-funded pollution prevention project in the Styrian industry. The project includes 13 companies from the textile, pulp and paper, machine building, wood working and printed circuit board manufacturing industries, covering most of the sectors and sizes in the Styrian industry. It started in January 1994 and will last for one year. It will demonstrate the possibilities of pollution prevention and the need for further research work. This project will make use of the methods and tools that were refined in the Austrian Prepare project. As a first step, a systematic balance of all the inputs and outputs of a company is made, after which the weak points and inefficiencies of material and energy use are identified and the options for improvements, both economical and ecological, are defined. Consequently, modifications in products and production lead to a situation with less waste and emissions. The preliminary lessons from these projects are presented: as a rule, the utilities (consumption of process materials and water, cleaning, energy, preparatory and finishing steps) are treated as black boxes and usually represent a considerable optimization potential. In these areas especially there is usually a lack of information and coordination as well as a need for a systematic and comprehensive approach. Leadership in the company and creative consultants are needed for starting lasting successful pollution prevention projects.     

Der deutsch-britisch-französische Höchstflußreaktor in Grenoble und sein Forschungsprogramm

The 57-MW high-flux reactor of the Institute Max von Laue-Paul Langevin at Grenoble serves as a central neutron-beam facility for laboratories and research institutes in the three member countries, the United Kingdom, France, and the Federal Republic of Germany. The heavy-water-moderated and -cooled reactor is equipped with hot, thermal, and cold moderators, providing neutrons with high intensity over an unusual wide range of energies (wavelengths) extending from some 0.1 meV (30 Å) up to some 500 meV (0.4 Å). An extensive system of neutron guides with different curvatures permits the transport of neutrons over distances ranging up to 140 m with minimal intensity losses for neutrons in the useful wavelength band. The transmitted beams, in addition, exhibit very low background contamination by fast and epithermal neutrons, and γ-radiation. A large variety of high-resolution neutron spectrometers provide unique opportunities in fields such as nuclear physics, crystallography, solid-state physics, chemistry, metallurgy, and biology.     

Distribution of actinomycetes in oil contaminated ultisols of the Niger Delta (Nigeria)

The distribution of actinomycetes in oil contaminated sandy loam ultisols of the Niger Delta region of Nigeria was studied to aid in understanding the effect of hydrocarbons on indigenous microbial population in tropical soils. The average total counts of actinomycetes in all the oil samples analysed was 103 cfu/g. Higher counts of actinomycetes were observed during the dry season than during the wet season. The counts of hydrocarbonoclastic actinomycetes correlated positively with the total count of actinomycetes.The actinomycetes were generally restricted to the top soil(0-10 cm soil depth) although a seemingly deeper(down to 40 cm soil depth) distribution was noticed in the dry season. The isolates included oil degrading species of Actinoplanes, Norcadia,Streptomyces and Streptosporangium. Their high oil utilization ability indicates their positive potential and role in the bioremediation of oil-spilled soils.     

A biological paleoindicator for early lake acidification: Mallomonadacean (Chrysophyceae) scale abundance in sediments

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