Approaches to studying the genomic architecture of complex birth defects

Every year nearly 6 percent of children worldwide are born with a serious congenital malformation, resulting in death or lifelong disability. In the United States, birth defects remain one of the leading causes of infant mortality. Among the common structural congenital defects are conditions known as neural tube defects (NTDs). These are a class of malformation of the brain and spinal cord where the neural tube fails to close during the neurulation. Although NTDs remain among the most pervasive and debilitating of all human developmental anomalies, there is insufficient understanding of their etiology. Previous studies have proposed that complex birth defects like NTDs are likely omnigenic, involving interconnected gene regulatory networks with associated signals throughout the genome. Advances in technologies have allowed researchers to more critically investigate regulatory gene networks in ever increasing detail, informing our understanding of the genetic basis of NTDs. Employing a systematic analysis of these complex birth defects using massively parallel DNA sequencing with stringent bioinformatic algorithms, it is possible to approach a greater level of understanding of the genomic architecture underlying NTDs. Herein, we present a brief overview of different approaches undertaken in our laboratory to dissect out the genetics of susceptibility to NTDs. This involves the use of mouse models to identify candidate genes, as well as large scale whole genome/whole exome (WGS/WES) studies to interrogate the genomic landscape of NTDs. The goal of this research is to elucidate the gene-environment interactions contributing to NTDs, thus encouraging global research efforts in their prevention.     

Application of Transferable Development Rights in Cultivated Land Protection in China

To analyze current policies on cultivated land protection, this article discusses the application of transferable development rights in cultivated land protection by examining the connotation, operation mechanism, and construction on the market mechanism, benefits driving forces, and expected benefits. The results suggest that economic incentives and fairness have been neglected in previous policies on cultivated land protection. Moreover, the introduction of transferable development rights can not only eliminate the imbalance of interests, but also enhance the incentives for farmers and developers. In addition, it can significantly reduce the fiscal expenditure of the government.     

铁路安全文化建设初探

针对铁路的特点和铁路安全工作的难度以及近两年进行安全基础整顿和建设的经验表明，安全工作仍难以有序可控的不断改进，通过对安全文化的认识和探讨，提出要取得铁路运输安全工作的突破，必须全面加速安全文化建设。加速安全文化建设的前提是加快体制建设，其关键是加快安全机制建设，其保证是加快安全法制建设，其核心是加快干部、工人队伍的安全文化素质提高，其重要方法是加强对全社会的安全知识教育。     

Environmental performance rating and disclosure: China's Green Watch program

In this paper we describe a new incentive-based pollution control program in China, in which the environmental performance of firms is rated from best to worst using five colors--green, blue, yellow, red and black--and the ratings are disseminated to the public through the media. We focus on the first two municipal disclosure programs, which have been implemented at very different levels of economic and institutional development. In both cases, the increases in compliance with pollution regulations have been similar to increases produced by public disclosure programs in Indonesia, the Philippines, and Vietnam. The results suggest that incentives created by public disclosure may significantly reduce pollution in China, even though environmental NGO's play little role and there is no formal channel for public participation in environmental regulation.     

资源开发利用与可持续发展问题探讨

本文在简介资源系统与资源开发概念的基础上,提出了资源开发的原则,并结合我国资源开发的限制因素,提出了开发措施。     

化工企业个人防护用品的检查

为保证化工企业安全生产,必须对个人防护用品严加管理,加强配置和检查。     

对安全意识的探讨

阐明了安全意识的涵义、特征及属性；论述了安全意识的产生、发展及作用；研究了职工在劳动生产中应具有的安全意识和提高其安全意识的基本途径；指出了提高全民安全意识是安全文化建设的最高宗旨。     

试论企业安全管理机制

结合我国安全管理的现状，分析了安全管理机制的性质、功能、内容及建设条件。还讨论了安全与经济效益及安全第一等概念。     

用几种溶样方法对典型土样中Pb、Cr、Ni、Cd、Mn、Cu、Zn的溶出情况比较

本文采用HNO_3、HCl-HNO_3、HNO_3-H_2SO_4-HClO_4,溶洋方法消解土样,用原子吸收法测定题述中的元素,并与HCl-HNO_3-HF-HClO_4全消解方法进行了比较.发现除用HF以外的其它酸溶法Pb、Cr的溶出较少溶出比分别低于55％和67％,主要原因是Pb、Cr包藏在土壤的矿物晶格中。     

催化动力学光度法测定痕量铜（Ⅱ）

研究了在稀硫酸介质中，用α，α‘－联吡啶作活化剂，痕量铜催化高碘酸钾氧化茂红Ｔ的褪色反应及动力学条件，建立了催化动力学光度法测定痕量铜的方法。检测限为０．４１μｇ／ＬＣｕ，线性范围为０－０．８μｇ／２５ｍＬＣｕ。方法操作简单，灵敏度高，准确性好，可用于水质及人发中痕量铜的测定，结果满意。