Age dependence of potentially toxic elements (Sb,Cd, Pb,Ag) in human liver tissue from paediatric subjects

Toxic elements are present at low concentrations in the environment. This work was undertaken to investigate the age dependence of the liver content of selected elements in paediatric populations, as an index of internal exposure. Liver samples were collected at autopsy from 157 subjects, aged < 1 day to 6 years, as part of investigations on a possible role of Sb compounds in sudden infant death syndrome (SIDS). In addition to Sb, the concentrations of Ag, Cd and Pb were also determined by inductively coupled plasma mass spectrometry on the remaining digest. Comparison of 95% confidence intervals of the median concentrations of the four elements suggested that there were no differences between the two categories of cause of death, SIDS or those who had died of an identified disease. Cadmium, lead and antimony median concentrations were lower than corresponding values observed in adult populations. Silver concentrations were significantly higher at birth and decreased with age. Cadmium levels were almost negligible in neonates and infants, but increased in older children. The finding of non-negligible concentrations of both Ag and Pb in neonatal liver provides further direct evidence that these elements cross the human placental barrier. The reported data, by far the largest collection observed in subjects less than 1 year old, are the result of exposure, during pregnancy and in early childhood, to present levels of these elements in the environment. They can serve as a reference to compare post-mortem values from individuals or groups of subjects in this age range when an exposure risk is suspected and to highlight trends in human exposure.     

Macroinvertebrate and fish populations in a restored impounded salt marsh 21 years after the reestablishment of tidal flooding

During the last two decades, the State of Connecticut has restored tidal flow to many impounded salt marshes. One of the first of these and the one most extensively studied is Impoundment One in the Barn Island Wildlife Management Area in Stonington, Connecticut. In 1990, twelve years after the re-establishment of tidal flooding, the density of the marsh snail Melampus bidentatus, the numerically dominant macroinvertebrate of the high marsh, in Impoundment One was about half that in reference marshes below the breached impoundment dike. By 1999 the densities of Melampus above and below the dike were not significantly different, but the shell-free biomass was greater above the dike as a result of the somewhat larger number and size of the snails there. Twenty-one years after the renewal of tidal flooding, three marsh macroinvertebrates (the amphipods Orchestia grillus and Uhlorchestia spartinophila and the mussel Geukensia demissa) were significantly less abundant in the previously impounded marsh than in the reference marshes, whereas another amphipod (Gammarus palustris) was more abundant above the breached dike where conditions appeared to be somewhat wetter. In 1991 the fish assemblage in a mosquito-control ditch in Impoundment One was similar to that in a ditch below the breached dike; however, the common mummichog Fundulus heteroclitus appeared to be less abundant in the restoring marsh. By 1999 the number of mummichogs caught in ditches was significantly greater in Impoundment One than in the reference marsh, but the numbers of mummichogs trapped along the tidal creek were comparable above and below the dike. The results obtained in this study and those of other restoring marshes at Barn Island indicate the full recovery of certain animal populations following the reintroduction of tidal flow to impounded marshes may require up to two or more decades. Furthermore, not only do different species recover at different rates on a single marsh, but the time required for the recovery of a particular species may vary widely from marsh to marsh, often independently of other species.     

Controlling impaired driving through vehicle programs: an overview

The growing recognition of the problem presented by illicit vehicle operation by those whose license has been suspended for driving while intoxicated (DWI) has led to the increasing use of vehicle sanctions. These sanctions include vehicle impoundment and forfeiture, vehicle registration cancellation, and vehicle interlocks as penalties for DWI and driving while suspended (DWS). This article reviews the current information available on the use and effectiveness of vehicle sanctions for reducing offender recidivism. In the United States, 14 states have impoundment laws that are widely used as sanctions for both DWI and DWS, with the length of the impoundment increasing with the number of previous offenses. These laws have been shown to reduce recidivism while the vehicle is in custody and, to a lesser extent, even after the vehicle has been released. Vehicle impoundment is also widely used in Canada and New Zealand. Although a larger number of U.S. states have laws providing for vehicle forfeiture for DWI or DWS, this sanction tends to be limited to multiple offenders and therefore impacts fewer drivers. Cancellation of the vehicle registration and the confiscation of the vehicle plates are increasing in popularity because the vehicle tags are the property of the state, rather than the vehicle owner. Vehicle alcohol interlocks have proven to be an effective method for reducing DWI offender recidivism while they are on the car, but appear to produce only limited post-treatment behavior change. Interlocks are widely used in the United States and Canada and are beginning to be implemented in Europe and Australia. The issues that arise in implementing vehicle sanction programs are discussed and the actions taken by states to deal with them are described.     

Sobriety checkpoints: evidence of effectiveness is strong, but use is limited

There is substantial and consistent evidence from research that highly publicized, highly visible, and frequent sobriety checkpoints in the United States reduce impaired driving fatal crashes by 18% to 24%. Although checkpoints are not conducted in 13 states for legal or policy reasons, there is strong evidence that if conducted appropriately, checkpoints would save lives in the other states. However, a recent survey of checkpoint use has demonstrated that despite the efforts of the U.S. Department of Transportation to encourage checkpoint use through publications, providing funds for equipment, and for officer overtime expenses, only about a dozen of the 37 states that conduct checkpoints do so on a weekly basis. The survey found that lack of local police resources and funding, lack of support by task forces and citizen activists, and the perception that checkpoints are not productive or cost effective are the main reasons for their infrequent use. This article discusses each of these problems and suggests a method for local communities to implement checkpoints without depending on state or federal funds. Low-staffing sobriety checkpoints conducted by as few as three to five officers have been shown to be just as effective as checkpoints conducted by 15 or more officers. A modified sobriety checkpoint program using passive alcohol sensors ("PASpoints") can be implemented by small- to moderate-sized communities in the United States to deter impaired driving. If implemented in a majority of communities, this strategy has a potential level of effectiveness similar to the high level achieved by several Australian states in their random breath-test (RBT) programs. The PASpoint system calls for a small group of three to five officers on traffic patrol duty to converge on a preset site and conduct a mini-checkpoint, returning to their standard patrol duties within two hours. Within this framework, the PASpoint operation would become a standard driving under the influence (DUI) enforcement technique regularly used within the community's jurisdiction. As a standard traffic enforcement activity, the cost would be covered by the normal enforcement budget.